ENSMUSG00000008305


Mus musculus

Features
Gene ID: ENSMUSG00000008305
  
Biological name :Tle1
  
Synonyms : Q62440 / Tle1 / Transducin-like enhancer protein 1
  
Possible biological names infered from orthology : Q04724 / transducin like enhancer of split 1
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C3
Gene start: 72117142
Gene end: 72200919
  
Corresponding Affymetrix probe sets: 10513884 (MoGene1.0st)   1422751_at (Mouse Genome 430 2.0 Array)   1434033_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118683
Ensembl peptide - ENSMUSP00000102960
Ensembl peptide - ENSMUSP00000118513
Ensembl peptide - ENSMUSP00000030095
Ensembl peptide - ENSMUSP00000072481
Ensembl peptide - ENSMUSP00000073839
Ensembl peptide - ENSMUSP00000099912
NCBI entrez gene - 21885     See in Manteia.
MGI - MGI:104636
RefSeq - XM_017320112
RefSeq - NM_001285529
RefSeq - NM_001285530
RefSeq - NM_001285531
RefSeq - NM_001285532
RefSeq - NM_011599
RefSeq - XM_011249981
RefSeq - XM_011249982
RefSeq - XM_011249985
RefSeq - XM_011249986
RefSeq - XM_017320104
RefSeq - XM_017320105
RefSeq - XM_017320106
RefSeq - XM_017320107
RefSeq - XM_017320108
RefSeq - XM_017320109
RefSeq - XM_017320110
RefSeq - XM_017320111
RefSeq - XM_006537758
RefSeq - XM_006537759
RefSeq - XM_006537760
RefSeq - XM_006537761
RefSeq - XM_006537766
RefSeq - XM_011249978
RefSeq - XM_011249979
RefSeq - XM_011249980
RefSeq Peptide - NP_001272458
RefSeq Peptide - NP_001272459
RefSeq Peptide - NP_001272460
RefSeq Peptide - NP_001272461
RefSeq Peptide - NP_035729
swissprot - Q5SQA2
swissprot - Q5SQA3
swissprot - Q5SQA4
swissprot - Q5SQA5
swissprot - Q5SQA7
swissprot - Q62440
swissprot - E9Q2Q6
Ensembl - ENSMUSG00000008305
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLE1ENSGALG00000012575Gallus gallus
 TLE1ENSG00000196781Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tle4 / Q62441 / Transducin-like enhancer protein 4 / Q04727* / transducin like enhancer of split 4*ENSMUSG0000002464286
Tle3 / Q08122 / transducin-like enhancer of split 3 / Q04726*ENSMUSG0000003228080
Tle2 / Q9WVB2 / transducin-like enhancer of split 2 / Q04725*ENSMUSG0000003477165
Gm21964 / transducin like enhancer of split family member 7 / TLE7*ENSMUSG0000009594118
Tle6 / Q9WVB3 / transducin-like enhancer of split 6 / Q9H808*ENSMUSG0000003475817
Aes / P63002 / Amino-terminal enhancer of split / Q08117*ENSMUSG0000005445217


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR005617  Groucho/TLE, N-terminal Q-rich domain
 IPR009146  Groucho/transducin-like enhancer
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IGI
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:2000811 negative regulation of anoikis ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:1990907 beta-catenin-TCF complex IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025860 Xiap / Q60989 / X-linked inhibitor of apoptosis / BIRC8* / P98170* / Q96P09* / baculoviral IAP repeat containing 8*  / reaction / complex
 ENSMUSG00000027985 Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*  / reaction / complex
 ENSMUSG00000008305 Tle1 / Q62440 / Transducin-like enhancer protein 1 / Q04724* / transducin like enhancer of split 1*  / complex / reaction
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction
 ENSMUSG00000024985 Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*  / complex / reaction
 ENSMUSG00000032280 Tle3 / Q08122 / transducin-like enhancer of split 3 / Q04726*  / reaction
 ENSMUSG00000024642 Tle4 / Q62441 / Transducin-like enhancer protein 4 / Q04727* / transducin like enhancer of split 4*  / reaction
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / complex
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / complex
 ENSMUSG00000034771 Tle2 / Q9WVB2 / transducin-like enhancer of split 2 / Q04725*  / reaction






 

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