ENSG00000140332


Homo sapiens

Features
Gene ID: ENSG00000140332
  
Biological name :TLE3
  
Synonyms : Q04726 / TLE3 / transducin like enhancer of split 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q23
Gene start: 70047790
Gene end: 70098176
  
Corresponding Affymetrix probe sets: 206472_s_at (Human Genome U133 Plus 2.0 Array)   212769_at (Human Genome U133 Plus 2.0 Array)   212770_at (Human Genome U133 Plus 2.0 Array)   228340_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457641
Ensembl peptide - ENSP00000456178
Ensembl peptide - ENSP00000485965
Ensembl peptide - ENSP00000319233
Ensembl peptide - ENSP00000394717
Ensembl peptide - ENSP00000415057
Ensembl peptide - ENSP00000442594
Ensembl peptide - ENSP00000452803
Ensembl peptide - ENSP00000452809
Ensembl peptide - ENSP00000452871
Ensembl peptide - ENSP00000452881
Ensembl peptide - ENSP00000452933
Ensembl peptide - ENSP00000453081
Ensembl peptide - ENSP00000453083
Ensembl peptide - ENSP00000453107
Ensembl peptide - ENSP00000453219
Ensembl peptide - ENSP00000453373
Ensembl peptide - ENSP00000453435
Ensembl peptide - ENSP00000453760
Ensembl peptide - ENSP00000454029
Ensembl peptide - ENSP00000454141
NCBI entrez gene - 7090     See in Manteia.
OMIM - 600190
RefSeq - XM_017022532
RefSeq - NM_001105192
RefSeq - NM_001282979
RefSeq - NM_001282980
RefSeq - NM_001282981
RefSeq - NM_001282982
RefSeq - NM_005078
RefSeq - NM_020908
RefSeq - XM_005254622
RefSeq - XM_005254623
RefSeq - XM_005254625
RefSeq - XM_005254628
RefSeq - XM_005254633
RefSeq - XM_006720665
RefSeq - XM_011521976
RefSeq - XM_011521977
RefSeq - XM_011521978
RefSeq - XM_011521979
RefSeq - XM_011521980
RefSeq - XM_011521981
RefSeq - XM_011521982
RefSeq - XM_011521983
RefSeq Peptide - NP_065959
RefSeq Peptide - NP_001269910
RefSeq Peptide - NP_001269911
RefSeq Peptide - NP_005069
RefSeq Peptide - NP_001098662
RefSeq Peptide - NP_001269908
RefSeq Peptide - NP_001269909
swissprot - H0YLW9
swissprot - H0YNI7
swissprot - H0YNT2
swissprot - F5H7D6
swissprot - Q04726
swissprot - Q672R2
swissprot - A0A0D9SES8
swissprot - H3BUH5
swissprot - H0YKH0
swissprot - H0YKH5
swissprot - H0YKN8
swissprot - H0YKT5
swissprot - H0YL70
swissprot - H0YLI3
Ensembl - ENSG00000140332
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tle3aENSDARG00000002787Danio rerio
 tle3bENSDARG00000069006Danio rerio
 TLE3ENSGALG00000008120Gallus gallus
 Tle3ENSMUSG00000032280Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLE4 / Q04727 / transducin like enhancer of split 4ENSG0000010682983
TLE1 / Q04724 / transducin like enhancer of split 1ENSG0000019678180
TLE2 / Q04725 / transducin like enhancer of split 2ENSG0000006571766
TLE7 / transducin like enhancer of split family member 7ENSG0000026073419
TLE6 / Q9H808 / transducin like enhancer of split 6ENSG0000010495318
AES / Q08117 / amino-terminal enhancer of splitENSG0000010496416


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR005617  Groucho/TLE, N-terminal Q-rich domain
 IPR009146  Groucho/transducin-like enhancer
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:1990907 beta-catenin-TCF complex IDA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065717 TLE2 / Q04725 / transducin like enhancer of split 2  / reaction
 ENSG00000106829 TLE4 / Q04727 / transducin like enhancer of split 4  / reaction
 ENSG00000138795 LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1  / complex / reaction
 ENSG00000148737 Q9NQB0 / TCF7L2 / transcription factor 7 like 2  / complex / reaction
 ENSG00000140332 TLE3 / Q04726 / transducin like enhancer of split 3  / reaction / complex
 ENSG00000104964 AES / Q08117 / amino-terminal enhancer of split  / complex / reaction
 ENSG00000101966 XIAP / P98170 / X-linked inhibitor of apoptosis  / reaction / complex
 ENSG00000114315 HES1 / Q14469 / hes family bHLH transcription factor 1  / reaction / complex
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / complex / reaction
 ENSG00000196781 TLE1 / Q04724 / transducin like enhancer of split 1  / reaction






 

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