ENSMUSG00000021067


Mus musculus

Features
Gene ID: ENSMUSG00000021067
  
Biological name :Sav1
  
Synonyms : 1 / Q8VEB2 / Sav1
  
Possible biological names infered from orthology : Q9H4B6 / salvador family WW domain containing protein 1
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C2
Gene start: 69965012
Gene end: 69987002
  
Corresponding Affymetrix probe sets: 10400795 (MoGene1.0st)   1416075_at (Mouse Genome 430 2.0 Array)   1448204_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021467
NCBI entrez gene - 64010     See in Manteia.
MGI - MGI:1927144
RefSeq - NM_022028
RefSeq Peptide - NP_071311
swissprot - Q8VEB2
Ensembl - ENSMUSG00000021067
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sav1ENSDARG00000006196Danio rerio
 SAV1ENSGALG00000012341Gallus gallus
 SAV1ENSG00000151748Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Magi3 / Q9EQJ9 / Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 / Q5TCQ9* / membrane associated guanylate kinase, WW and PDZ domain containing 3*ENSMUSG0000005253927
Magi1 / Q6RHR9 / Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 / Q96QZ7* / membrane associated guanylate kinase, WW and PDZ domain containing 1*ENSMUSG0000004509526
Magi2 / Q9WVQ1 / Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 / Q86UL8* / membrane associated guanylate kinase, WW and PDZ domain containing 2*ENSMUSG0000004000325
Magix / Q4KL35 / PDZ domain-containing protein MAGIX / MAGI family member, X-linked*ENSMUSG000000311479


Protein motifs (from Interpro)
Interpro ID Name
 IPR001202  WW domain
 IPR011524  SARAH domain
 IPR030030  Scaffold protein salvador
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001942 hair follicle development IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030216 keratinocyte differentiation IMP
 biological_processGO:0035329 hippo signaling IGI
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0045600 positive regulation of fat cell differentiation IGI
 biological_processGO:0046620 regulation of organ growth IMP
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0050821 protein stabilization ISO
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0060412 ventricular septum morphogenesis IMP
 biological_processGO:0060487 lung epithelial cell differentiation IMP
 biological_processGO:0060575 intestinal epithelial cell differentiation IMP
 biological_processGO:2000036 regulation of stem cell population maintenance IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000328 increased intestinal cell number "greater than expected number of terminally differentiated cells comprising the majority of the external surface of the intestinal epithelium" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Sav1tm2.1Dlim/Sav1tm2.1Dlim,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Sav1tm2.1Dlim/Sav1tm2.1Dlim,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sav1tm2.1Dlim/Sav1tm2.1Dlim,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001235 disorganized suprabasal layer "anomalous organization of the suprabasal layer of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001329 retina hyperplasia "greater than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Sav1tm1.1Rjo/Sav1tm1.1Rjo,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Sav1tm1Dlim/Sav1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Sav1tm1.1Rjo/Sav1tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL

Allelic Composition: Sav1tm2.1Dlim/Sav1tm2.1Dlim,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0003269 colonic polyps "abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nox4tm1.1Ams/Nox4tm1.1Ams
Genetic Background: B6.129-Nox4tm1.1Ams

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr

Allelic Composition: Rassf1tm1Gpp/Rassf1tm1Gpp,Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Sav1tm1.1Rjo/Sav1tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL

Allelic Composition: Sav1tm2.1Dlim/Sav1tm2.1Dlim,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

Allelic Composition: Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Rassf1tm1Gpp/Rassf1tm1Gpp,Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003789 osteosarcoma "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sav1tm1Dlim/Sav1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Sav1tm1.1Rjo/Sav1tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004839 bile duct hyperplasia "overdevelopment or increased size of the bile ducts, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Rassf1tm1Gpp/Rassf1tm1Gpp,Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nox4tm1.1Ams/Nox4tm1.1Ams
Genetic Background: B6.129-Nox4tm1.1Ams

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Sav1tm1.1Dupa/Sav1tm1.1Dupa,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sav1tm1Dlim/Sav1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Sav1tm1.1Rjo/Sav1tm1.1Rjo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * CD-1 * SJL

Allelic Composition: Sav1tm1.1Rjo/Sav1tm1.1Rjo,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL

Allelic Composition: Sav1tm1Dlim/Sav1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Rassf1tm1Gpp/Rassf1tm1Gpp,Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008109 abnormal small intestinal microvillus morphology "any structural anomaly of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Sav1tm1.1Dupa/Sav1tm1.1Dupa,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

 MP:0008992 abnormal portal lobule morphology "any structural anomaly of the triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sav1tm2.1Dlim/Sav1tm2.1Dlim,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0010040 abnormal oval cell morphology "any structural anomaly of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes" [PMID:16237666]
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Allelic Composition: Sav1tm2.1Dlim/Sav1tm2.1Dlim,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

Allelic Composition: Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Rassf1tm1Gpp/Rassf1tm1Gpp,Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ

 MP:0010042 abnormal oval cell physiology "any functional anomaly of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes" [PMID:16237666]
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Allelic Composition: Sav1tm2.1Dlim/Sav1tm2.1Dlim,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0010054 hepatoblastoma "a malignant neoplasm occurring primarily in the liver and composed of tissue resembling embryonic or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rassf1tm1Gpp/Rassf1tm1Gpp,Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ

 MP:0010264 increased hepatoma incidence "greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sav1tm2.1Dlim/Sav1tm2.1Dlim,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

Allelic Composition: Sav1tm1Dlim/Sav1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010802 abnormal intestinal enteroendocrine cell morphology "any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010945 lung epithelium hyperplasia "overdevelopment or increased size, usually due an increased number of cells in the epithelial layer of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Sav1tm1Dlim/Sav1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022329 Stk3 / Q9JI10 / Mus musculus serine/threonine kinase 3 (Stk3), transcript variant 2, mRNA. / Q13188* / serine/threonine kinase 3*  / complex
 ENSMUSG00000018209 Stk4 / Q9JI11 / serine/threonine kinase 4 / Q13043*  / complex
 ENSMUSG00000021067 1 / Sav1 / Q8VEB2 / Q9H4B6* / salvador family WW domain containing protein 1*  / complex
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

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