MP:0000163 | abnormal cartilage morphology | "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0000165 | abnormal hypertrophic chondrocyte zone | "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0000260 | abnormal angiogenesis | "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0000267 | abnormal cardiac development | "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370] |
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0000291 | enlarged pericardium | "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0 Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0000350 | abnormal cell proliferation | "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0000547 | short limbs | "reduced average length of the extremities" [MGI:CLS, J:61509] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: C57BL/6 * CBA * DBA
Allelic Composition: Stk3tm1.1Rjo/Stk3tm1.1Rjo,Stk4tm1.1Rjo/Stk4tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL
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MP:0000599 | enlarged liver | "larger than average size of the liver" [J:65146] |
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Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: C57BL/6 * CBA * DBA
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MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: C57BL/6 * CBA * DBA
Allelic Composition: Stk3tm1.1Rjo/Stk3tm1.1Rjo,Stk4tm1.1Rjo/Stk4tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL
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MP:0000609 | abnormal liver physiology | "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0000929 | open neural tube | "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0 Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0001176 | abnormal lung development | "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc
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MP:0001533 | abnormal skeleton physiology | "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0001614 | abnormal vasculature | "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0001672 | abnormal embryogenesis/ development | "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0 Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0001701 | incomplete embryo turning | "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571] |
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0001712 | abnormal placental development | "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790] |
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0001713 | reduced trophoblast cell number | "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171] |
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0001716 | abnormal placental labyrinth | "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171] |
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0001722 | pale yolk sac | "bloodless yolk sac" [J:62571] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0 Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0001861 | lung inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc
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MP:0001958 | emphysema | "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc
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MP:0002038 | carcinoma | "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877] |
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Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc
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MP:0002115 | abnormal skeleton extremities morphology | "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0002270 | abnormal alveoli morphology | "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc
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MP:0002584 | small ectoplacental cone | |
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0002836 | abnormal chorion | "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0002941 | increased circulating alanine transaminase level | "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0002942 | decreased circulating alanine transaminase level | "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0002981 | increased liver weight | "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: Stk3tm1.1Rjo/Stk3tm1.1Rjo,Stk4tm1.1Rjo/Stk4tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL
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MP:0003227 | abnormal vascular branching morphogenesis | "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157] |
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0003229 | abnormal vitelline vasculature | "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0 Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0003331 | hepatocellular carcinoma | "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0 Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Stk3tm1.1Jav/Stk3tm1.1Jav,Stk4Gt(AJ0315)Wtsi/Stk4+ Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Stk3tm1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Stk3tm1.1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Stk3tm1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Tg(CAG-cre/Esr1*)5Amc/0 Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Stk3tm1.1Rjo/Stk3tm1.1Rjo,Stk4tm1.1Rjo/Stk4tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL
Allelic Composition: Stk3tm1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * DBA
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MP:0003396 | abnormal embryonic hematopoiesis | "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans
" [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0003638 | abnormal response/metabolism to endogenous compounds | "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0003883 | enlarged stomach | "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Tg(CAG-cre/Esr1*)5Amc/0 Genetic Background: involves: C57BL/6 * CBA
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MP:0003887 | increased hepatocyte apoptosis | "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: C57BL/6 * CBA * DBA
Allelic Composition: Stk3tm1.1Rjo/Stk3tm1.1Rjo,Stk4tm1.1Rjo/Stk4tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL
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MP:0003893 | increased hepatocyte proliferation | "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Stk3tm1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Stk3tm1.1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Tg(CAG-cre/Esr1*)5Amc/0 Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: C57BL/6 * CBA * DBA
Allelic Composition: Stk3tm1.1Rjo/Stk3tm1.1Rjo,Stk4tm1.1Rjo/Stk4tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL
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MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0 Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0004180 | failure of initiation of embryo turning | "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0 Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0004261 | abnormal embryonic neuroepithelium morphology | "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0004265 | abnormal placental transport | "anomaly in the conveyance of metabolic products and nutrients across the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0004686 | decreased length of long bones | "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0005141 | liver hyperplasia | "increased size of liver due to increased hepatocyte cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33827] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0 Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Stk3tm1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Stk3tm1.1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Stk3tm1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129 * C57BL/6
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MP:0005202 | lethargy | "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0 Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0005343 | increased circulating aspartate transaminase level | "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0005632 | decreased circulating aspartate transaminase level | "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0005657 | abnormal neural plate morphology | "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142] |
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0006055 | abnormal vascular endothelial cell morphology | "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0008019 | liver tumor | "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Tg(CAG-cre/Esr1*)5Amc/0 Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Stk3tm1.1Rjo/Stk3tm1.1Rjo,Stk4tm1.1Rjo/Stk4tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL
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MP:0008803 | abnormal placental labyrinth vasculature morphology | "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0008891 | decreased hepatocyte apoptosis | "reduction in the number of hepatocytes undergoing programmed cell death" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0008944 | decreased sensitivity to induced cell death | "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stk3tm1.1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi Genetic Background: involves: 129 * C57BL/6
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MP:0008989 | abnormal liver sinusoid morphology | "any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Stk3tm1.1Rjo/Stk3tm1.1Rjo,Stk4tm1.1Rjo/Stk4tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL
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MP:0009658 | increased placenta apoptosis | "increase in the number of cells of the placenta undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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MP:0009764 | decreased sensitivity to induced morbidity/mortality | "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0010299 | increased mammary gland tumor incidence | "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0 Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0010819 | primary atelectasis | "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc
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MP:0011018 | pulmonary hyaline membrane formation | "abnormal presence of an eosinophilic hyaline (glass-like) material composed of fibrin, proteinaceous exudate and cellular debris, and lining or filling the alveoli, alveolar ducts and bronchioles; hyaline membranes block gas exchange and are usually found at autopsy in individuals that have died of respiratory distress syndrome in the neonatal stages" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc
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MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0 Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0011139 | increased lung endothelial cell proliferation | "greater ability of an endothelial cell in the pulmonary vasculature to undergo expansion by cell division" [MGI:csmith] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc
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MP:0013502 | decreased fibroblast apoptosis | "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith] |
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy Genetic Background: involves: C57BL/6 * CBA
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MP:0013504 | increased embryonic tissue cell apoptosis | "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith] |
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim Genetic Background: Not Specified
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