ENSMUSG00000022528


Mus musculus

Features
Gene ID: ENSMUSG00000022528
  
Biological name :Hes1
  
Synonyms : Hes1 / P35428 / Transcription factor HES-1
  
Possible biological names infered from orthology : hes family bHLH transcription factor 1 / Q14469
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B2
Gene start: 30064384
Gene end: 30067796
  
Corresponding Affymetrix probe sets: 10434925 (MoGene1.0st)   1418102_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023171
NCBI entrez gene - 15205     See in Manteia.
MGI - MGI:104853
RefSeq - NM_008235
RefSeq Peptide - NP_032261
swissprot - P35428
swissprot - Q3UZZ2
Ensembl - ENSMUSG00000022528
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 her6ENSDARG00000006514Danio rerio
 HES1ENSG00000114315Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hes2 / O54792 / Transcription factor HES-2 / Q9Y543* / hes family bHLH transcription factor 2*ENSMUSG0000002894024
Hes6 / Q9JHE6 / Transcription cofactor HES-6 / Q96HZ4* / hes family bHLH transcription factor 6*ENSMUSG0000006707119


Protein motifs (from Interpro)
Interpro ID Name
 IPR003650  Orange domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0001889 liver development IMP
 biological_processGO:0003143 embryonic heart tube morphogenesis IMP
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0003266 regulation of secondary heart field cardioblast proliferation IMP
 biological_processGO:0003281 ventricular septum development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IGI
 biological_processGO:0007155 cell adhesion IGI
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007224 smoothened signaling pathway IDA
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0016477 cell migration IGI
 biological_processGO:0021537 telencephalon development IMP
 biological_processGO:0021555 midbrain-hindbrain boundary morphogenesis IGI
 biological_processGO:0021557 oculomotor nerve development IGI
 biological_processGO:0021558 trochlear nerve development IGI
 biological_processGO:0021575 hindbrain morphogenesis IGI
 biological_processGO:0021861 forebrain radial glial cell differentiation ISS
 biological_processGO:0021915 neural tube development IGI
 biological_processGO:0021983 pituitary gland development IMP
 biological_processGO:0021984 adenohypophysis development IMP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030513 positive regulation of BMP signaling pathway IGI
 biological_processGO:0030901 midbrain development IGI
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0031018 endocrine pancreas development TAS
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0035909 aorta morphogenesis IMP
 biological_processGO:0035910 ascending aorta morphogenesis IMP
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0042491 inner ear auditory receptor cell differentiation IMP
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0042668 auditory receptor cell fate determination IMP
 biological_processGO:0043388 positive regulation of DNA binding IDA
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0045596 negative regulation of cell differentiation IMP
 biological_processGO:0045598 regulation of fat cell differentiation IMP
 biological_processGO:0045607 regulation of inner ear auditory receptor cell differentiation IGI
 biological_processGO:0045608 negative regulation of inner ear auditory receptor cell differentiation IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045747 positive regulation of Notch signaling pathway IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0045977 positive regulation of mitotic cell cycle, embryonic IMP
 biological_processGO:0046331 lateral inhibition IMP
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IDA
 biological_processGO:0048469 cell maturation IGI
 biological_processGO:0048505 regulation of timing of cell differentiation IMP
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048667 cell morphogenesis involved in neuron differentiation IGI
 biological_processGO:0048711 positive regulation of astrocyte differentiation IDA
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation IDA
 biological_processGO:0048844 artery morphogenesis IMP
 biological_processGO:0050678 regulation of epithelial cell proliferation IGI
 biological_processGO:0050767 regulation of neurogenesis IGI
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IGI
 biological_processGO:0060164 regulation of timing of neuron differentiation IMP
 biological_processGO:0060253 negative regulation of glial cell proliferation IDA
 biological_processGO:0060412 ventricular septum morphogenesis IMP
 biological_processGO:0060675 ureteric bud morphogenesis IEP
 biological_processGO:0060716 labyrinthine layer blood vessel development IMP
 biological_processGO:0061009 common bile duct development IMP
 biological_processGO:0061106 negative regulation of stomach neuroendocrine cell differentiation IMP
 biological_processGO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis IMP
 biological_processGO:0061626 pharyngeal arch artery morphogenesis IMP
 biological_processGO:0065003 protein-containing complex assembly IDA
 biological_processGO:0072012 glomerulus vasculature development IEP
 biological_processGO:0072049 comma-shaped body morphogenesis IEP
 biological_processGO:0072050 S-shaped body morphogenesis IEP
 biological_processGO:0072141 renal interstitial fibroblast development IEP
 biological_processGO:0072282 metanephric nephron tubule morphogenesis IEP
 biological_processGO:0090102 cochlea development IMP
 biological_processGO:0090162 establishment of epithelial cell polarity IGI
 biological_processGO:0097084 vascular smooth muscle cell development IMP
 biological_processGO:0097150 neuronal stem cell population maintenance IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 biological_processGO:2000227 negative regulation of pancreatic A cell differentiation IMP
 biological_processGO:2000737 negative regulation of stem cell differentiation IEA
 biological_processGO:2000974 negative regulation of pro-B cell differentiation IEA
 biological_processGO:2000978 negative regulation of forebrain neuron differentiation ISS
 biological_processGO:2000981 negative regulation of inner ear receptor cell differentiation IMP
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding NAS
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0051087 chaperone binding IDA
 molecular_functionGO:0071820 N-box binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000034 abnormal vestibule morphology "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000633 abnormal pituitary gland morphology "anomalous structure of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001062 absent oculomotor nerve "missing nerve of the extraocular muscles, iris and ciliary body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001064 absent trochlear nerve "missing nerve of the superior oblique muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001328 disorganized retinal layers "delaminated or mispositioned sheets of cells comprising the optic part of the retina" [J:33400]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001890 anencephaly "absence of the bones of the cranial vault and absent or rudimentary cerebral and cerebellar hemispheres, brainstem, and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:31571]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Gja1tm3Gfi/Gja1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002653 abnormal ependyma morphology "malformation or absence of the cellular membrane that lines the brain ventricles and the central canal of the spinal cord" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002659 pituitary gland hypoplasia "decreased size of pituitary gland due to decreased cell number" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il23atm1Ngh/Il23atm1Ngh
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Fgu/Hes1tm1Hojo,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002691 small stomach "reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc6a3tm1.1Jaja/Slc6a3tm1.1Jaja
Genetic Background: B6.129-Slc6a3tm1.1Jaja

