ENSG00000114315


Homo sapiens

Features
Gene ID: ENSG00000114315
  
Biological name :HES1
  
Synonyms : HES1 / hes family bHLH transcription factor 1 / Q14469
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q29
Gene start: 194136145
Gene end: 194138732
  
Corresponding Affymetrix probe sets: 203393_at (Human Genome U133 Plus 2.0 Array)   203394_s_at (Human Genome U133 Plus 2.0 Array)   203395_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000232424
NCBI entrez gene - 3280     See in Manteia.
OMIM - 139605
RefSeq - NM_005524
RefSeq Peptide - NP_005515
swissprot - Q14469
Ensembl - ENSG00000114315
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 her6ENSDARG00000006514Danio rerio
 Hes1ENSMUSG00000022528Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HES4 / Q9HCC6 / hes family bHLH transcription factor 4ENSG0000018829043
HES2 / Q9Y543 / hes family bHLH transcription factor 2ENSG0000006981226
HES6 / Q96HZ4 / hes family bHLH transcription factor 6ENSG0000014448521


Protein motifs (from Interpro)
Interpro ID Name
 IPR003650  Orange domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0003143 embryonic heart tube morphogenesis IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003266 regulation of secondary heart field cardioblast proliferation IEA
 biological_processGO:0003281 ventricular septum development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0021555 midbrain-hindbrain boundary morphogenesis IEA
 biological_processGO:0021557 oculomotor nerve development IEA
 biological_processGO:0021558 trochlear nerve development IEA
 biological_processGO:0021575 hindbrain morphogenesis IEA
 biological_processGO:0021861 forebrain radial glial cell differentiation ISS
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0021984 adenohypophysis development IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0031016 pancreas development IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0035909 aorta morphogenesis IEA
 biological_processGO:0035910 ascending aorta morphogenesis IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042491 inner ear auditory receptor cell differentiation IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042668 auditory receptor cell fate determination IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045598 regulation of fat cell differentiation IEA
 biological_processGO:0045607 regulation of inner ear auditory receptor cell differentiation IEA
 biological_processGO:0045608 negative regulation of inner ear auditory receptor cell differentiation IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045977 positive regulation of mitotic cell cycle, embryonic IEA
 biological_processGO:0046331 lateral inhibition IEA
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IEA
 biological_processGO:0048469 cell maturation IEA
 biological_processGO:0048505 regulation of timing of cell differentiation IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048667 cell morphogenesis involved in neuron differentiation IEA
 biological_processGO:0048711 positive regulation of astrocyte differentiation IEA
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation IEA
 biological_processGO:0048844 artery morphogenesis IEA
 biological_processGO:0050678 regulation of epithelial cell proliferation IEA
 biological_processGO:0050767 regulation of neurogenesis IEA
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IEA
 biological_processGO:0060164 regulation of timing of neuron differentiation IEA
 biological_processGO:0060253 negative regulation of glial cell proliferation IEA
 biological_processGO:0060412 ventricular septum morphogenesis IEA
 biological_processGO:0060675 ureteric bud morphogenesis IEA
 biological_processGO:0060716 labyrinthine layer blood vessel development IEA
 biological_processGO:0061009 common bile duct development IEA
 biological_processGO:0061106 negative regulation of stomach neuroendocrine cell differentiation IEA
 biological_processGO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis IEA
 biological_processGO:0061626 pharyngeal arch artery morphogenesis IEA
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0072012 glomerulus vasculature development IEA
 biological_processGO:0072049 comma-shaped body morphogenesis IEA
 biological_processGO:0072050 S-shaped body morphogenesis IEA
 biological_processGO:0072141 renal interstitial fibroblast development IEA
 biological_processGO:0072282 metanephric nephron tubule morphogenesis IEA
 biological_processGO:0090102 cochlea development IEA
 biological_processGO:0090162 establishment of epithelial cell polarity IEA
 biological_processGO:0097084 vascular smooth muscle cell development IEA
 biological_processGO:0097150 neuronal stem cell population maintenance IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 biological_processGO:2000227 negative regulation of pancreatic A cell differentiation IEA
 biological_processGO:2000737 negative regulation of stem cell differentiation IMP
 biological_processGO:2000974 negative regulation of pro-B cell differentiation IMP
 biological_processGO:2000978 negative regulation of forebrain neuron differentiation ISS
 biological_processGO:2000981 negative regulation of inner ear receptor cell differentiation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding NAS
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0071820 N-box binding IEA


Pathways (from Reactome)
Pathway description
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
RUNX2 regulates osteoblast differentiation
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000124813 RUNX2 / Q13950 / runt related transcription factor 2  / complex / reaction
 ENSG00000065717 TLE2 / Q04725 / transducin like enhancer of split 2  / complex / reaction
 ENSG00000106829 TLE4 / Q04727 / transducin like enhancer of split 4  / reaction / complex
 ENSG00000140332 TLE3 / Q04726 / transducin like enhancer of split 3  / complex / reaction
 ENSG00000196781 TLE1 / Q04724 / transducin like enhancer of split 1  / reaction / complex






 

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