ENSMUSG00000034771


Mus musculus

Features
Gene ID: ENSMUSG00000034771
  
Biological name :Tle2
  
Synonyms : Q9WVB2 / Tle2 / transducin-like enhancer of split 2
  
Possible biological names infered from orthology : Q04725
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 81574561
Gene end: 81590845
  
Corresponding Affymetrix probe sets: 10365145 (MoGene1.0st)   1436244_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121125
Ensembl peptide - ENSMUSP00000120218
Ensembl peptide - ENSMUSP00000121173
Ensembl peptide - ENSMUSP00000122074
Ensembl peptide - ENSMUSP00000121585
Ensembl peptide - ENSMUSP00000114400
Ensembl peptide - ENSMUSP00000117453
Ensembl peptide - ENSMUSP00000118334
NCBI entrez gene - 21886     See in Manteia.
MGI - MGI:104635
RefSeq - XM_017313924
RefSeq - XM_011243433
RefSeq - XM_011243434
RefSeq - XM_011243435
RefSeq - XM_011243436
RefSeq - XM_011243437
RefSeq - XM_017313919
RefSeq - XM_017313920
RefSeq - XM_017313921
RefSeq - XM_017313922
RefSeq - XM_017313923
RefSeq - NM_001252401
RefSeq - NM_019725
RefSeq - XM_006513584
RefSeq - XM_006513585
RefSeq - XM_006513586
RefSeq - XM_006513588
RefSeq - XM_006513589
RefSeq - XM_011243424
RefSeq - XM_011243425
RefSeq - XM_011243426
RefSeq - XM_011243427
RefSeq - XM_011243428
RefSeq - XM_011243429
RefSeq - XM_011243430
RefSeq - XM_011243431
RefSeq - XM_011243432
RefSeq Peptide - NP_062699
RefSeq Peptide - NP_001239330
swissprot - F6X5U5
swissprot - F6YM15
swissprot - D3Z1A4
swissprot - Q9WVB2
swissprot - D3Z0X0
swissprot - E9PV07
swissprot - Q3UN01
swissprot - D3Z2J7
Ensembl - ENSMUSG00000034771
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLE2ENSG00000065717Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tle1 / Q62440 / Transducin-like enhancer protein 1 / Q04724* / transducin like enhancer of split 1*ENSMUSG0000000830566
Tle3 / Q08122 / transducin-like enhancer of split 3 / Q04726*ENSMUSG0000003228065
Tle4 / Q62441 / Transducin-like enhancer protein 4 / Q04727* / transducin like enhancer of split 4*ENSMUSG0000002464265
Tle6 / Q9WVB3 / transducin-like enhancer of split 6 / Q9H808*ENSMUSG0000003475818
Gm21964 / transducin like enhancer of split family member 7 / TLE7*ENSMUSG0000009594118
Aes / P63002 / Amino-terminal enhancer of split / Q08117*ENSMUSG0000005445215


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR005617  Groucho/TLE, N-terminal Q-rich domain
 IPR009146  Groucho/transducin-like enhancer
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025860 Xiap / Q60989 / X-linked inhibitor of apoptosis / BIRC8* / P98170* / Q96P09* / baculoviral IAP repeat containing 8*  / complex / reaction
 ENSMUSG00000032280 Tle3 / Q08122 / transducin-like enhancer of split 3 / Q04726*  / reaction
 ENSMUSG00000024642 Tle4 / Q62441 / Transducin-like enhancer protein 4 / Q04727* / transducin like enhancer of split 4*  / reaction
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / complex
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / complex
 ENSMUSG00000027985 Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*  / complex / reaction
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction
 ENSMUSG00000024985 Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*  / reaction / complex
 ENSMUSG00000008305 Tle1 / Q62440 / Transducin-like enhancer protein 1 / Q04724* / transducin like enhancer of split 1*  / reaction
 ENSMUSG00000034771 Tle2 / Q9WVB2 / transducin-like enhancer of split 2 / Q04725*  / reaction / complex






 

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