ENSMUSG00000074704


Mus musculus

Features
Gene ID: ENSMUSG00000074704
  
Biological name :Rad21l
  
Synonyms : A2AU37 / Double-strand-break repair protein rad21-like protein 1 / Rad21l
  
Possible biological names infered from orthology : Q9H4I0 / RAD21 cohesin complex component like 1 / RAD21L1
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: G3
Gene start: 151645404
Gene end: 151668533
  
Corresponding Affymetrix probe sets: 10488565 (MoGene1.0st)   10488567 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000094174
Ensembl peptide - ENSMUSP00000136918
NCBI entrez gene - 668929     See in Manteia.
MGI - MGI:3652039
RefSeq - XM_006500044
RefSeq - NM_001276400
RefSeq - XM_006500042
RefSeq - XM_006500043
RefSeq Peptide - NP_001263329
swissprot - A2AU37
swissprot - R4GML2
Ensembl - ENSMUSG00000074704
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAD21L1ENSGALG00000006186Gallus gallus
 Q9H4I0ENSG00000244588Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rad21 / Q61550 / Double-strand-break repair / O60216* / RAD21 cohesin complex component*ENSMUSG0000002231444


Protein motifs (from Interpro)
Interpro ID Name
 IPR006909  Rad21/Rec8-like protein, C-terminal, eukaryotic
 IPR006910  Rad21/Rec8-like protein, N-terminal
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IGI
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007062 sister chromatid cohesion IBA
 biological_processGO:0007129 synapsis IMP
 biological_processGO:0007130 synaptonemal complex assembly IGI
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0070197 meiotic attachment of telomere to nuclear envelope IMP
 biological_processGO:0072520 seminiferous tubule development IGI
 cellular_componentGO:0000228 nuclear chromosome IEA
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0000800 lateral element IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0030893 meiotic cohesin complex IDA
 cellular_componentGO:0034991 nuclear meiotic cohesin complex IDA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Rad21ltm1b(KOMP)Wtsi/Rad21ltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad21ltm1b(KOMP)Wtsi/J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001930 abnormal meiosis "malfunction in the process of nuclear division that results in gametes with one half the normal number of the original cell" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sun1tm1Mhan/Sun1tm1Mhan
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow,Rec8mei8/Rec8mei8
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rad21ltm1b(KOMP)Wtsi/Rad21ltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad21ltm1b(KOMP)Wtsi/J

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0004833 ovary atrophy "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rad21ltm1Amp/Rad21ltm1Amp
Genetic Background: B6.Cg-Rad21ltm1Amp

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow,Rec8mei8/Rec8mei8
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow,Sun1tm1Mhan/Sun1tm1Mhan
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rad21ltm1b(KOMP)Wtsi/Rad21ltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad21ltm1b(KOMP)Wtsi/J

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

 MP:0009451 abnormal chromosome pairing during meiosis "an anomaly in the highly specific side-by-side association of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow,Sun1tm1Mhan/Sun1tm1Mhan
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0009452 abnormal synaptonemal complex "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0010207 abnormal telomere morphology "any structural anomaly of the terminal repetitive DNA section of a chromosome which is involved in chromosomal replication and senescence, and which protects the end of the chromosome from deterioration" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

 MP:0011122 absent primordial ovarian follicles "absence of the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:csmith]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

 MP:0013607 ovary fibrosis "invasion of fibrous connective tissue into the ovary, often resulting from inflammation or injury" [MGI:Anna]
Show

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr