ENSG00000104375


Homo sapiens

Features
Gene ID: ENSG00000104375
  
Biological name :STK3
  
Synonyms : Q13188 / serine/threonine kinase 3 / STK3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q22.2
Gene start: 98401403
Gene end: 98942827
  
Corresponding Affymetrix probe sets: 204068_at (Human Genome U133 Plus 2.0 Array)   211078_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428295
Ensembl peptide - ENSP00000428167
Ensembl peptide - ENSP00000429369
Ensembl peptide - ENSP00000482260
Ensembl peptide - ENSP00000429744
Ensembl peptide - ENSP00000390500
Ensembl peptide - ENSP00000428014
NCBI entrez gene - 6788     See in Manteia.
OMIM - 605030
RefSeq - XM_017013761
RefSeq - XM_011517248
RefSeq - XM_011517251
RefSeq - XM_011517252
RefSeq - XM_017013756
RefSeq - XM_017013757
RefSeq - XM_017013758
RefSeq - XM_017013759
RefSeq - XM_017013760
RefSeq - NM_001256312
RefSeq - NM_001256313
RefSeq - NM_006281
RefSeq Peptide - NP_001243241
RefSeq Peptide - NP_001243242
RefSeq Peptide - NP_006272
swissprot - Q8NBU1
swissprot - E5RIM6
swissprot - A0A087WZ06
swissprot - E5RFQ9
swissprot - Q13188
Ensembl - ENSG00000104375
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stk3ENSDARG00000011312Danio rerio
 STK3ENSGALG00000032850Gallus gallus
 Stk3ENSMUSG00000022329Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STK4 / Q13043 / serine/threonine kinase 4ENSG0000010110972
STK24 / Q9Y6E0 / serine/threonine kinase 24ENSG0000010257235
STK25 / O00506 / serine/threonine kinase 25ENSG0000011569434
STK26 / Q9P289 / serine/threonine kinase 26ENSG0000013460233


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011524  SARAH domain
 IPR017441  Protein kinase, ATP binding site
 IPR024205  Mst1 SARAH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001841 neural tube formation IEA
 biological_processGO:0003157 endocardium development IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0035329 hippo signaling IEA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0046621 negative regulation of organ growth IEA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IGI
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060215 primitive hemopoiesis IEA
 biological_processGO:0060706 cell differentiation involved in embryonic placenta development IEA
 biological_processGO:0060800 regulation of cell differentiation involved in embryonic placenta development IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0097284 hepatocyte apoptotic process IEA
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity ISS


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction
 ENSG00000151748 SAV1 / Q9H4B6 / salvador family WW domain containing protein 1  / complex
 ENSG00000173542 MOB1B / Q7L9L4 / MOB kinase activator 1B  / reaction
 ENSG00000114978 MOB1A / Q9H8S9 / MOB kinase activator 1A  / reaction
 ENSG00000131023 LATS1 / O95835 / large tumor suppressor kinase 1  / reaction
 ENSG00000150457 LATS2 / Q9NRM7 / large tumor suppressor kinase 2  / reaction
 ENSG00000104375 STK3 / Q13188 / serine/threonine kinase 3  / complex






 

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