ENSMUSG00000063410


Mus musculus

Features
Gene ID: ENSMUSG00000063410
  
Biological name :Stk24
  
Synonyms : Q99KH8 / serine/threonine kinase 24 / Stk24
  
Possible biological names infered from orthology : Q9Y6E0
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: E5
Gene start: 121286343
Gene end: 121380011
  
Corresponding Affymetrix probe sets: 10422396 (MoGene1.0st)   1426247_at (Mouse Genome 430 2.0 Array)   1426248_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078746
NCBI entrez gene - 223255     See in Manteia.
MGI - MGI:2385007
RefSeq - XM_017315988
RefSeq - NM_145465
RefSeq - XM_006518918
RefSeq - XM_011245043
RefSeq Peptide - NP_663440
swissprot - Q3U335
swissprot - Q99KH8
Ensembl - ENSMUSG00000063410
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stk24aENSDARG00000100955Danio rerio
 stk24bENSDARG00000023878Danio rerio
 STK24ENSGALG00000016885Gallus gallus
 STK24ENSG00000102572Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stk25 / Q9Z2W1 / Serine/threonine-protein kinase 25 / O00506* / serine/threonine kinase 25*ENSMUSG0000002627773
Stk26 / Q99JT2 / serine/threonine kinase 26 / Q9P289*ENSMUSG0000003111271
Stk3 / Q9JI10 / Mus musculus serine/threonine kinase 3 (Stk3), transcript variant 2, mRNA. / Q13188* / serine/threonine kinase 3*ENSMUSG0000002232942
Stk4 / Q9JI11 / serine/threonine kinase 4 / Q13043*ENSMUSG0000001820941


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress ISS
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048679 regulation of axon regeneration IEA
 biological_processGO:0048812 neuron projection morphogenesis IBA
 biological_processGO:0097194 execution phase of apoptosis IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008349 MAP kinase kinase kinase kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Apoptotic execution phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Specc1lGt(RRH048)Byg/Specc1l+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Specc1lGt(RRH048)Byg/Specc1l+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Specc1lGt(RRH048)Byg/Specc1l+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Specc1lGt(RRH048)Byg/Specc1l+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025076 Casp7 / P97864 / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11 / P55210* / caspase 7*  / reaction
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

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