ENSMUSG00000025076


Mus musculus

Features
Gene ID: ENSMUSG00000025076
  
Biological name :Casp7
  
Synonyms : Casp7 / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11 / P97864
  
Possible biological names infered from orthology : caspase 7 / P55210
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 56397129
Gene end: 56442344
  
Corresponding Affymetrix probe sets: 10464128 (MoGene1.0st)   1426062_a_at (Mouse Genome 430 2.0 Array)   1448659_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026062
NCBI entrez gene - 12369     See in Manteia.
MGI - MGI:109383
RefSeq - XM_006526616
RefSeq - NM_007611
RefSeq Peptide - NP_031637
swissprot - P97864
swissprot - Q4FJQ4
Ensembl - ENSMUSG00000025076
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casp7ENSDARG00000091836Danio rerio
 CASP7ENSGALG00000008933Gallus gallus
 CASP7ENSG00000165806Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*ENSMUSG0000003162848
Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*ENSMUSG0000002602935
Casp9 / Q8C3Q9 / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA. / P55211* / caspase 9*ENSMUSG0000002891433
Casp6 / O08738 / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11 / P55212* / caspase 6*ENSMUSG0000002799732
Casp2 / P29594 / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12 / P42575* / caspase 2*ENSMUSG0000002986326
Casp14 / O89094 / Caspase-14 Caspase-14 subunit p17, mature form Caspase-14 subunit p10, mature form Caspase-14 subunit p20, intermediate form Caspase-14 subunit p8, intermediate form / P31...ENSMUSG0000000535523
Casp16-ps / caspase 16, apoptosis-related cysteine peptidase, pseudogeneENSMUSG0000006788214


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis RCA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0007507 heart development IGI
 biological_processGO:0007568 aging IEA
 biological_processGO:0009411 response to UV IGI
 biological_processGO:0016485 protein processing IDA
 biological_processGO:0051402 neuron apoptotic process IDA
 biological_processGO:0072734 cellular response to staurosporine ISO
 biological_processGO:0097194 execution phase of apoptosis IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IDA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity RCA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IDA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
Caspase-mediated cleavage of cytoskeletal proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7+
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7+
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7+
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7tm1Flv
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7+
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7tm1Flv
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7tm1Flv
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7tm1Flv
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

 MP:0013502 decreased fibroblast apoptosis "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7+
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp7tm1Flv/Casp7tm1Flv
Genetic Background: B6.129S-Casp3tm1Flv Casp7tm1Flv

Allelic Composition: Casp7tm1Flv/Casp7tm1Flv
Genetic Background: B6.129S6-Casp7tm1Flv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030498 Gas2 / P11862 / Mus musculus growth arrest specific 2 (Gas2), transcript variant 2, mRNA. / O43903* / growth arrest specific 2*  / reaction
 ENSMUSG00000029433 Diablo / Q9JIQ3 / Diablo homolog, mitochondrial / Q9NR28* / diablo IAP-binding mitochondrial protein*  / complex / reaction
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / reaction
 ENSMUSG00000063410 Stk24 / Q99KH8 / serine/threonine kinase 24 / Q9Y6E0*  / reaction
 ENSMUSG00000026728 Vim / P20152 / vimentin / P08670*  / reaction
 ENSMUSG00000025076 Casp7 / P97864 / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11 / P55210* / caspase 7*  / complex
 ENSMUSG00000042489 Clspn / Q80YR7 / Claspin / Q9HAW4*  / reaction
 ENSMUSG00000025860 Xiap / Q60989 / X-linked inhibitor of apoptosis / BIRC8* / P98170* / Q96P09* / baculoviral IAP repeat containing 8*  / complex






 

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