ENSG00000131023


Homo sapiens

Features
Gene ID: ENSG00000131023
  
Biological name :LATS1
  
Synonyms : large tumor suppressor kinase 1 / LATS1 / O95835
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q25.1
Gene start: 149658153
Gene end: 149718256
  
Corresponding Affymetrix probe sets: 1570231_at (Human Genome U133 Plus 2.0 Array)   1570425_s_at (Human Genome U133 Plus 2.0 Array)   219813_at (Human Genome U133 Plus 2.0 Array)   227772_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000444678
Ensembl peptide - ENSP00000441265
Ensembl peptide - ENSP00000444535
Ensembl peptide - ENSP00000253339
Ensembl peptide - ENSP00000403815
Ensembl peptide - ENSP00000437550
NCBI entrez gene - 9113     See in Manteia.
OMIM - 603473
RefSeq - XM_017011482
RefSeq - NM_001270519
RefSeq - NM_004690
RefSeq - XM_017011477
RefSeq - XM_017011478
RefSeq - XM_017011479
RefSeq - XM_017011480
RefSeq - XM_017011481
RefSeq - XM_011536252
RefSeq - XM_017011474
RefSeq - XM_017011475
RefSeq - XM_017011476
RefSeq Peptide - NP_001257448
RefSeq Peptide - NP_004681
swissprot - O95835
swissprot - Q6PJG3
swissprot - H0YG09
Ensembl - ENSG00000131023
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lats1ENSDARG00000003751Danio rerio
 LATS1ENSGALG00000012386Gallus gallus
 Lats1ENSMUSG00000040021Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LATS2 / Q9NRM7 / large tumor suppressor kinase 2ENSG0000015045751
STK38 / Q15208 / serine/threonine kinase 38ENSG0000011207917
Q9Y2H1 / STK38L / serine/threonine kinase 38 likeENSG0000021145517
Q5VT25 / CDC42BPA / CDC42 binding protein kinase alphaENSG0000014377615
ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1ENSG0000006790015
CIT / O14578 / citron rho-interacting serine/threonine kinaseENSG0000012296615
Q9Y5S2 / CDC42BPB / CDC42 binding protein kinase betaENSG0000019875214
ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2ENSG0000013431814
Q6DT37 / CDC42BPG / CDC42 binding protein kinase gammaENSG0000017121914
DMPK / Q09013 / DM1 protein kinaseENSG0000010493612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR009060  UBA-like superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR028741  Serine/threonine-protein kinase LATS1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IBA
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IDA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0000819 sister chromatid segregation IDA
 biological_processGO:0001827 inner cell mass cell fate commitment IEA
 biological_processGO:0001828 inner cell mass cellular morphogenesis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009755 hormone-mediated signaling pathway ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0030833 regulation of actin filament polymerization IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0033146 regulation of intracellular estrogen receptor signaling pathway IMP
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0035329 hippo signaling IEA
 biological_processGO:0043065 positive regulation of apoptotic process IBA
 biological_processGO:0043254 regulation of protein complex assembly IMP
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
 biological_processGO:0046620 regulation of organ growth IBA
 biological_processGO:0051220 cytoplasmic sequestering of protein IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060644 mammary gland epithelial cell differentiation IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:2000058 regulation of ubiquitin-dependent protein catabolic process IMP
 cellular_componentGO:0000922 spindle pole IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030331 estrogen receptor binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114978 MOB1A / Q9H8S9 / MOB kinase activator 1A  / reaction / complex
 ENSG00000137693 YAP1 / P46937 / Yes associated protein 1  / reaction
 ENSG00000113645 WWC1 / Q8IX03 / WW and C2 domain containing 1  / reaction / complex
 ENSG00000173542 MOB1B / Q7L9L4 / MOB kinase activator 1B  / reaction / complex
 ENSG00000131697 NPHP4 / O75161 / nephrocystin 4  / reaction / complex
 ENSG00000018408 WWTR1 / Q9GZV5 / WW domain containing transcription regulator 1  / reaction
 ENSG00000101109 STK4 / Q13043 / serine/threonine kinase 4  / reaction
 ENSG00000104375 STK3 / Q13188 / serine/threonine kinase 3  / reaction






 

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