ENSDARG00000006092


Danio rerio

Features
Gene ID: ENSDARG00000006092
  
Biological name :rad21a
  
Synonyms : rad21a / RAD21 cohesin complex component a
  
Possible biological names infered from orthology : Double-strand-break repair / O60216 / Q61550 / RAD21 / RAD21 cohesin complex component
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 48409066
Gene end: 48430272
  
Corresponding Affymetrix probe sets: Dr.5662.1.S1_at (Zebrafish Array)   NM_199595_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000009867
Ensembl peptide - ENSDARP00000156767
NCBI entrez gene - 322275     See in Manteia.
RefSeq - NM_199595
RefSeq Peptide - NP_955889
swissprot - Q6TEL1
ZFIN ID - ZDB-GENE-030131-994
Ensembl - ENSDARG00000006092
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAD21ENSGALG00000029523Gallus gallus
 RAD21ENSG00000164754Homo sapiens
 Rad21ENSMUSG00000022314Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rad21b / RAD21 cohesin complex component b / RAD21* / Q61550* / O60216* / Double-strand-break repair * / RAD21 cohesin complex component*ENSDARG0000003565581
rad21l1 / RAD21 cohesin complex component like 1ENSDARG0000002249334


Protein motifs (from Interpro)
Interpro ID Name
 IPR006909  Rad21/Rec8-like protein, C-terminal, eukaryotic
 IPR006910  Rad21/Rec8-like protein, N-terminal
 IPR011991  ArsR-like helix-turn-helix domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003181 atrioventricular valve morphogenesis IMP
 biological_processGO:0003187 ventriculo bulbo valve morphogenesis IMP
 biological_processGO:0006302 double-strand break repair IBA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006412 translation IMP
 biological_processGO:0007064 mitotic sister chromatid cohesion IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008015 blood circulation IMP
 biological_processGO:0009303 rRNA transcription IMP
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0048484 enteric nervous system development IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0060037 pharyngeal system development IMP
 cellular_componentGO:0000228 nuclear chromosome IEA
 cellular_componentGO:0000798 nuclear cohesin complex IBA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
Separation of Sister Chromatids
Establishment of Sister Chromatid Cohesion
Cohesin Loading onto Chromatin
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA damage response and repair proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain necrotic , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle blood decreased amount , abnormal
Show

 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000105 epidermis epidermis melanocyte position , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye decreased size , ameliorated
Show

 ZFA:0000112 gut gut peristalsis decreased process quality , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
heart cardiac neural crest decreased amount , abnormal
heart edematous , abnormal
heart malformed , abnormal
heart morphology , abnormal
Show

 ZFA:0000295 trigeminal ganglion trigeminal ganglion decreased size , abnormal
Show

 ZFA:0000471 atrium atrium blood decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism apoptotic , abnormal
whole organism decreased amount , abnormal
whole organism viability , abnormal
whole organism morphology , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism chromosome disorganized , abnormal
whole organism chromosome condensed , abnormal
whole organism deformed , abnormal
whole organism increased amount , abnormal
whole organism lethal (sensu genetics) , ameliorated
whole organism decreased size , abnormal
whole organism dead , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
head decreased size , ameliorated
head apoptotic process increased occurrence , abnormal
head apoptotic process increased occurrence , ameliorated
Show

 ZFA:0001115 trunk trunk decreased length , ameliorated
trunk decreased thickness , abnormal
trunk degenerate , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved , abnormal
post-vent region curved , ameliorated
post-vent region apoptotic process increased occurrence , abnormal
post-vent region apoptotic process increased occurrence , ameliorated
Show

 ZFA:0001135 neural tube neural tube pigmentation increased occurrence , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch morphology , abnormal
pharyngeal arch disorganized , abnormal
pharyngeal arch aplastic , abnormal
Show

 ZFA:0001375 ventriculo bulbo valve ventriculo bulbo valve decreased size , abnormal
ventriculo bulbo valve aplastic , abnormal
Show

 ZFA:0001458 cranial cartilage cranial cartilage cartilage development disrupted , abnormal
cranial cartilage cartilage development decreased process quality , ameliorated
Show

 ZFA:0001648 cardiac neural crest cardiac neural crest mislocalised , abnormal
cardiac neural crest accumulation otic vesicle posterior region, abnormal
Show

 ZFA:0005064 atrioventricular valve atrioventricular valve orientation ventriculo bulbo valve , abnormal
atrioventricular valve decreased size , abnormal
atrioventricular valve non-functional , abnormal
Show

 ZFA:0005775 enteric neuron enteric neuron decreased amount , abnormal
Show

 ZFA:0009000 cell cell spindle morphology , abnormal
Show

 ZFA:0009091 melanocyte melanocyte mislocalised , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron decreased amount , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte increased accumulation heart , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr