Manteia

ENSMUSG00000024642

Mus musculus

Features

Gene ID:	ENSMUSG00000024642

Biological name :	Tle4

Synonyms :	Q62441 / Tle4 / Transducin-like enhancer protein 4

Possible biological names infered from orthology :	Q04727 / transducin like enhancer of split 4

Species:	Mus musculus

Chr. number:	19
Strand:	-1
Band:	A
Gene start:	14448072
Gene end:	14598051

Corresponding Affymetrix probe sets:	10466374 (MoGene1.0st) 1425650_at (Mouse Genome 430 2.0 Array) 1430384_at (Mouse Genome 430 2.0 Array) 1450853_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000057527 Ensembl peptide - ENSMUSP00000126249 NCBI entrez gene - 21888 See in Manteia. MGI - MGI:104633 RefSeq - NM_011600 RefSeq - XM_006526914 RefSeq - NM_001302947 RefSeq - NM_001302950 RefSeq - NM_001302951 RefSeq - XM_006526913 RefSeq Peptide - NP_001289879 RefSeq Peptide - NP_001289880 RefSeq Peptide - NP_035730 RefSeq Peptide - NP_001289876 swissprot - Q62441 swissprot - F6ZBY9 Ensembl - ENSMUSG00000024642

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
TLE4Z1	ENSGALG00000015184	Gallus gallus
TLE4	ENSG00000106829	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Tle1 / Q62440 / Transducin-like enhancer protein 1 / Q04724* / transducin like enhancer of split 1*	ENSMUSG00000008305	86
Tle3 / Q08122 / transducin-like enhancer of split 3 / Q04726*	ENSMUSG00000032280	83
Tle2 / Q9WVB2 / transducin-like enhancer of split 2 / Q04725*	ENSMUSG00000034771	65
Aes / P63002 / Amino-terminal enhancer of split / Q08117*	ENSMUSG00000054452	18
Gm21964 / transducin like enhancer of split family member 7 / TLE7*	ENSMUSG00000095941	17
Tle6 / Q9WVB3 / transducin-like enhancer of split 6 / Q9H808*	ENSMUSG00000034758	17

Protein motifs (from Interpro)

Interpro ID	Name
IPR001680	WD40 repeat
IPR005617	Groucho/TLE, N-terminal Q-rich domain
IPR009146	Groucho/transducin-like enhancer
IPR015943	WD40/YVTN repeat-like-containing domain superfamily
IPR017986	WD40-repeat-containing domain
IPR019775	WD40 repeat, conserved site
IPR036322	WD40-repeat-containing domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0016055	Wnt signaling pathway	IDA
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	IDA
biological_process	GO:1990830	cellular response to leukemia inhibitory factor	IEP
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:1990907	beta-catenin-TCF complex	IEA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	IGI
molecular_function	GO:0003714	transcription corepressor activity	IGI
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0070491	repressing transcription factor binding	IPI

Pathways (from Reactome)

Pathway description

Formation of the beta-catenin:TCF transactivating complex

Deactivation of the beta-catenin transactivating complex

Repression of WNT target genes

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0000165	abnormal hypertrophic chondrocyte zone	"anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0000333	decreased bone marrow cell number	"decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0000694	spleen hypoplasia	"small size due to reduced cell number in the spleen" [J:43971]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0000703	abnormal thymus morphology	"anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0002401	abnormal lymphopoiesis	"atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0003055	abnormal epiphyseal plate morphology	"malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0003644	thymus atrophy	"wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0003662	abnormal proliferative zone	"germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0004810	decreased hematopoietic stem cell number	"reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0006396	decreased long bone epiphyseal plate size	"reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0008039	increased NK T cell number	"greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0008174	decreased follicular B cell number	"reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0008470	abnormal spleen B cell follicle morphology	"any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0008813	decreased common myeloid progenitor cell number	"reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0009541	increased thymocyte apoptosis	"increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0010132	decreased DN2 thymocyte number	"reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive" [CL:0000806]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0010763	abnormal hematopoietic stem cell physiology	"any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0010873	decreased trabecular bone mass	"reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N
MP:0011816	decreased pre-pro B cell number	"reduced number of pro-B cells that are CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative; this cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive" [CL:0002045, MGI:csmith]	Show Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm} Genetic Background: involves: 129S2/SvPas * C57BL/6N

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000025860	Xiap / Q60989 / X-linked inhibitor of apoptosis / BIRC8* / P98170* / Q96P09* / baculoviral IAP repeat containing 8*	/ complex / reaction
ENSMUSG00000006932	Ctnnb1 / Q02248 / Catenin beta-1 / P35222*	/ reaction
ENSMUSG00000024985	Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*	/ reaction / complex
ENSMUSG00000032280	Tle3 / Q08122 / transducin-like enhancer of split 3 / Q04726*	/ reaction
ENSMUSG00000027985	Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*	/ complex / reaction
ENSMUSG00000034771	Tle2 / Q9WVB2 / transducin-like enhancer of split 2 / Q04725*	/ reaction
ENSMUSG00000008305	Tle1 / Q62440 / Transducin-like enhancer protein 1 / Q04724* / transducin like enhancer of split 1*	/ reaction
ENSMUSG00000024642	Tle4 / Q62441 / Transducin-like enhancer protein 4 / Q04727* / transducin like enhancer of split 4*	/ complex / reaction
ENSMUSG00000061062	Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*	/ complex
ENSMUSG00000028800	Hdac1 / O09106 / Histone deacetylase 1 / Q13547*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr