ENSMUSG00000027715


Mus musculus

Features
Gene ID: ENSMUSG00000027715
  
Biological name :Ccna2
  
Synonyms : Ccna2 / Cyclin-A2 / P51943
  
Possible biological names infered from orthology : P20248
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: B
Gene start: 36564865
Gene end: 36572150
  
Corresponding Affymetrix probe sets: 10497831 (MoGene1.0st)   1417910_at (Mouse Genome 430 2.0 Array)   1417911_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029270
Ensembl peptide - ENSMUSP00000142946
Ensembl peptide - ENSMUSP00000118239
NCBI entrez gene - 12428     See in Manteia.
MGI - MGI:108069
RefSeq - NM_009828
RefSeq - XM_017319444
RefSeq Peptide - NP_033958
swissprot - D6RIK7
swissprot - P51943
swissprot - A0A0G2JEY1
Ensembl - ENSMUSG00000027715
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccna2ENSDARG00000011094Danio rerio
 CCNA2ENSGALG00000011881Gallus gallus
 CCNA2ENSG00000145386Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccna1 / Q61456 / Cyclin-A1 / P78396*ENSMUSG0000002779347
Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*ENSMUSG0000004143127
Ccnb3 / Q8WWL7* / cyclin B3*ENSMUSG0000005159226
Ccnb2 / P30276 / G2/mitotic-specific cyclin-B2 / O95067* / cyclin B2*ENSMUSG0000003221823
Ccno / P0C242 / Cyclin-O / P22674*ENSMUSG0000004241719
Ccne1 / Q61457 / G1/S-specific cyclin-E1 / P24864* / cyclin E1*ENSMUSG0000000206819
Ccne2 / Q9Z238 / G1/S-specific cyclin-E2 / O96020* / cyclin E2*ENSMUSG0000002821218
Ccnd3 / P30282 / G1/S-specific cyclin-D3 / P30281* / cyclin D3*ENSMUSG0000003416515
Ccnd2 / P30280 / G1/S-specific cyclin-D2 / P30279* / cyclin D2*ENSMUSG0000000018415
Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*ENSMUSG0000007034814


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR032447  Cyclin-A, N-terminal
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0016572 histone phosphorylation IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0033762 response to glucagon IEA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0044320 cellular response to leptin stimulus IEA
 biological_processGO:0044843 cell cycle G1/S phase transition IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0071314 cellular response to cocaine IEA
 biological_processGO:0071373 cellular response to luteinizing hormone stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071732 cellular response to nitric oxide IEA
 biological_processGO:0090102 cochlea development IEA
 biological_processGO:1990314 cellular response to insulin-like growth factor stimulus IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IEA
 cellular_componentGO:0001939 female pronucleus IDA
 cellular_componentGO:0001940 male pronucleus IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0097124 cyclin A2-CDK2 complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0097472 cyclin-dependent protein kinase activity IEA


Pathways (from Reactome)
Pathway description
G0 and Early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cbfbtm4Ppl/Cbfb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cbfbtm4Ppl/Cbfb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mtdhtm1.2Dsar/Mtdhtm1.2Dsar
Genetic Background: either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Mtdhtm1.2Dsar/Mtdhtm1.2Dsar
Genetic Background: either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

Allelic Composition: Ccna2tm1.1Pisc/Ccna2tm1.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbfbtm4Ppl/Cbfb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Cbfbtm4Ppl/Cbfb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.1Pisc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

Allelic Composition: Ccna2tm1Sot/Ccna2tm1Sot
Genetic Background: involves: 129P2/OlaHsd * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020708 Psmc5 / P62196 / protease (prosome, macropain) 26S subunit, ATPase 5 / P62195* / proteasome 26S subunit, ATPase 5*  / complex
 ENSMUSG00000030079 P60122 / Ruvbl1 / RuvB-like protein 1 / Q9Y265* / RuvB like AAA ATPase 1*  / complex
 ENSMUSG00000033364 Usp37 / Q8C0R0 / ubiquitin specific peptidase 37 / Q86T82*  / complex






 

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