ENSDARG00000006196


Danio rerio

Features
Gene ID: ENSDARG00000006196
  
Biological name :sav1
  
Synonyms : salvador family WW domain containing protein 1 / sav1
  
Possible biological names infered from orthology : 1 / Q8VEB2 / Q9H4B6
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 36787077
Gene end: 36798204
  
Corresponding Affymetrix probe sets: Dr.23018.1.A1_at (Zebrafish Array)   NM_001004560_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000025090
NCBI entrez gene - 447821     See in Manteia.
RefSeq - NM_001004560
RefSeq Peptide - NP_001004560
swissprot - Q66HX5
ZFIN ID - ZDB-GENE-040912-28
Ensembl - ENSDARG00000006196
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SAV1ENSGALG00000012341Gallus gallus
 SAV1ENSG00000151748Homo sapiens
 1 ENSMUSG00000021067Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
magi2b / membrane associated guanylate kinase, WW and PDZ domain containing 2b / MAGI2* / Q86UL8* / Q9WVQ1* / membrane associated guanylate kinase, WW and PDZ domain containing 2* / Membran...ENSDARG0000007376923
magi2a / membrane associated guanylate kinase, WW and PDZ domain containing 2a / MAGI2* / Q86UL8* / Q9WVQ1* / membrane associated guanylate kinase, WW and PDZ domain containing 2* / Membran...ENSDARG0000002159023
magi1b / membrane associated guanylate kinase, WW and PDZ domain containing 1b / MAGI1* / Q6RHR9* / Q96QZ7* / membrane associated guanylate kinase, WW and PDZ domain containing 1* / Membran...ENSDARG0000000316923
magi3a / membrane associated guanylate kinase, WW and PDZ domain containing 3a / MAGI3* / Q5TCQ9* / Q9EQJ9* / membrane associated guanylate kinase, WW and PDZ domain containing 3* / Membran...ENSDARG0000010186923
magi3b / membrane associated guanylate kinase, WW and PDZ domain containing 3b / MAGI3* / Q5TCQ9* / membrane associated guanylate kinase, WW and PDZ domain containing 3*ENSDARG0000002597422
magi1a / membrane associated guanylate kinase, WW and PDZ domain containing 1a / MAGI1* / Q96QZ7* / membrane associated guanylate kinase, WW and PDZ domain containing 1*ENSDARG0000007014518
magixa / MAGI family member, X-linked aENSDARG0000002510817
magixb / MAGI family member, X-linked bENSDARG0000007763315


Protein motifs (from Interpro)
Interpro ID Name
 IPR001202  WW domain
 IPR011524  SARAH domain
 IPR030030  Scaffold protein salvador


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0035329 hippo signaling IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0060271 cilium assembly IMP
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct cilium decreased length , abnormal
pronephric duct cilium decreased amount , abnormal
Show

 ZFA:0000151 pronephros pronephros cystic , abnormal
Show

 ZFA:0001117 post-vent region post-vent region increased curvature , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006196 sav1 / salvador family WW domain containing protein 1 / 1 * / Q8VEB2* / Q9H4B6*  / complex
 ENSDARG00000011312 stk3 / Q7ZUQ3 / serine/threonine kinase 3 (STE20 homolog, yeast) / Q13188* / Q9JI10* / serine/threonine kinase 3* / Mus musculus serine/threonine kinase 3 (Stk3), transcript variant 2, mRNA.*  / complex






 

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