ENSDARG00000014685


Danio rerio

Features
Gene ID: ENSDARG00000014685
  
Biological name :esco2
  
Synonyms : esco2 / establishment of sister chromatid cohesion N-acetyltransferase 2 / Q5SPR8
  
Possible biological names infered from orthology : N-acetyltransferase ESCO2 / Q56NI9 / Q8CIB9
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 39344889
Gene end: 39359154
  
Corresponding Affymetrix probe sets: Dr.3337.1.S1_at (Zebrafish Array)   NM_001003872_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000002535
NCBI entrez gene - 445395     See in Manteia.
RefSeq - XM_005160818
RefSeq - NM_001003872
RefSeq Peptide - NP_001003872
swissprot - Q5SPR8
ZFIN ID - ZDB-GENE-050913-156
Ensembl - ENSDARG00000014685
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ESCO2ENSGALG00000016583Gallus gallus
 ESCO2ENSG00000171320Homo sapiens
 Esco2ENSMUSG00000022034Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
esco1 / establishment of sister chromatid cohesion N-acetyltransferase 1 / Q5FWF5* / Q69Z69* / N-acetyltransferase ESCO1 *ENSDARG0000007705726


Protein motifs (from Interpro)
Interpro ID Name
 IPR028005  N-acetyltransferase ESCO, zinc-finger
 IPR028009  N-acetyltransferase ESCO, acetyl-transferase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0006275 regulation of DNA replication ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:1990523 bone regeneration IMP
 cellular_componentGO:0000785 chromatin ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Establishment of Sister Chromatid Cohesion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
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 ZFA:0000009 cardiac ventricle cardiac ventricle decreased size , abnormal
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 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000029 hindbrain hindbrain lacks all parts of type radial glial cell , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary quality , abnormal
midbrain hindbrain boundary condensed , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000059 postoptic commissure postoptic commissure morphology , abnormal
postoptic commissure defasciculated , abnormal
postoptic commissure astrocyte mislocalised , abnormal
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 ZFA:0000075 spinal cord spinal cord has extra parts of type ventricular zone radial glial cell, abnormal
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 ZFA:0000084 yolk yolk quality , abnormal
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 ZFA:0000106 extension extension decreased thickness , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye hypoplastic , abnormal
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 ZFA:0000109 forebrain forebrain commissural neuron axon guidance disrupted , abnormal
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 ZFA:0000112 gut gut quality , abnormal
gut hypoplastic , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0000155 somite somite disorganized , abnormal
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 ZFA:0000368 integument integument decreased pigmentation , abnormal
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 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0000435 cranial nerve II cranial nerve II decreased size , abnormal
cranial nerve II decreased thickness , abnormal
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 ZFA:0000890 floor plate spinal cord region floor plate spinal cord region glial cell (sensu Vertebrata) increased size , abnormal
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 ZFA:0001058 caudal fin caudal fin curved , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
whole organism shortened , abnormal
whole organism shape , abnormal
whole organism viability , abnormal
whole organism necrotic , abnormal
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 ZFA:0001108 anterior commissure anterior commissure morphology , abnormal
anterior commissure defasciculated , abnormal
anterior commissure astrocyte mislocalised , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head hypoplastic , abnormal
head flat , abnormal
head necrotic , abnormal
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 ZFA:0001115 trunk trunk decreased thickness , abnormal
trunk necrotic , abnormal
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 ZFA:0001117 post-vent region post-vent region curved dorsal , abnormal
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 ZFA:0001135 neural tube neural tube apoptotic process increased process quality , abnormal
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 ZFA:0001161 pectoral fin pectoral fin cell decreased size , abnormal
pectoral fin cell condensed , abnormal
pectoral fin decreased length , abnormal
pectoral fin deformed , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton aplastic , abnormal
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 ZFA:0001269 regenerating fin regenerating fin decreased length , abnormal
regenerating fin decreased amount , abnormal
regenerating fin cell proliferation decreased occurrence , abnormal
regenerating fin length , ameliorated
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 ZFA:0001439 anatomical system anatomical system quality , abnormal
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 ZFA:0001510 basihyal cartilage basihyal cartilage deformed , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage decreased length , abnormal
ceratobranchial cartilage decreased size , abnormal
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 ZFA:0001522 hypobranchial cartilage hypobranchial cartilage decreased thickness , abnormal
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 ZFA:0001655 pericardial cavity pericardial cavity edematous , abnormal
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 ZFA:0009000 cell cell chromosome disorganized , abnormal
cell mitotic spindle deformed , abnormal
cell chromosome amount , abnormal
cell chromosome separated from cell chromosome, abnormal
cell chromosome distributed , abnormal
cell micronucleus increased amount , abnormal
cell metaphase plate absent , abnormal
cell mitotic spindle rotated , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000098897 pds5b / PDS5 cohesin associated factor B / Q4VA53* / Q9NTI5* / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA.*  / reaction
 ENSDARG00000044144 wapla / WAPL cohesin release factor a / WAPL* / Q7Z5K2* / Q65Z40* / WAPL cohesin release factor*  / reaction
 ENSDARG00000055022 pds5a / PDS5 cohesin associated factor A / Q29RF7*  / reaction






 

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