ENSG00000065717


Homo sapiens

Features
Gene ID: ENSG00000065717
  
Biological name :TLE2
  
Synonyms : Q04725 / TLE2 / transducin like enhancer of split 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 2997638
Gene end: 3047635
  
Corresponding Affymetrix probe sets: 204431_at (Human Genome U133 Plus 2.0 Array)   40837_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468666
Ensembl peptide - ENSP00000467358
Ensembl peptide - ENSP00000468279
Ensembl peptide - ENSP00000262953
Ensembl peptide - ENSP00000392427
Ensembl peptide - ENSP00000392869
Ensembl peptide - ENSP00000413107
Ensembl peptide - ENSP00000465292
Ensembl peptide - ENSP00000465519
Ensembl peptide - ENSP00000466542
Ensembl peptide - ENSP00000467337
NCBI entrez gene - 7089     See in Manteia.
OMIM - 601041
RefSeq - XM_011528230
RefSeq - NM_001144761
RefSeq - NM_001144762
RefSeq - NM_001300846
RefSeq - NM_003260
RefSeq - XM_006722864
RefSeq Peptide - NP_001287775
RefSeq Peptide - NP_003251
RefSeq Peptide - NP_001138233
RefSeq Peptide - NP_001138234
swissprot - K7EPF3
swissprot - K7ESD8
swissprot - K7EK93
swissprot - K7EMK7
swissprot - K7EPD4
swissprot - Q04725
swissprot - K7EJR7
Ensembl - ENSG00000065717
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Tle2ENSMUSG00000034771Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLE4 / Q04727 / transducin like enhancer of split 4ENSG0000010682969
TLE1 / Q04724 / transducin like enhancer of split 1ENSG0000019678169
TLE3 / Q04726 / transducin like enhancer of split 3ENSG0000014033268
TLE7 / transducin like enhancer of split family member 7ENSG0000026073421
TLE6 / Q9H808 / transducin like enhancer of split 6ENSG0000010495320
AES / Q08117 / amino-terminal enhancer of splitENSG0000010496416


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR005617  Groucho/TLE, N-terminal Q-rich domain
 IPR009146  Groucho/transducin-like enhancer
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IDA
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065717 TLE2 / Q04725 / transducin like enhancer of split 2  / reaction / complex
 ENSG00000104964 AES / Q08117 / amino-terminal enhancer of split  / complex / reaction
 ENSG00000101966 XIAP / P98170 / X-linked inhibitor of apoptosis  / reaction / complex
 ENSG00000114315 HES1 / Q14469 / hes family bHLH transcription factor 1  / complex / reaction
 ENSG00000138795 LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1  / reaction / complex
 ENSG00000140332 TLE3 / Q04726 / transducin like enhancer of split 3  / reaction
 ENSG00000148737 Q9NQB0 / TCF7L2 / transcription factor 7 like 2  / complex / reaction
 ENSG00000106829 TLE4 / Q04727 / transducin like enhancer of split 4  / reaction
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / reaction / complex
 ENSG00000196781 TLE1 / Q04724 / transducin like enhancer of split 1  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr