ENSMUSG00000030867


Mus musculus

Features
Gene ID: ENSMUSG00000030867
  
Biological name :Plk1
  
Synonyms : Plk1 / polo like kinase 1 / Q07832
  
Possible biological names infered from orthology : P53350
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F2
Gene start: 122159439
Gene end: 122169873
  
Corresponding Affymetrix probe sets: 10557156 (MoGene1.0st)   1448191_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033154
Ensembl peptide - ENSMUSP00000146253
Ensembl peptide - ENSMUSP00000145631
NCBI entrez gene - 18817     See in Manteia.
MGI - MGI:97621
RefSeq - NM_011121
RefSeq Peptide - NP_035251
swissprot - A0A0U1RNM9
swissprot - A0A0U1RQ54
swissprot - Q07832
swissprot - Q3TPZ2
Ensembl - ENSMUSG00000030867
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plk1ENSDARG00000058471Danio rerio
 PLK1ENSGALG00000006110Gallus gallus
 PLK1ENSG00000166851Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plk3 / serine/threonine-protein kinase PLK3 isoform 2 / Q9H4B4* / polo like kinase 3*ENSMUSG0000002868039
Plk2 / P53351 / Serine/threonine-protein kinase PLK2 / Q9NYY3* / polo like kinase 2*ENSMUSG0000002170139
Plk5 / Q4FZD7 / Mus musculus polo like kinase 5 (Plk5), transcript variant 2, mRNA. / Q496M5* / polo like kinase 5*ENSMUSG0000003548633
Plk4 / Q64702 / Serine/threonine-protein kinase PLK4 / O00444* / polo like kinase 4*ENSMUSG0000002575823


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000959  POLO box domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033695  Second polo-box domain
 IPR033701  First polo-box domain
 IPR033702  Polo-like kinase 1, catalytic domain
 IPR036947  POLO box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IEA
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0001578 microtubule bundle formation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007094 mitotic spindle assembly checkpoint IEA
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016321 female meiosis chromosome segregation IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0030071 regulation of mitotic metaphase/anaphase transition IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043393 regulation of protein binding IEA
 biological_processGO:0045143 homologous chromosome segregation IMP
 biological_processGO:0045184 establishment of protein localization IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045862 positive regulation of proteolysis IEA
 biological_processGO:0051081 nuclear envelope disassembly IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IEA
 biological_processGO:0070194 synaptonemal complex disassembly IMP
 biological_processGO:0071168 protein localization to chromatin IEA
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint IEA
 biological_processGO:0090435 protein localization to nuclear envelope IEA
 biological_processGO:1901673 regulation of mitotic spindle assembly IEA
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IDA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0000795 synaptonemal complex IDA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0000942 condensed nuclear chromosome outer kinetochore IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005876 spindle microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0051233 spindle midzone IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0010997 anaphase-promoting complex binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase
Mitotic Metaphase/Anaphase Transition
Mitotic Telophase/Cytokinesis
Cyclin A/B1/B2 associated events during G2/M transition
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Il15ratm1Wjl/Il15ratm1Wjl
Genetic Background: involves: 129 * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Il15ratm1Wjl/Il15ratm1Wjl
Genetic Background: involves: 129 * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Il15ratm1Wjl/Il15ratm1Wjl
Genetic Background: involves: 129 * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Il15ratm1Wjl/Il15ratm1Wjl
Genetic Background: involves: 129 * C57BL/6

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Il15ratm1Wjl/Il15ratm1Wjl
Genetic Background: involves: 129 * C57BL/6

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il15ratm1Wjl/Il15ratm1Wjl
Genetic Background: involves: 129 * C57BL/6

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il15ratm1Wjl/Il15ratm1Wjl
Genetic Background: involves: 129 * C57BL/6

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Il15ratm1Wjl/Il15ratm1Wjl
Genetic Background: involves: 129 * C57BL/6

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Il15ratm1Wjl/Il15ratm1Wjl
Genetic Background: involves: 129 * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Il15ratm1Wjl/Il15ratm1Wjl
Genetic Background: involves: 129 * C57BL/6

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014956 P62141 / Ppp1cb / Serine/threonine-protein phosphatase PP1-beta catalytic subunit / P62140* / protein phosphatase 1 catalytic subunit beta*  / reaction
 ENSMUSG00000020149 Rab1 / P62821 / Ras-related protein Rab-1A / RAB1A* / P62820* / RAB1A, member RAS oncogene family*  / complex
 ENSMUSG00000020235 Fzr1 / Q9R1K5 / Fizzy-related protein homolog / Q9UM11* / fizzy and cell division cycle 20 related 1*  / reaction
 ENSMUSG00000022385 Gtse1 / Q8R080 / G2 and S phase-expressed protein 1 / Q9NYZ3* / G2 and S-phase expressed 1*  / reaction / complex
 ENSMUSG00000028851 Nudc / O35685 / Nuclear migration protein nudC / Q9Y266* / nuclear distribution C, dynein complex regulator*  / reaction
 ENSMUSG00000027496 Aurka / P97477 / Aurora kinase A / O14965*  / reaction / complex
 ENSMUSG00000022070 Bora / Q8BS90 / Protein aurora borealis / Q6PGQ7* / bora, aurora kinase A activator*  / complex / reaction
 ENSMUSG00000019773 Fbxo5 / Q7TSG3 / F-box only protein 5 / Q9UKT4* / F-box protein 5*  / reaction
 ENSMUSG00000023908 Pkmyt1 / Q9ESG9 / Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase / Q99640* / protein kinase, membrane associated tyrosine/threonine 1*  / reaction
 ENSMUSG00000002546 Golga2 / Q921M4 / golgi autoantigen, golgin subfamily a, 2 / A7E2F4* / A8MQT2* / D6RF30* / F8WBI6* / A6NCC3* / A6NDK9* / A6NDN3* / A6NMD2* / H3BSY2* / I6L899* / P0CG33* / P0CJ92* / Q08379* ...  / complex
 ENSMUSG00000034021 Pds5b / Q4VA53 / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA. / Q9NTI5* / PDS5 cohesin associated factor B*  / reaction
 ENSMUSG00000026672 Optn / Q8K3K8 / Mus musculus optineurin (Optn), transcript variant 1, mRNA. / Q96CV9* / optineurin*  / reaction
 ENSMUSG00000029202 Pds5a / PDS5 cohesin associated factor A / Q29RF7*  / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000003779 Kif20a / P97329 / Kinesin-like protein KIF20A / O95235* / kinesin family member 20A*  / reaction
 ENSMUSG00000044201 Cdc25c / P48967 / cell division cycle 25C / P30307*  / reaction
 ENSMUSG00000001517 Foxm1 / forkhead box M1 / Q08050*  / complex / reaction
 ENSMUSG00000034290 Nek9 / Q8K1R7 / Serine/threonine-protein kinase Nek9 / Q8TD19* / NIMA related kinase 9*  / reaction
 ENSMUSG00000003037 Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*  / reaction
 ENSMUSG00000032513 Q91X51 / Gorasp1 / golgi reassembly stacking protein 1 / Q9BQQ3*  / complex
 ENSMUSG00000024791 Cdca5 / Q9CPY3 / Sororin / Q96FF9* / cell division cycle associated 5*  / reaction
 ENSMUSG00000006398 Cdc20 / Q9JJ66 / Cell division cycle / Q12834* / cell division cycle 20*  / reaction
 ENSMUSG00000032254 Kif23 / E9Q5G3 / Kinesin-like protein KIF23 / Q02241* / kinesin family member 23*  / reaction
 ENSMUSG00000031016 Wee1 / P47810 / WEE 1 homolog 1 (S. pombe) / P30291* / WEE1 G2 checkpoint kinase*  / reaction
 ENSMUSG00000041408 Wapl / Q65Z40 / WAPL cohesin release factor / Q7Z5K2*  / reaction
 ENSMUSG00000073557 Q8BG95 / Ppp1r12b / protein phosphatase 1, regulatory (inhibitor) subunit 12B / O60237* / protein phosphatase 1 regulatory subunit 12B*  / reaction
 ENSMUSG00000019907 Q9DBR7 / Ppp1r12a / protein phosphatase 1, regulatory (inhibitor) subunit 12A / O14974* / protein phosphatase 1 regulatory subunit 12A*  / reaction






 

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