Manteia

ENSMUSG00000029433

Mus musculus

Features

Gene ID:	ENSMUSG00000029433

Biological name :	Diablo

Synonyms :	Diablo / Diablo homolog, mitochondrial / Q9JIQ3

Possible biological names infered from orthology :	diablo IAP-binding mitochondrial protein / Q9NR28

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	F
Gene start:	123509765
Gene end:	123524176

Corresponding Affymetrix probe sets:	10533633 (MoGene1.0st) 1417683_at (Mouse Genome 430 2.0 Array) 1425768_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000115045 Ensembl peptide - ENSMUSP00000143673 Ensembl peptide - ENSMUSP00000143617 Ensembl peptide - ENSMUSP00000143485 Ensembl peptide - ENSMUSP00000031385 Ensembl peptide - ENSMUSP00000107213 Ensembl peptide - ENSMUSP00000107214 NCBI entrez gene - 66593 See in Manteia. MGI - MGI:1913843 RefSeq - NM_023232 RefSeq Peptide - NP_075721 swissprot - Q8R1D8 swissprot - D3Z3K5 swissprot - Q9JIQ3 swissprot - D3Z2Q3 swissprot - A0A0G2JGS0 Ensembl - ENSMUSG00000029433

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR009062	Smac/DIABLO-like superfamily
IPR015142	Smac/DIABLO protein

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IEA
biological_process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	IDA
biological_process	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	IDA
biological_process	GO:0043065	positive regulation of apoptotic process	TAS
biological_process	GO:0051402	neuron apoptotic process	IDA
biological_process	GO:0097193	intrinsic apoptotic signaling pathway	TAS
cellular_component	GO:0005737	cytoplasm	IDA
cellular_component	GO:0005739	mitochondrion	IEA
cellular_component	GO:0005758	mitochondrial intermembrane space	ISO
cellular_component	GO:0009898	cytoplasmic side of plasma membrane	IDA
cellular_component	GO:0035631	CD40 receptor complex	IDA

Pathways (from Reactome)

Pathway description

Release of apoptotic factors from the mitochondria

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Htra2^tm1Jdo/Htra2^tm1Jdo,Diablo^tm1Mak/Diablo^tm1Mak Genetic Background: involves: 129P/Ola * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Htra2^tm1Jdo/Htra2^tm1Jdo,Diablo^tm1Mak/Diablo^tm1Mak Genetic Background: involves: 129P/Ola * C57BL/6
MP:0001388	abnormal stationary movement	"altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Htra2^tm1Jdo/Htra2^tm1Jdo,Diablo^tm1Mak/Diablo^tm1Mak Genetic Background: involves: 129P/Ola * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd9^tm1Mek/Cd9^tm1Mek Genetic Background: involves: 129/Sv * C57BL/6
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Htra2^tm1Jdo/Htra2^tm1Jdo,Diablo^tm1Mak/Diablo^tm1Mak Genetic Background: involves: 129P/Ola * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000025076	Casp7 / P97864 / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11 / P55210* / caspase 7*	/ complex / reaction
ENSMUSG00000025860	Xiap / Q60989 / X-linked inhibitor of apoptosis / BIRC8* / P98170* / Q96P09* / baculoviral IAP repeat containing 8*	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr