ENSMUSG00000022034


Mus musculus

Features
Gene ID: ENSMUSG00000022034
  
Biological name :Esco2
  
Synonyms : Esco2 / N-acetyltransferase ESCO2 / Q8CIB9
  
Possible biological names infered from orthology : establishment of sister chromatid cohesion N-acetyltransferase 2 / Q56NI9
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D1
Gene start: 65819038
Gene end: 65833994
  
Corresponding Affymetrix probe sets: 10420877 (MoGene1.0st)   1428304_at (Mouse Genome 430 2.0 Array)   1456311_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153210
Ensembl peptide - ENSMUSP00000022613
NCBI entrez gene - 71988     See in Manteia.
MGI - MGI:1919238
RefSeq - NM_028039
RefSeq Peptide - NP_082315
swissprot - A0A286YD00
swissprot - Q8CIB9
Ensembl - ENSMUSG00000022034
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 esco2ENSDARG00000014685Danio rerio
 ESCO2ENSGALG00000016583Gallus gallus
 ESCO2ENSG00000171320Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Esco1 / Q69Z69 / N-acetyltransferase ESCO1 / Q5FWF5* / establishment of sister chromatid cohesion N-acetyltransferase 1*ENSMUSG0000002429329


Protein motifs (from Interpro)
Interpro ID Name
 IPR028005  N-acetyltransferase ESCO, zinc-finger
 IPR028009  N-acetyltransferase ESCO, acetyl-transferase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IGI
 biological_processGO:0006275 regulation of DNA replication IEA
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0034421 post-translational protein acetylation IEA
 biological_processGO:0071168 protein localization to chromatin IMP
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0001741 XY body IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0010369 chromocenter IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031618 nuclear pericentric heterochromatin IDA
 cellular_componentGO:0035861 site of double-strand break IDA
 molecular_functionGO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IMP
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Establishment of Sister Chromatid Cohesion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: involves: 129S/SvEv * C57BL/6J * CAST/EiJ

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: involves: 129S/SvEv * C57BL/6J * CAST/EiJ

 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: involves: 129S/SvEv * C57BL/6J * CAST/EiJ

 MP:0000809 absent hippocampus "missing convoluted brain structure below the cerebral hemispheres; forms part of the limbic system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Esco2tm1.1Ge/Esco2tm1.1Ge
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: involves: 129S/SvEv * C57BL/6J * CAST/EiJ

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Esco2tm1.1Ge/Esco2tm1.1Ge
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: involves: 129S/SvEv * C57BL/6J * CAST/EiJ

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: involves: 129S/SvEv * C57BL/6J * CAST/EiJ

Allelic Composition: Esco2tm1.2Ge/Esco2tm1.2Ge
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N * SJL

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Esco2tm1.1Ge/Esco2tm1.1Ge
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0004760 increased mitotic index "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
Show

Allelic Composition: Col4a1deltaex40/Col4a1+
Genetic Background: involves: 129S/SvEv * C57BL/6J * CAST/EiJ

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Esco2tm1.1Ge/Esco2tm1.1Ge
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Esco2tm1.1Ge/Esco2tm1.1Ge
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Esco2tm1.2Ge/Esco2tm1.2Ge
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N * SJL

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Esco2tm1.2Ge/Esco2tm1.2Ge
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041408 Wapl / Q65Z40 / WAPL cohesin release factor / Q7Z5K2*  / reaction
 ENSMUSG00000034021 Pds5b / Q4VA53 / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA. / Q9NTI5* / PDS5 cohesin associated factor B*  / reaction
 ENSMUSG00000029202 Pds5a / PDS5 cohesin associated factor A / Q29RF7*  / reaction






 

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