ENSMUSG00000041408


Mus musculus

Features
Gene ID: ENSMUSG00000041408
  
Biological name :Wapl
  
Synonyms : Q65Z40 / Wapl / WAPL cohesin release factor
  
Possible biological names infered from orthology : Q7Z5K2
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: B
Gene start: 34673928
Gene end: 34747983
  
Corresponding Affymetrix probe sets: 10414113 (MoGene1.0st)   1434778_at (Mouse Genome 430 2.0 Array)   1434835_at (Mouse Genome 430 2.0 Array)   1440951_x_at (Mouse Genome 430 2.0 Array)   1442426_at (Mouse Genome 430 2.0 Array)   1457320_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087481
Ensembl peptide - ENSMUSP00000130547
Ensembl peptide - ENSMUSP00000133779
Ensembl peptide - ENSMUSP00000040232
Ensembl peptide - ENSMUSP00000117282
NCBI entrez gene - 218914     See in Manteia.
MGI - MGI:2675859
RefSeq - XM_006518824
RefSeq - NM_001004436
RefSeq - NM_001301330
RefSeq Peptide - NP_001004436
RefSeq Peptide - NP_001288259
swissprot - Q65Z40
swissprot - B7ZP47
swissprot - G3UXQ2
swissprot - F6YCH1
Ensembl - ENSMUSG00000041408
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 waplaENSDARG00000044144Danio rerio
 waplbENSDARG00000029768Danio rerio
 WAPLENSGALG00000001907Gallus gallus
 WAPLENSG00000062650Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR012502  WAPL domain
 IPR016024  Armadillo-type fold
 IPR022771  Wings apart-like protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007064 mitotic sister chromatid cohesion IBA
 biological_processGO:0008156 negative regulation of DNA replication ISS
 biological_processGO:0009636 response to toxic substance IDA
 biological_processGO:0035562 negative regulation of chromatin binding ISS
 biological_processGO:0045132 meiotic chromosome segregation IBA
 biological_processGO:0045875 negative regulation of sister chromatid cohesion ISO
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051983 regulation of chromosome segregation IMP
 biological_processGO:0060623 regulation of chromosome condensation IMP
 biological_processGO:0071168 protein localization to chromatin ISS
 biological_processGO:0071922 regulation of cohesin loading ISS
 cellular_componentGO:0000785 chromatin ISO
 cellular_componentGO:0000795 synaptonemal complex IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0008278 cohesin complex ISS
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005488 binding IEA


Pathways (from Reactome)
Pathway description
Separation of Sister Chromatids
Establishment of Sister Chromatid Cohesion
Cohesin Loading onto Chromatin
Resolution of Sister Chromatid Cohesion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Wapltm1.1Jmpt/Wapltm1.2Jmpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac * SJL

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Wapltm1.1Jmpt/Wapltm1.2Jmpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac * SJL

Allelic Composition: Espl1tm1.1Kna/Espl1tm1.2Kna,Wapltm1.1Jmpt/Wapltm1.2Jmpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Wapltm1.1Jmpt/Wapltm1.2Jmpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac * SJL

 MP:0011705 absent fibroblast proliferation "failure of a fibroblast cell population to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Wapltm1.1Jmpt/Wapltm1.2Jmpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034021 Pds5b / Q4VA53 / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA. / Q9NTI5* / PDS5 cohesin associated factor B*  / reaction / complex
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction
 ENSMUSG00000024293 Esco1 / Q69Z69 / N-acetyltransferase ESCO1 / Q5FWF5* / establishment of sister chromatid cohesion N-acetyltransferase 1*  / reaction
 ENSMUSG00000024791 Cdca5 / Q9CPY3 / Sororin / Q96FF9* / cell division cycle associated 5*  / complex / reaction
 ENSMUSG00000022034 Esco2 / Q8CIB9 / N-acetyltransferase ESCO2 / Q56NI9* / establishment of sister chromatid cohesion N-acetyltransferase 2*  / reaction
 ENSMUSG00000022314 Rad21 / Q61550 / Double-strand-break repair / O60216* / RAD21 cohesin complex component*  / reaction
 ENSMUSG00000030867 Plk1 / Q07832 / polo like kinase 1 / P53350*  / reaction
 ENSMUSG00000032218 Ccnb2 / P30276 / G2/mitotic-specific cyclin-B2 / O95067* / cyclin B2*  / reaction
 ENSMUSG00000029202 Pds5a / PDS5 cohesin associated factor A / Q29RF7*  / reaction / complex
 ENSMUSG00000041431 Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*  / reaction
 ENSMUSG00000041408 Wapl / Q65Z40 / WAPL cohesin release factor / Q7Z5K2*  / reaction
 ENSMUSG00000022141 Nipbl / Q6KCD5 / Nipped-B-like protein / Q6KC79* / NIPBL, cohesin loading factor*  / complex / reaction
 ENSMUSG00000031858 Mau2 / Q9D2X5 / MAU2 chromatid cohesion factor homolog / Q9Y6X3* / MAU2 sister chromatid cohesion factor*  / reaction / complex






 

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