ENSMUSG00000034021


Mus musculus

Features
Gene ID: ENSMUSG00000034021
  
Biological name :Pds5b
  
Synonyms : Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA. / Pds5b / Q4VA53
  
Possible biological names infered from orthology : PDS5 cohesin associated factor B / Q9NTI5
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G3
Gene start: 150673739
Gene end: 150810690
  
Corresponding Affymetrix probe sets: 10527832 (MoGene1.0st)   1435242_at (Mouse Genome 430 2.0 Array)   1436161_at (Mouse Genome 430 2.0 Array)   1441553_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016569
Ensembl peptide - ENSMUSP00000038421
Ensembl peptide - ENSMUSP00000106112
Ensembl peptide - ENSMUSP00000144572
NCBI entrez gene - 100710     See in Manteia.
MGI - MGI:2140945
RefSeq - XM_006504905
RefSeq - NM_001346503
RefSeq - NM_175310
RefSeq - XM_006504901
RefSeq - XM_006504902
RefSeq - XM_006504903
RefSeq - XM_006504904
RefSeq Peptide - NP_001333432
RefSeq Peptide - NP_780519
swissprot - Q4VA53
swissprot - F8WHU5
Ensembl - ENSMUSG00000034021
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pds5bENSDARG00000098897Danio rerio
 PDS5BENSGALG00000017070Gallus gallus
 PDS5BENSG00000083642Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pds5a / PDS5 cohesin associated factor A / Q29RF7*ENSMUSG0000002920263


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007064 mitotic sister chromatid cohesion ISO
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0042127 regulation of cell proliferation ISO
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000785 chromatin IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm ISO
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005488 binding IEA


Pathways (from Reactome)
Pathway description
Separation of Sister Chromatids
Establishment of Sister Chromatid Cohesion
Cohesin Loading onto Chromatin
Resolution of Sister Chromatid Cohesion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+,Pds5btm1Jmi/Pds5btm1Jmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+,Pds5btm1Jmi/Pds5btm1Jmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000298 absent endocardial cushion "absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS]
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+,Pds5btm1Jmi/Pds5btm1Jmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001044 abnormal enteric nervous system morphology "malformation or absence of the part of the autonomic nervous system that innervates the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+,Pds5btm1Jmi/Pds5btm1Jmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+,Pds5btm1Jmi/Pds5btm1Jmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sgcbtm1Oza/Sgcbtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003056 abnormal hyoid bone "anomalous structure of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0003078 aphakia "absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+,Pds5btm1Jmi/Pds5btm1Jmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+,Pds5btm1Jmi/Pds5btm1Jmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0003425 abnormal optic vesicle formation "anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+,Pds5btm1Jmi/Pds5btm1Jmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+,Pds5btm1Jmi/Pds5btm1Jmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0004340 short scapula "reduced length of either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0008312 abnormal sympathetic postganglionic fiber "any structural anomaly of any or all of the noradrenergic and some adrenergic axonal fibers projecting from a sympathetic ganglion to an effector organ" [MESH:A08.663.542.075.800, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0009887 abnormal palatal shelf fusion at midline "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0009891 abnormal palate bone morphology "any structural anomaly of the maxillary or palatine shelves that comprise the bones of the hard palate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0010405 ostium secundum atrial septal defect "large interatrial communication (atrial septal defect) through the center of the wall between the atria at the site of the foramen ovale and the ostium secundum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0010413 complete atrioventricular septal defect "a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+,Pds5btm1Jmi/Pds5btm1Jmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0010556 thin ventricle myocardium compact layer "reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+,Pds5btm1Jmi/Pds5btm1Jmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010587 conotruncal ridge hypoplasia "underdevelopment or reduced size of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+,Pds5btm1Jmi/Pds5btm1Jmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010589 common truncal valve "a single outflow tract valve that opens into the truncus arteriosus that is frequently present in cases of truncus arteriosus septation defects" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+,Pds5btm1Jmi/Pds5btm1Jmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010607 common atrioventricular valve "the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+,Pds5btm1Jmi/Pds5btm1Jmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010652 absent aorticopulmonary septum "absence of the spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+,Pds5btm1Jmi/Pds5btm1Jmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5a+,Pds5btm1Jmi/Pds5btm1Jmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg,Pds5btm1Jmi/Pds5b+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0030168 thin upper lip "upper lips having a reduced amount of soft tissue" [MGI:anna]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0030243 abnormal chin morphology "any structural anomaly of the inferior portion of the face lying inferior to the lower lip and including the central prominence of the lower jaw" [https://elementsofmorphology.nih.gov/anatomy-head_face.shtml, MGI:anna]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0030244 short chin "decreased vertical dimension of the inferior portion of the face lying inferior to the lower lip and including the central prominence of the lower jaw" [https://elementsofmorphology.nih.gov/anatomy-head_face.shtml, MGI:anna]
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Allelic Composition: Trps1tm1.1Shiv/Trps1+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034021 Pds5b / Q4VA53 / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA. / Q9NTI5* / PDS5 cohesin associated factor B*  / reaction
 ENSMUSG00000029202 Pds5a / PDS5 cohesin associated factor A / Q29RF7*  / reaction
 ENSMUSG00000041408 Wapl / Q65Z40 / WAPL cohesin release factor / Q7Z5K2*  / complex / reaction
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction
 ENSMUSG00000024293 Esco1 / Q69Z69 / N-acetyltransferase ESCO1 / Q5FWF5* / establishment of sister chromatid cohesion N-acetyltransferase 1*  / reaction
 ENSMUSG00000024791 Cdca5 / Q9CPY3 / Sororin / Q96FF9* / cell division cycle associated 5*  / reaction / complex
 ENSMUSG00000022034 Esco2 / Q8CIB9 / N-acetyltransferase ESCO2 / Q56NI9* / establishment of sister chromatid cohesion N-acetyltransferase 2*  / reaction
 ENSMUSG00000022314 Rad21 / Q61550 / Double-strand-break repair / O60216* / RAD21 cohesin complex component*  / reaction
 ENSMUSG00000030867 Plk1 / Q07832 / polo like kinase 1 / P53350*  / reaction
 ENSMUSG00000032218 Ccnb2 / P30276 / G2/mitotic-specific cyclin-B2 / O95067* / cyclin B2*  / reaction
 ENSMUSG00000041431 Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*  / reaction
 ENSMUSG00000022141 Nipbl / Q6KCD5 / Nipped-B-like protein / Q6KC79* / NIPBL, cohesin loading factor*  / complex / reaction
 ENSMUSG00000031858 Mau2 / Q9D2X5 / MAU2 chromatid cohesion factor homolog / Q9Y6X3* / MAU2 sister chromatid cohesion factor*  / complex / reaction






 

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