ENSDARG00000069006


Danio rerio

Features
Gene ID: ENSDARG00000069006
  
Biological name :tle3b
  
Synonyms : O13168 / tle3b / transducin-like enhancer of split 3b
  
Possible biological names infered from orthology : Q04726 / Q08122 / TLE3 / transducin like enhancer of split 3
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 33644434
Gene end: 33684632
  
Corresponding Affymetrix probe sets: Dr.23459.1.A1_at (Zebrafish Array)   Dr.23459.1.S1_s_at (Zebrafish Array)   Dr.6493.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000143498
Ensembl peptide - ENSDARP00000149962
Ensembl peptide - ENSDARP00000109120
Ensembl peptide - ENSDARP00000142910
NCBI entrez gene - 100007463     See in Manteia.
RefSeq - XM_005168834
RefSeq Peptide - NP_571855
swissprot - A0A1D5NSU2
swissprot - O13168
ZFIN ID - ZDB-GENE-990415-85
Ensembl - ENSDARG00000069006
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLE3ENSGALG00000008120Gallus gallus
 TLE3ENSG00000140332Homo sapiens
 Tle3ENSMUSG00000032280Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tle3a / transducin-like enhancer of split 3a / TLE3* / Q08122* / Q04726* / transducin like enhancer of split 3*ENSDARG0000000278794
tle2a / transducin like enhancer of split 2aENSDARG0000004248472
tle2b / transducin like enhancer of split 2bENSDARG0000000876771
tle2c / transducin like enhancer of split 2cENSDARG0000006783220
chico / AES* / Q08117* / amino-terminal enhancer of split*ENSDARG0000001958816
aes / amino-terminal enhancer of split / P63002* / Q08117*ENSDARG0000002180516


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR005617  Groucho/TLE, N-terminal Q-rich domain
 IPR009146  Groucho/transducin-like enhancer
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030099 myeloid cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood blood cell absent , abnormal
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 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm blood cell present , abnormal
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 ZFA:0000588 statoacoustic (VIII) ganglion statoacoustic (VIII) ganglion neuron decreased amount , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000031894 lef1 / lymphoid enhancer-binding factor 1 / P27782* / Q9UJU2*  / complex / reaction
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / reaction
 ENSDARG00000069006 tle3b / O13168 / transducin-like enhancer of split 3b / TLE3* / Q08122* / Q04726* / transducin like enhancer of split 3*  / complex / reaction
 ENSDARG00000015427 hdac1 / histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / complex






 

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