ENSMUSG00000022314


Mus musculus

Features
Gene ID: ENSMUSG00000022314
  
Biological name :Rad21
  
Synonyms : Double-strand-break repair / Q61550 / Rad21
  
Possible biological names infered from orthology : O60216 / RAD21 cohesin complex component
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: C
Gene start: 51962240
Gene end: 51991747
  
Corresponding Affymetrix probe sets: 10428561 (MoGene1.0st)   1416161_at (Mouse Genome 430 2.0 Array)   1416162_at (Mouse Genome 430 2.0 Array)   1455938_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022927
Ensembl peptide - ENSMUSP00000154815
NCBI entrez gene - 19357     See in Manteia.
MGI - MGI:108016
RefSeq - XM_006520645
RefSeq - NM_009009
RefSeq - XM_006520644
RefSeq Peptide - NP_033035
swissprot - Q61550
Ensembl - ENSMUSG00000022314
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad21aENSDARG00000006092Danio rerio
 rad21bENSDARG00000035655Danio rerio
 RAD21ENSGALG00000029523Gallus gallus
 RAD21ENSG00000164754Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rad21l / A2AU37 / Double-strand-break repair protein rad21-like protein 1 / Q9H4I0* / RAD21L1* / RAD21 cohesin complex component like 1*ENSMUSG0000007470439


Protein motifs (from Interpro)
Interpro ID Name
 IPR006909  Rad21/Rec8-like protein, C-terminal, eukaryotic
 IPR006910  Rad21/Rec8-like protein, N-terminal
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IBA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007062 sister chromatid cohesion IBA
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0045841 negative regulation of mitotic metaphase/anaphase transition IMP
 biological_processGO:0045876 positive regulation of sister chromatid cohesion IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0071168 protein localization to chromatin IEA
 cellular_componentGO:0000228 nuclear chromosome IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0000798 nuclear cohesin complex IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0008278 cohesin complex IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IDA


Pathways (from Reactome)
Pathway description
Separation of Sister Chromatids
Establishment of Sister Chromatid Cohesion
Cohesin Loading onto Chromatin
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA damage response and repair proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Rec8tm1.1Kktk/Rec8tm1.1Kktk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1ctm5.1Hfm/Cacna1ctm5.1Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacna1ctm5.1Hfm/Cacna1ctm5.1Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cacna1ctm5.1Hfm/Cacna1ctm5.1Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rec8tm1.1Kktk/Rec8tm1.1Kktk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cacna1ctm5.1Hfm/Cacna1ctm5.1Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1ctm5.1Hfm/Cacna1ctm5.1Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1ctm5.1Hfm/Cacna1ctm5.1Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Rec8tm1.1Kktk/Rec8tm1.1Kktk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Rad21tm2.1Kktk/Rad21tm2.1Kktk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034021 Pds5b / Q4VA53 / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA. / Q9NTI5* / PDS5 cohesin associated factor B*  / reaction
 ENSMUSG00000029202 Pds5a / PDS5 cohesin associated factor A / Q29RF7*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex
 ENSMUSG00000041408 Wapl / Q65Z40 / WAPL cohesin release factor / Q7Z5K2*  / reaction






 

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