Manteia - Molecule gene

ENSMUSG00000029202

Mus musculus

Features

Gene ID:	ENSMUSG00000029202

Biological name :	Pds5a

Synonyms :	Pds5a / PDS5 cohesin associated factor A

Possible biological names infered from orthology :	Q29RF7

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	C3.1
Gene start:	65605721
Gene end:	65698273

Corresponding Affymetrix probe sets:	10530225 (MoGene1.0st) 1425082_s_at (Mouse Genome 430 2.0 Array) 1434215_at (Mouse Genome 430 2.0 Array) 1441238_at (Mouse Genome 430 2.0 Array) 1442731_at (Mouse Genome 430 2.0 Array) 1454872_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000144171 Ensembl peptide - ENSMUSP00000144463 Ensembl peptide - ENSMUSP00000031104 NCBI entrez gene - 71521 See in Manteia. MGI - MGI:1918771 RefSeq - XM_006504115 RefSeq - XM_006504118 RefSeq - NM_001081321 RefSeq - XM_006504117 RefSeq Peptide - NP_001074790 swissprot - E9QPI5 swissprot - A0A0J9YV33 Ensembl - ENSMUSG00000029202

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
pds5a	ENSDARG00000055022	Danio rerio
PDS5A	ENSGALG00000014286	Gallus gallus
PDS5A	ENSG00000121892	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Pds5b / Q4VA53 / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA. / Q9NTI5* / PDS5 cohesin associated factor B*	ENSMUSG00000034021	69

Protein motifs (from Interpro)

Interpro ID	Name
IPR011989	Armadillo-like helical
IPR016024	Armadillo-type fold

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007064	mitotic sister chromatid cohesion	IEA
biological_process	GO:0008156	negative regulation of DNA replication	IEA
cellular_component	GO:0000785	chromatin	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005886	plasma membrane	IEA
molecular_function	GO:0005488	binding	IEA

Pathways (from Reactome)

Pathway description

Separation of Sister Chromatids

Establishment of Sister Chromatid Cohesion

Cohesin Loading onto Chromatin

Resolution of Sister Chromatid Cohesion

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0000150	abnormal rib morphology	"malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0000157	abnormal sternum morphology	"malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺,Pds5b^tm1Jmi/Pds5b^tm1Jmi Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000281	abnormal ventricular septum morphology	"abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺,Pds5b^tm1Jmi/Pds5b^tm1Jmi Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0000298	absent endocardial cushion	"absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺,Pds5b^tm1Jmi/Pds5b^tm1Jmi Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000379	reduced hair follicle number	"fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]	Show Allelic Composition: Nras^tm1Tyj/Nras^tm1Tyj,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0000520	absent kidney	"missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0001044	abnormal enteric nervous system morphology	"malformation or absence of the part of the autonomic nervous system that innervates the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺,Pds5b^tm1Jmi/Pds5b^tm1Jmi Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001286	abnormal eye development	"malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001306	small lens	"reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺,Pds5b^tm1Jmi/Pds5b^tm1Jmi Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001780	decreased brown fat amount	"reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nras^tm1Tyj/Nras^tm1Tyj,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0002060	abnormal skin morphology	"malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]	Show Allelic Composition: Nras^tm1Tyj/Nras^tm1Tyj,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0002633	persistent truncus arteriosis	"complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003078	aphakia	"absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺,Pds5b^tm1Jmi/Pds5b^tm1Jmi Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003140	dilated atria	"an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺,Pds5b^tm1Jmi/Pds5b^tm1Jmi Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003419	delayed endochondral bone ossification	"late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Nras^tm1Tyj/Nras^tm1Tyj,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0003425	abnormal optic vesicle formation	"anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003446	renal hypoplasia	"decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0003604	single kidney		Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0003632	abnormal nervous system morphology		Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺,Pds5b^tm1Jmi/Pds5b^tm1Jmi Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺,Pds5b^tm1Jmi/Pds5b^tm1Jmi Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004046	abnormal mitosis	"anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nras^tm1Tyj/Nras^tm1Tyj,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0004200	reduced fetal size	"smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nras^tm1Tyj/Nras^tm1Tyj,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0004201	fetal growth retardation	"slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nras^tm1Tyj/Nras^tm1Tyj,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0004505	decreased renal glomerulus number	"reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0004607	abnormal cervical atlas morphology	"any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0004615	cervical vertebral transformation	"homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0004620	cervical vertebral fusion	"the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0005545	abnormal lens development	"aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008148	abnormal rib-sternum attachment	"any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0008276	failure of intramembranous bone ossification	"failure to initiate or a block in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957]	Show Allelic Composition: Nras^tm1Tyj/Nras^tm1Tyj,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0009267	abnormal cerebellum fissure morphology	"any structural anomaly of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Nras^tm1Tyj/Nras^tm1Tyj,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0009674	decreased birth weight	"reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0009703	decreased birth body size	"reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0009888	palatal shelves fail to meet at midline	"polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
MP:0010403	atrial septal defect	"abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
MP:0010412	atrioventricular septal defect	"defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0010413	complete atrioventricular septal defect	"a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺,Pds5b^tm1Jmi/Pds5b^tm1Jmi Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0010418	perimembraneous ventricular septal defect	"abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0010556	thin ventricle myocardium compact layer	"reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺,Pds5b^tm1Jmi/Pds5b^tm1Jmi Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0010587	conotruncal ridge hypoplasia	"underdevelopment or reduced size of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺,Pds5b^tm1Jmi/Pds5b^tm1Jmi Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0010589	common truncal valve	"a single outflow tract valve that opens into the truncus arteriosus that is frequently present in cases of truncus arteriosus septation defects" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺,Pds5b^tm1Jmi/Pds5b^tm1Jmi Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0010607	common atrioventricular valve	"the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺,Pds5b^tm1Jmi/Pds5b^tm1Jmi Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0010652	absent aorticopulmonary septum	"absence of the spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺,Pds5b^tm1Jmi/Pds5b^tm1Jmi Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr Genetic Background: C57BL/6J-Tfr2^m1Btlr
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a⁺,Pds5b^tm1Jmi/Pds5b^tm1Jmi Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg},Pds5b^tm1Jmi/Pds5b⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Nras^tm1Tyj/Nras^tm1Tyj,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000034021	Pds5b / Q4VA53 / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA. / Q9NTI5* / PDS5 cohesin associated factor B*	/ reaction
ENSMUSG00000019942	Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*	/ reaction
ENSMUSG00000024293	Esco1 / Q69Z69 / N-acetyltransferase ESCO1 / Q5FWF5* / establishment of sister chromatid cohesion N-acetyltransferase 1*	/ reaction
ENSMUSG00000024791	Cdca5 / Q9CPY3 / Sororin / Q96FF9* / cell division cycle associated 5*	/ complex / reaction
ENSMUSG00000022034	Esco2 / Q8CIB9 / N-acetyltransferase ESCO2 / Q56NI9* / establishment of sister chromatid cohesion N-acetyltransferase 2*	/ reaction
ENSMUSG00000022314	Rad21 / Q61550 / Double-strand-break repair / O60216* / RAD21 cohesin complex component*	/ reaction
ENSMUSG00000030867	Plk1 / Q07832 / polo like kinase 1 / P53350*	/ reaction
ENSMUSG00000032218	Ccnb2 / P30276 / G2/mitotic-specific cyclin-B2 / O95067* / cyclin B2*	/ reaction
ENSMUSG00000041408	Wapl / Q65Z40 / WAPL cohesin release factor / Q7Z5K2*	/ complex / reaction
ENSMUSG00000029202	Pds5a / PDS5 cohesin associated factor A / Q29RF7*	/ reaction
ENSMUSG00000041431	Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*	/ reaction
ENSMUSG00000022141	Nipbl / Q6KCD5 / Nipped-B-like protein / Q6KC79* / NIPBL, cohesin loading factor*	/ reaction / complex
ENSMUSG00000031858	Mau2 / Q9D2X5 / MAU2 chromatid cohesion factor homolog / Q9Y6X3* / MAU2 sister chromatid cohesion factor*	/ complex / reaction

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