ENSMUSG00000027985


Mus musculus

Features
Gene ID: ENSMUSG00000027985
  
Biological name :Lef1
  
Synonyms : Lef1 / Lymphoid enhancer-binding factor 1 / P27782
  
Possible biological names infered from orthology : Q9UJU2
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 131110471
Gene end: 131224356
  
Corresponding Affymetrix probe sets: 10496091 (MoGene1.0st)   1421299_a_at (Mouse Genome 430 2.0 Array)   1454734_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029611
Ensembl peptide - ENSMUSP00000067808
Ensembl peptide - ENSMUSP00000096211
Ensembl peptide - ENSMUSP00000101948
NCBI entrez gene - 16842     See in Manteia.
MGI - MGI:96770
RefSeq - XM_006501070
RefSeq - NM_001276402
RefSeq - NM_001276403
RefSeq - NM_010703
RefSeq - XM_006501068
RefSeq - XM_006501069
RefSeq Peptide - NP_034833
RefSeq Peptide - NP_001263331
RefSeq Peptide - NP_001263332
swissprot - Q8BGZ9
swissprot - Q8C402
swissprot - D3Z654
swissprot - P27782
swissprot - Q3TYB0
Ensembl - ENSMUSG00000027985
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lef1ENSDARG00000031894Danio rerio
 LEF1ENSGALG00000031960Gallus gallus
 LEF1ENSG00000138795Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*ENSMUSG0000002498563
Tcf7l1 / transcription factor 7 like 1 / Q9HCS4*ENSMUSG0000005579956
Tcf7 / Q00417 / transcription factor 7, T cell specific / P36402* / transcription factor 7*ENSMUSG0000000078238


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR013558  CTNNB1 binding, N-teminal
 IPR024940  Transcription factor TCF/LEF
 IPR027397  Catenin binding domain superfamily
 IPR028769  Lymphoid enhancer-binding factor 1
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001755 neural crest cell migration IBA
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021542 dentate gyrus development IMP
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0021854 hypothalamus development IBA
 biological_processGO:0021861 forebrain radial glial cell differentiation IGI
 biological_processGO:0021873 forebrain neuroblast division IGI
 biological_processGO:0021879 forebrain neuron differentiation IBA
 biological_processGO:0021943 formation of radial glial scaffolds IGI
 biological_processGO:0022407 regulation of cell-cell adhesion IMP
 biological_processGO:0022408 negative regulation of cell-cell adhesion ISO
 biological_processGO:0022409 positive regulation of cell-cell adhesion ISO
 biological_processGO:0030111 regulation of Wnt signaling pathway IGI
 biological_processGO:0030223 neutrophil differentiation IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030326 embryonic limb morphogenesis IGI
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030509 BMP signaling pathway IDA
 biological_processGO:0030854 positive regulation of granulocyte differentiation IEA
 biological_processGO:0030879 mammary gland development IMP
 biological_processGO:0032696 negative regulation of interleukin-13 production IEA
 biological_processGO:0032713 negative regulation of interleukin-4 production IEA
 biological_processGO:0032714 negative regulation of interleukin-5 production IEA
 biological_processGO:0033153 T cell receptor V(D)J recombination IGI
 biological_processGO:0042100 B cell proliferation IMP
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043586 tongue development IMP
 biological_processGO:0043923 positive regulation by host of viral transcription IEA
 biological_processGO:0043966 histone H3 acetylation IEA
 biological_processGO:0043967 histone H4 acetylation IEA
 biological_processGO:0045063 T-helper 1 cell differentiation IDA
 biological_processGO:0045843 negative regulation of striated muscle tissue development IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046632 alpha-beta T cell differentiation IGI
 biological_processGO:0048069 eye pigmentation IBA
 biological_processGO:0048341 paraxial mesoderm formation IGI
 biological_processGO:0048468 cell development IGI
 biological_processGO:0048747 muscle fiber development IBA
 biological_processGO:0050909 sensory perception of taste IMP
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060033 anatomical structure regression IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060325 face morphogenesis IGI
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0060561 apoptotic process involved in morphogenesis IMP
 biological_processGO:0060710 chorio-allantoic fusion IGI
 biological_processGO:0061153 trachea gland development IMP
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:0071353 cellular response to interleukin-4 IEA
 biological_processGO:0071864 positive regulation of cell proliferation in bone marrow IEA
 biological_processGO:0071866 negative regulation of apoptotic process in bone marrow IEA
 biological_processGO:0071895 odontoblast differentiation IBA
 biological_processGO:0071899 negative regulation of estrogen receptor binding IEA
 biological_processGO:0090068 positive regulation of cell cycle process ISO
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1902262 apoptotic process involved in blood vessel morphogenesis IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:1990907 beta-catenin-TCF complex IC
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IGI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008301 DNA binding, bending IDA
 molecular_functionGO:0030284 estrogen receptor activity IEA
 molecular_functionGO:0030331 estrogen receptor binding IEA
 molecular_functionGO:0035326 enhancer binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0045295 gamma-catenin binding IEA
 molecular_functionGO:0070016 armadillo repeat domain binding IEA
 molecular_functionGO:0070742 C2H2 zinc finger domain binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Ca2+ pathway
Repression of WNT target genes
RUNX3 regulates WNT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000094 absent alveolar process "missing projecting ridge on the inferior surface of the body of the maxilla containing the tooth sockets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000118 arrest of tooth development "failure of differentiation of the teeth" [J:18378]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000124 absent teeth "missing bony structures of the upper and lower jaws used in mastication" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000125 absent incisors "missing long pointed teeth; most anterior and prominent in the jaw" [J:17489]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000394 absent melanin granules in hair follicle "missing pigment polymers in the hair follicles" [J:18378]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000448 pointed snout "nose tapers to a small tip, sharper angle than wild type " [J:18378]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000629 absent mammary gland "missing milk-secreting glands of the breast" [J:18378]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000809 absent hippocampus "missing convoluted brain structure below the cerebral hemispheres; forms part of the limbic system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000814 absent dentate gyrus "lack of the section of the hippocampus normally situated above the gyrus hippocampi and composed of three layers, the molecular, granular, and polymorphic layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Lef1tm1Rug/Lef1tm1Rug
Genetic Background: involves: 129S2/SvPas

 MP:0000862 absent barrels in primary somatosensory cortex "missing pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:64064]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000908 absent mesencephalic trigeminal nucleus "missing group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18378]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000936 small telencephalic vesicles "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0001677 absent apical ectodermal ridge "missing the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [J:54637]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0003931 absent molars "missing the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0004790 absent upper incisors "missing the upper pair of long pointed teeth that are the most anterior and prominent in the jaw" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0004791 absent lower incisors "missing the lower pair of long pointed teeth that are the most anterior and prominent in the jaw" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0006302 abnormal ectomesenchyme morphology "abnormality in the mesenchymal cells derived from neural crest cells that contribute to development of the hard and soft tissue in the head and neck, including the branchial arches." [J:119939, mnk:Michelle Knowlton_MGI Curator]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008051 abnormal memory T cell physiology "any functional anomaly of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: HhatTg(TFAP2A-cre)1Will/HhatTg(TFAP2A-cre)1Will
Genetic Background: Not Specified

Allelic Composition: Lef1tm1Hhx/Lef1tm1Hhx,Tcf7tm1Cle/Tcf7tm1Cle,Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Tg(GZMB-cre)1Jcb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Lef1tm1Hhx/Lef1tm1Hhx,Tg(GZMB-cre)1Jcb/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Lef1tm1Hhx/Lef1tm1Hhx,Tcf7tm1Cle/Tcf7tm1Cle,Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Tg(GZMB-cre)1Jcb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0008262 abnormal hippocampus region morphology "any structural anomaly of a part or parts of the hippocampus that have a particular function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lef1tm1Rug/Lef1tm1Rug
Genetic Background: involves: 129S2/SvPas

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Lef1tm1Hhx/Lef1tm1Hhx,Tcf7tm1Cle/Tcf7tm1Cle,Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Tg(GZMB-cre)1Jcb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0008843 absent subcutaneous adipose tissue "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0009097 absent endometrial glands "absence of the simple or branched tubular uterine glands" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp3tm3(DTR/GFP)Ayr/Foxp3+,Gpr174tm1Cys/Gpr174+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0013166 small forelimb buds "reduced size of the limb bud that normally develops into a forelimb (usually the arm or front limb in mammalian species)" [MGI:anna]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0013400 abnormal endometrial gland development "aberrant formation or incomplete differentiation of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:Anna, PMID:23619340]
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Allelic Composition: Foxp3tm3(DTR/GFP)Ayr/Foxp3+,Gpr174tm1Cys/Gpr174+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0013785 abnormal mammary gland bud morphology "any structural anomaly of the morphologically distinct bulb of epithelial cells formed once each mammary placode expands and invaginates into the underlying mesenchyme; in mouse embryos at E12.5, each epithelial bud with its contiguous mesenchyme is elevated above the surrounding ectoderm as a knob or dome; at E13.5, the buds sink into the underlying dermal mesenchyme, and by E14.5 they can no longer be detected externally; in female mouse embryos, five pairs of anlagen or buds are formed along the mammary line between E12.5 and E14.5 by proliferation of basal epidermal cells; while further mammary development is temporarily arrested in females, androgen receptor activation in male embryos causes degeneration of the buds between E13.5 and E15.5; in female mice, further development is resumed at around E15.5 when each bud elongates to form a mammary cord (sprout), invading the underlying fat pad precursor" [http://www.informatics.jax.org/greenbook/frames/frame13.shtml, MGI:Anna, PMID:12558599]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021611 Tert / O70372 / telomerase reverse transcriptase / O14746*  / complex / reaction
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction / complex
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / complex / reaction
 ENSMUSG00000034910 Pygo1 / Q9D0P5 / pygopus 1 / Q9Y3Y4* / pygopus family PHD finger 1*  / reaction / complex
 ENSMUSG00000076431 Sox4 / Q06831 / Transcription factor SOX-4 / Q06945* / SRY-box 4*  / complex / reaction
 ENSMUSG00000025902 Sox17 / Q61473 / Transcription factor SOX-17 / Q9H6I2* / SRY-box 17*  / complex / reaction
 ENSMUSG00000038256 Bcl9 / Q9D219 / B-cell CLL/lymphoma 9 protein / O00512* / B cell CLL/lymphoma 9*  / reaction / complex
 ENSMUSG00000032187 Q3TKT4 / Smarca4 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 / P51532*  / complex / reaction
 ENSMUSG00000070643 Sox13 / Q04891 / Transcription factor SOX-13 / Q9UN79* / SRY-box 13*  / complex / reaction
 ENSMUSG00000026361 Cdc73 / Q8JZM7 / Parafibromin / Q6P1J9* / cell division cycle 73*  / complex / reaction
 ENSMUSG00000047824 Pygo2 / pygopus 2 / Q9BRQ0* / pygopus family PHD finger 2*  / reaction / complex
 ENSMUSG00000063382 Bcl9l / Q67FY2 / Mus musculus B cell CLL/lymphoma 9-like (Bcl9l), transcript variant 2, mRNA. / Q86UU0* / B cell CLL/lymphoma 9 like*  / complex / reaction
 ENSMUSG00000042487 Leo1 / Q5XJE5 / RNA polymerase-associated protein LEO1 / Q8WVC0* / LEO1 homolog, Paf1/RNA polymerase II complex component*  / complex / reaction
 ENSMUSG00000030079 P60122 / Ruvbl1 / RuvB-like protein 1 / Q9Y265* / RuvB like AAA ATPase 1*  / reaction / complex
 ENSMUSG00000008305 Tle1 / Q62440 / Transducin-like enhancer protein 1 / Q04724* / transducin like enhancer of split 1*  / reaction / complex
 ENSMUSG00000032280 Tle3 / Q08122 / transducin-like enhancer of split 3 / Q04726*  / complex / reaction
 ENSMUSG00000024642 Tle4 / Q62441 / Transducin-like enhancer protein 4 / Q04727* / transducin like enhancer of split 4*  / complex / reaction
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / complex
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / complex
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / complex / reaction
 ENSMUSG00000034771 Tle2 / Q9WVB2 / transducin-like enhancer of split 2 / Q04725*  / reaction / complex
 ENSMUSG00000017376 Nlk / O54949 / Serine/threonine-protein kinase NLK / Q9UBE8* / nemo like kinase*  / reaction






 

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