ENSMUSG00000030079


Mus musculus

Features
Gene ID: ENSMUSG00000030079
  
Biological name :Ruvbl1
  
Synonyms : P60122 / Ruvbl1 / RuvB-like protein 1
  
Possible biological names infered from orthology : Q9Y265 / RuvB like AAA ATPase 1
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: D1
Gene start: 88465409
Gene end: 88497572
  
Corresponding Affymetrix probe sets: 10539882 (MoGene1.0st)   1416585_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117925
Ensembl peptide - ENSMUSP00000032165
NCBI entrez gene - 56505     See in Manteia.
MGI - MGI:1928760
RefSeq - NM_019685
RefSeq Peptide - NP_062659
swissprot - D3YW60
swissprot - P60122
swissprot - Q3U1C2
Ensembl - ENSMUSG00000030079
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ruvbl1ENSDARG00000002591Danio rerio
 RUVBL1ENSGALG00000005931Gallus gallus
 Q9Y265ENSG00000175792Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR010339  TIP49, C-terminal
 IPR012340  Nucleic acid-binding, OB-fold
 IPR027238  RuvB-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000492 box C/D snoRNP assembly IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016573 histone acetylation IBA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043967 histone H4 acetylation IEA
 biological_processGO:0043968 histone H2A acetylation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 biological_processGO:1904874 positive regulation of telomerase RNA localization to Cajal body IEA
 cellular_componentGO:0000812 Swr1 complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031011 Ino80 complex IEA
 cellular_componentGO:0035267 NuA4 histone acetyltransferase complex IEA
 cellular_componentGO:0071339 MLL1 complex IEA
 cellular_componentGO:0097255 R2TP complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001094 TFIID-class transcription factor binding IPI
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0017025 TBP-class protein binding IEA
 molecular_functionGO:0043141 ATP-dependent 5"-3" DNA helicase activity IEA
 molecular_functionGO:0043531 ADP binding IDA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0051117 ATPase binding IPI


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
UCH proteinases
Ub-specific processing proteases
DNA Damage Recognition in GG-NER
Deposition of new CENPA-containing nucleosomes at the centromere


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011695 absent hematopoietic stem cells "absence of the multipotent, self-renewing stem cells found in the bone marrow, yolk sac and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0012113 decreased inner cell mass proliferation 
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Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0012128 abnormal blastocyst formation "atypical formation of a blastocyst from a solid ball of cells known as a morula, including anomalies in the formation of a fluid-filled cavity (blastocoele) and/or initiation of inner cell mass and trophectoderm differentiation" [MGI:anna]
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Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0013776 bone marrow failure "inherited or acquired dysfunction of hematopoietic stem cells that can result in abnormalities in one or more of the stem cell lineages (erythroid, myeloid, megakaryocytic)" [http://emedicine.medscape.com/article/199003-overview, MGI:llw2]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027985 Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*  / complex / reaction
 ENSMUSG00000020708 Psmc5 / P62196 / protease (prosome, macropain) 26S subunit, ATPase 5 / P62195* / proteasome 26S subunit, ATPase 5*  / complex
 ENSMUSG00000027793 Ccna1 / Q61456 / Cyclin-A1 / P78396*  / complex
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / reaction / complex
 ENSMUSG00000024985 Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*  / reaction / complex
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction / complex
 ENSMUSG00000033364 Usp37 / Q8C0R0 / ubiquitin specific peptidase 37 / Q86T82*  / complex
 ENSMUSG00000027715 Ccna2 / P51943 / Cyclin-A2 / P20248*  / complex






 

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