ENSMUSG00000032280


Mus musculus

Features
Gene ID: ENSMUSG00000032280
  
Biological name :Tle3
  
Synonyms : Q08122 / Tle3 / transducin-like enhancer of split 3
  
Possible biological names infered from orthology : Q04726
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 61372366
Gene end: 61418497
  
Corresponding Affymetrix probe sets: 10586039 (MoGene1.0st)   1419654_at (Mouse Genome 430 2.0 Array)   1419655_at (Mouse Genome 430 2.0 Array)   1449554_at (Mouse Genome 430 2.0 Array)   1458512_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124173
Ensembl peptide - ENSMUSP00000136010
Ensembl peptide - ENSMUSP00000125537
Ensembl peptide - ENSMUSP00000125049
Ensembl peptide - ENSMUSP00000125032
Ensembl peptide - ENSMUSP00000125011
Ensembl peptide - ENSMUSP00000124977
Ensembl peptide - ENSMUSP00000124557
Ensembl peptide - ENSMUSP00000124432
Ensembl peptide - ENSMUSP00000034820
Ensembl peptide - ENSMUSP00000123723
Ensembl peptide - ENSMUSP00000124055
Ensembl peptide - ENSMUSP00000124131
Ensembl peptide - ENSMUSP00000124150
Ensembl peptide - ENSMUSP00000124158
NCBI entrez gene - 21887     See in Manteia.
MGI - MGI:104634
RefSeq - XM_017313279
RefSeq - XM_017313278
RefSeq - XM_017313277
RefSeq - XM_006511031
RefSeq - XM_006511030
RefSeq - XM_006511029
RefSeq - XM_006511028
RefSeq - XM_006511027
RefSeq - XM_006511026
RefSeq - XM_006511025
RefSeq - NM_001083927
RefSeq - NM_009389
RefSeq - NM_001083928
RefSeq Peptide - NP_001077396
RefSeq Peptide - NP_001077397
RefSeq Peptide - NP_033415
swissprot - E0CYM5
swissprot - Q08122
swissprot - Q3TY99
swissprot - J3KMT7
swissprot - F8WIE2
swissprot - F6TS96
swissprot - E0CXS2
swissprot - E0CXS9
swissprot - E0CXU1
swissprot - E0CY14
swissprot - E0CY76
swissprot - E0CZB4
swissprot - E0CYI6
Ensembl - ENSMUSG00000032280
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tle3aENSDARG00000002787Danio rerio
 tle3bENSDARG00000069006Danio rerio
 TLE3ENSGALG00000008120Gallus gallus
 TLE3ENSG00000140332Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tle4 / Q62441 / Transducin-like enhancer protein 4 / Q04727* / transducin like enhancer of split 4*ENSMUSG0000002464282
Tle1 / Q62440 / Transducin-like enhancer protein 1 / Q04724* / transducin like enhancer of split 1*ENSMUSG0000000830579
Tle2 / Q9WVB2 / transducin-like enhancer of split 2 / Q04725*ENSMUSG0000003477164
Tle6 / Q9WVB3 / transducin-like enhancer of split 6 / Q9H808*ENSMUSG0000003475818
Gm21964 / transducin like enhancer of split family member 7 / TLE7*ENSMUSG0000009594117
Aes / P63002 / Amino-terminal enhancer of split / Q08117*ENSMUSG0000005445216


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR005617  Groucho/TLE, N-terminal Q-rich domain
 IPR009146  Groucho/transducin-like enhancer
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030154 cell differentiation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:1990907 beta-catenin-TCF complex IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0001711 abnormal placenta 
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005216 abnormal pancreatic alpha cell morphology "malformation of the cells of the pancreas that secrete glucagon" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0005336 abnormal inguinal fat pad "malformed or aberrant size of the encapsulated adipose tissue found in the groin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0009116 abnormal brown fat cell morphology "any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]
Show

Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0009175 abnormal pancreatic beta cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete insulin, and/or accumulation of pancreatic beta cell precursors" [MESH:A03.734.414.131]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0009179 abnormal pancreatic alpha cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete glucagon, and/or accumulation of pancreatic alpha cell precursors" [MESH:A03.734.414.065]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0009183 abnormal pancreatic delta cell differentation "atypical production of or inability to produce the cells found in the pancreas that secrete somatostatin, and/or accumulation of pancreatic delta cell precursors" [MESH:A03.556.875.875.440.854]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0009188 abnormal PP cell differentiation "atypical production of or inability to produce the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas, and/or accumulation of PP cell precursors" [CL:0000696, MESH:A03.734.414.587]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0009189 abnormal pancreatic epsilon cell morphology "any structural anomaly of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin" [PMID:14970313]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0009193 abnormal pancreatic epsilon cell differentiation "atypical production of or inability to produce the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin, and/or accumulation of pancreatic epsilon cell precursors" [PMID:14970313]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0011016 increased core body temperature "increased degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0011167 abnormal adipose tissue development "anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0020523 decreased susceptibility to induced hypothermia "smaller than expected drop in body temperature in response to treatment (cold-exposure, dietary restriction, ethanol treatment, etc..) designed to induce hypothermia" [MGI:mperry, PMID:24531262]
Show

Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025860 Xiap / Q60989 / X-linked inhibitor of apoptosis / BIRC8* / P98170* / Q96P09* / baculoviral IAP repeat containing 8*  / reaction / complex
 ENSMUSG00000024985 Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*  / complex / reaction
 ENSMUSG00000008305 Tle1 / Q62440 / Transducin-like enhancer protein 1 / Q04724* / transducin like enhancer of split 1*  / reaction
 ENSMUSG00000027985 Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*  / reaction / complex
 ENSMUSG00000032280 Tle3 / Q08122 / transducin-like enhancer of split 3 / Q04726*  / complex / reaction
 ENSMUSG00000034771 Tle2 / Q9WVB2 / transducin-like enhancer of split 2 / Q04725*  / reaction
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction
 ENSMUSG00000024642 Tle4 / Q62441 / Transducin-like enhancer protein 4 / Q04727* / transducin like enhancer of split 4*  / reaction
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / complex
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / complex






 

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