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il23atm1Ngh/Il23atm1Ngh
Genetic Background: involves: 129 * C57BL/6

 MP:0002929 abnormal bile duct development "incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0003250 absent gall bladder "absence of the organ which serves as a storage reservoir for bile" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003424 premature neuronal precursor differentiation "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003647 absent oligodendrocytes "absence of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003661 abnormal locus ceruleus "anomaly in a dense cluster of neurons within the dorsorostral pons; it is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic" [J:96328, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0003816 abnormal pituitary gland development "malformation or incomplete differentiation of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Fgu/Hes1tm1Hojo,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003817 abnormal Rathke s pouch "malformation or incomplete differentiation of a pouch of ectoderm that grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Fgu/Hes1tm1Hojo,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Hes1tm1(cre/ERT2)Lcm/Hes1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

Allelic Composition: Hes1tm1Kag/Hes1tm1Kag,Foxa2tm3.1(icre)Heli/Foxa2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0004164 abnormal neurophysis morphology "any malfomation or absence of the part of the pituitary gland that secretes hormones involved in blood pressure regulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Fgu/Hes1tm1Hojo,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm3Gfi/Gja1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004280 abnormal oculomotor nucleus morphology "any structural anomaly of the group of motor neurons in the floor of the midbrain that gives rise to motor fibers of the oculomotor nerve" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0004327 increased vestibular hair cell number "increased number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004395 increased cochlear inner hair cell number "increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004401 increased cochlear outer hair cell number "increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il23atm1Ngh/Il23atm1Ngh
Genetic Background: involves: 129 * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005220 abnormal exocrine pancreas morphology "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005603 neuron hypertrophy "increased mass of any of the structural and functional units of the nervous system, which consist of the nerve cell body, the dendrites, and the axon" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0006089 abnormal saccule morphology "malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0006090 abnormal utricle morphology "malformation in the larger of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0006292 abnormal olfactory placode morphology "any structural abnormality in the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes" [J:62024, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0006294 absent optic vesicle "absence of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [J:94391, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008328 increased somatotroph cell number "greater number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Fgu/Hes1tm1Hojo,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008367 absent pituitary intermediate lobe "absence of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Fgu/Hes1tm1Hojo,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008934 absent choroid plexus "absence of the fringe of the tela choroidea of the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008949 increased Cajal-Retzius cell number "greater number of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009159 increased pancreatic acinar cell number "increased number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Hes1tm1(cre/ERT2)Lcm/Hes1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009175 abnormal pancreatic beta cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete insulin, and/or accumulation of pancreatic beta cell precursors" [MESH:A03.734.414.131]
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Allelic Composition: Hes1tm1Kag/Hes1tm1Kag,Foxa2tm3.1(icre)Heli/Foxa2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0009463 abnormal pituitary infundibular stalk "any structural anomaly of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Fgu/Hes1tm1Hojo,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009493 abnormal cystic duct morphology "any structural anomaly of the tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0009495 abnormal common bile duct morphology "any structural anomaly of the part of the biliary tree formed by the union of the cystic duct and the common hepatic duct" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009498 abnormal extrahepatic bile duct morphology "any structural anomaly of the passages external to the liver for the conveyance of bile" [MESH:A03.159.183.079]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0010129 increased DN1 thymic pro-T cell number "increased number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]
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Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0010130 decreased DN1 thymic pro-T cell number "reduced number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]
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Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0010132 decreased DN2 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive" [CL:0000806]
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Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0010134 decreased DN3 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
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Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
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Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0010171 abnormal centroacinar cell of Langerhans morphology "any structural anomaly of cells that line the pancreatic ducts that secrete mucins and an aqueous bicarbonate solution under stimulation by the hormone secretin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Hes1tm1(cre/ERT2)Lcm/Hes1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0010268 decreased lymphoma incidence "less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Hes1tm1.1Frad/Hes1tm1.1Frad,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0010915 increased solitary pulmonary neuroendocrine cell number "increased number of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hes1tm1Fgu/Hes1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0010919 increased number of pulmonary neuroendocrine bodies "greater number of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hes1tm1Fgu/Hes1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0010949 decreased Clara cell number "reduced number of the rounded, club-shaped, nonciliated cells found between ciliated cells in bronchiolar epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Hspa5tm1Alee/Hspa5+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/?
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0012132 abnormal midbrain-hindbrain boundary morphology "any structural anomaly of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [MGI:anna]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0012686 everted embryonic neuroepithelium "an inside-out appearance of the embryonic neuroepithelium characteristic of defective primary neurulation resulting from failure of neural fold elevation; everted neural folds assume a convex instead of a concave morphology and fail to bend toward each other and fuse at the dorsal midline leading to exencephaly" [MGI:anna]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / reaction / complex






 

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