ENSMUSG00000025860


Mus musculus

Features
Gene ID: ENSMUSG00000025860
  
Biological name :Xiap
  
Synonyms : Q60989 / Xiap / X-linked inhibitor of apoptosis
  
Possible biological names infered from orthology : baculoviral IAP repeat containing 8 / BIRC8 / P98170 / Q96P09
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A4
Gene start: 42059679
Gene end: 42109656
  
Corresponding Affymetrix probe sets: 10599369 (MoGene1.0st)   1421394_a_at (Mouse Genome 430 2.0 Array)   1426636_a_at (Mouse Genome 430 2.0 Array)   1437533_at (Mouse Genome 430 2.0 Array)   1450231_a_at (Mouse Genome 430 2.0 Array)   1450232_at (Mouse Genome 430 2.0 Array)   1453385_at (Mouse Genome 430 2.0 Array)   1456088_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121482
Ensembl peptide - ENSMUSP00000110747
Ensembl peptide - ENSMUSP00000153528
Ensembl peptide - ENSMUSP00000026978
Ensembl peptide - ENSMUSP00000061074
Ensembl peptide - ENSMUSP00000110746
NCBI entrez gene - 11798     See in Manteia.
MGI - MGI:107572
RefSeq - XM_017318362
RefSeq - XM_006541427
RefSeq - XM_011250976
RefSeq - XM_011250977
RefSeq - XM_017318359
RefSeq - XM_017318360
RefSeq - XM_017318361
RefSeq - NM_001301639
RefSeq - NM_001301641
RefSeq - NM_009688
RefSeq - XM_006541425
RefSeq Peptide - NP_033818
RefSeq Peptide - NP_001288568
RefSeq Peptide - NP_001288570
swissprot - A2BGY5
swissprot - Q60989
swissprot - A0A286YE63
Ensembl - ENSMUSG00000025860
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xiapENSDARG00000016143Danio rerio
 XIAPENSGALG00000008491Gallus gallus
 BIRC8ENSG00000163098Homo sapiens
 XIAPENSG00000101966Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*ENSMUSG0000005736737
Birc3 / baculoviral IAP repeat containing 3 / Q13489*ENSMUSG0000003200036
Naip6 / Q9JIB6 / NLR family, apoptosis inhibitory protein 6 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000007894225
Naip5 / NLR family, apoptosis inhibitory protein 5 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000007120325
Naip2 / Q9QUK4 / NLR family, apoptosis inhibitory protein 2 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000007894524
Naip1 / Q9QWK5 / NLR family, apoptosis inhibitory protein 1 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000002164024
Birc7 / A2AWP0 / Baculoviral IAP repeat-containing protein 7 Baculoviral IAP repeat-containing protein 7 30 kDa subunit / Q96CA5* / baculoviral IAP repeat containing 7*ENSMUSG0000003884018
Nlrc4 / Q3UP24 / NLR family CARD domain-containing protein 4 / Q9NPP4* / NLR family CARD domain containing 4*ENSMUSG000000391939


Protein motifs (from Interpro)
Interpro ID Name
 IPR001370  BIR repeat
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0051402 neuron apoptotic process IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IBA
 biological_processGO:1902530 positive regulation of protein linear polyubiquitination ISO
 biological_processGO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity ISO


Pathways (from Reactome)
Pathway description
SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
Deactivation of the beta-catenin transactivating complex
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Regulation of necroptotic cell death
Regulation of PTEN localization
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ern1tm1Dron/Ern1tm1Dron
Genetic Background: involves: 129S6/SvEvTac

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Xiaptm1Vdr/Xiaptm1Vdr
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Xiaptm1Vdr/Xiaptm1Vdr
Genetic Background: involves: 129S1/Sv

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk3tm1Vmd/Ripk3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Xiaptm1Vdr/Xiaptm1Vdr
Genetic Background: involves: 129S1/Sv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Birc3tm1.1Rbr/Birc3tm1.1Rbr,Xiaptm1Vdr/Xiaptm1Vdr
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Xiaptm1Vdr/Xiaptm1Vdr
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Xiaptm1Vdr/Xiaptm1Vdr
Genetic Background: involves: 129S1/Sv

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ern1tm1Dron/Ern1tm1Dron
Genetic Background: involves: 129S6/SvEvTac

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Xiaptm1Vdr/Xiaptm1Vdr
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Xiaptm1Vdr/Xiaptm1Vdr
Genetic Background: involves: 129S1/Sv

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Xiaptm1Vdr/Xiaptm1Vdr
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Xiaptm1Vdr/Xiaptm1Vdr
Genetic Background: involves: 129S1/Sv

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Xiaptm1Vdr/Xiaptm1Vdr
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Xiaptm1Vdr/Xiaptm1Vdr
Genetic Background: involves: 129S1/Sv

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ern1tm1Dron/Ern1tm1Dron
Genetic Background: involves: 129S6/SvEvTac

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ern1tm1Dron/Ern1tm1Dron
Genetic Background: involves: 129S6/SvEvTac

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk3tm1Vmd/Ripk3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Xiaptm1Vdr/Xiaptm1Vdr
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Xiaptm1Vdr/Xiaptm1Vdr
Genetic Background: involves: 129S1/Sv

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk3tm1Vmd/Ripk3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0013716 hypolactation "partial failure, or reduced ability to produce or secrete milk from the mammary gland" [MGI:Anna]
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Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029433 Diablo / Q9JIQ3 / Diablo homolog, mitochondrial / Q9NR28* / diablo IAP-binding mitochondrial protein*  / complex / reaction
 ENSMUSG00000025076 Casp7 / P97864 / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11 / P55210* / caspase 7*  / complex
 ENSMUSG00000024642 Tle4 / Q62441 / Transducin-like enhancer protein 4 / Q04727* / transducin like enhancer of split 4*  / complex / reaction
 ENSMUSG00000032280 Tle3 / Q08122 / transducin-like enhancer of split 3 / Q04726*  / complex / reaction
 ENSMUSG00000008305 Tle1 / Q62440 / Transducin-like enhancer protein 1 / Q04724* / transducin like enhancer of split 1*  / reaction / complex
 ENSMUSG00000034771 Tle2 / Q9WVB2 / transducin-like enhancer of split 2 / Q04725*  / complex / reaction






 

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