ENSMUSG00000032218


Mus musculus

Features
Gene ID: ENSMUSG00000032218
  
Biological name :Ccnb2
  
Synonyms : Ccnb2 / G2/mitotic-specific cyclin-B2 / P30276
  
Possible biological names infered from orthology : cyclin B2 / O95067
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: D
Gene start: 70407692
Gene end: 70421547
  
Corresponding Affymetrix probe sets: 10594774 (MoGene1.0st)   1450920_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034742
NCBI entrez gene - 12442     See in Manteia.
MGI - MGI:88311
RefSeq - NM_007630
RefSeq Peptide - NP_031656
swissprot - P30276
Ensembl - ENSMUSG00000032218
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccnb2ENSDARG00000036180Danio rerio
 CCNB2ENSGALG00000004161Gallus gallus
 CCNB2ENSG00000157456Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*ENSMUSG0000004143153
Ccna1 / Q61456 / Cyclin-A1 / P78396*ENSMUSG0000002779328
Ccnb3 / Q8WWL7* / cyclin B3*ENSMUSG0000005159226
Ccna2 / P51943 / Cyclin-A2 / P20248*ENSMUSG0000002771525
Ccne2 / Q9Z238 / G1/S-specific cyclin-E2 / O96020* / cyclin E2*ENSMUSG0000002821220
Ccne1 / Q61457 / G1/S-specific cyclin-E1 / P24864* / cyclin E1*ENSMUSG0000000206818
Ccno / P0C242 / Cyclin-O / P22674*ENSMUSG0000004241718
Ccnd3 / P30282 / G1/S-specific cyclin-D3 / P30281* / cyclin D3*ENSMUSG0000003416515
Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*ENSMUSG0000007034813
Ccnd2 / P30280 / G1/S-specific cyclin-D2 / P30279* / cyclin D2*ENSMUSG0000000018413


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0040007 growth IMP
 biological_processGO:0043029 T cell homeostasis IMP
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane IDA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
The role of GTSE1 in G2/M progression after G2 checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / complex / reaction
 ENSMUSG00000023908 Pkmyt1 / Q9ESG9 / Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase / Q99640* / protein kinase, membrane associated tyrosine/threonine 1*  / reaction
 ENSMUSG00000029202 Pds5a / PDS5 cohesin associated factor A / Q29RF7*  / reaction
 ENSMUSG00000022070 Bora / Q8BS90 / Protein aurora borealis / Q6PGQ7* / bora, aurora kinase A activator*  / reaction
 ENSMUSG00000034021 Pds5b / Q4VA53 / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA. / Q9NTI5* / PDS5 cohesin associated factor B*  / reaction
 ENSMUSG00000034290 Nek9 / Q8K1R7 / Serine/threonine-protein kinase Nek9 / Q8TD19* / NIMA related kinase 9*  / reaction
 ENSMUSG00000024791 Cdca5 / Q9CPY3 / Sororin / Q96FF9* / cell division cycle associated 5*  / reaction
 ENSMUSG00000041408 Wapl / Q65Z40 / WAPL cohesin release factor / Q7Z5K2*  / reaction
 ENSMUSG00000027330 Cdc25b / P30306 / M-phase inducer phosphatase 2 / P30305* / cell division cycle 25B*  / reaction






 

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