ENSMUSG00000003037


Mus musculus

Features
Gene ID: ENSMUSG00000003037
  
Biological name :Rab8a
  
Synonyms : P55258 / Rab8a / RAB8A, member RAS oncogene family
  
Possible biological names infered from orthology : P61006
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 72161200
Gene end: 72183904
  
Corresponding Affymetrix probe sets: 10572757 (MoGene1.0st)   1418692_at (Mouse Genome 430 2.0 Array)   1440620_at (Mouse Genome 430 2.0 Array)   1457624_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003121
NCBI entrez gene - 17274     See in Manteia.
MGI - MGI:96960
RefSeq - NM_023126
RefSeq Peptide - NP_075615
swissprot - P55258
swissprot - Q0PD50
Ensembl - ENSMUSG00000003037
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab8aENSDARG00000067920Danio rerio
 RAB8AENSGALG00000028851Gallus gallus
 RAB8AENSG00000167461Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab8b / P61028 / RAB8B, member RAS oncogene family / Q92930*ENSMUSG0000003694385
Rab10 / P61027 / RAB10, member RAS oncogene family / P61026*ENSMUSG0000002067168
Rab13 / Q9DD03 / Ras-related protein Rab-13 / P51153* / RAB13, member RAS oncogene family*ENSMUSG0000002793563
Rab3c / P62823 / RAB3C, member RAS oncogene family / Q96E17*ENSMUSG0000002170050
Rab3a / P63011 / RAB3A, member RAS oncogene family / P20336*ENSMUSG0000003184049
Rab3d / P35276 / RAB3D, member RAS oncogene family / O95716*ENSMUSG0000001906649
Rab3b / Q9CZT8 / RAB3B, member RAS oncogene family / P20337*ENSMUSG0000000341148
Rab15 / RAB15, member RAS oncogene family / P59190*ENSMUSG0000002106247
Rab12 / P35283 / Ras-related protein Rab-12 / Q6IQ22* / RAB12, member RAS oncogene family*ENSMUSG0000002346044
Q9ERI2 / Rab27a / RAB27A, member RAS oncogene family / P51159*ENSMUSG0000003220243
Q99P58 / Rab27b / RAB27B, member RAS oncogene family / O00194*ENSMUSG0000002451141
Rasef / Q5RI75 / Ras and EF-hand domain-containing protein homolog / Q8IZ41* / RAS and EF-hand domain containing*ENSMUSG0000004300336
Rab44 / Q8CB87 / Ras-related protein Rab-44 / RAB44, member RAS oncogene family*ENSMUSG0000006414733


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006904 vesicle docking involved in exocytosis IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0009306 protein secretion IBA
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0017157 regulation of exocytosis IBA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0048210 Golgi vesicle fusion to target membrane IEA
 biological_processGO:0051223 regulation of protein transport IEA
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0098969 neurotransmitter receptor transport to postsynaptic membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium ISO
 cellular_componentGO:0008021 synaptic vesicle IBA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030140 trans-Golgi network transport vesicle IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0030667 secretory granule membrane IBA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0055037 recycling endosome IDA
 cellular_componentGO:0055038 recycling endosome membrane ISS
 cellular_componentGO:0097546 ciliary base IDA
 cellular_componentGO:0097730 non-motile cilium IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0017137 Rab GTPase binding ISS
 molecular_functionGO:0019003 GDP binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031489 myosin V binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Anchoring of the basal body to the plasma membrane
VxPx cargo-targeting to cilium
TBC/RABGAPs
RAB geranylgeranylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdc42tm1Brak/Cdc42+,Rab8atm1.1Aha/Rab8a+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Rab8atm1Aha/Rab8atm1Aha
Genetic Background: Not Specified

 MP:0001666 abnormal nutrient absorption "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Rab8atm1Aha/Rab8atm1Aha
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Rab8atm1.1Aha/Rab8atm1.2Aha,Tg(Vil1-cre)997Gum/?
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Rab8atm1Aha/Rab8atm1Aha
Genetic Background: Not Specified

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

 MP:0003288 intestinal edema "an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cdc42tm1Brak/Cdc42+,Rab8atm1.1Aha/Rab8a+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0003925 abnormal cellular glucose import "anomaly in the ability of a cell to take in glucose from the environment" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cdc42tm1Brak/Cdc42+,Rab8atm1.1Aha/Rab8a+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0004843 abnormal Paneth cell morphology "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc42tm1Brak/Cdc42+,Rab8atm1.1Aha/Rab8a+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Rab8atm1Aha/Rab8atm1Aha
Genetic Background: Not Specified

 MP:0005060 accumulation of giant lysosomes in kidney/renal tubule cells "buildup of contents in lysosomes in cells of the kidney tubules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5590]
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Rab8atm1Aha/Rab8atm1Aha
Genetic Background: Not Specified

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Rab8atm1Aha/Rab8atm1Aha
Genetic Background: Not Specified

 MP:0008109 abnormal small intestinal microvillus morphology "any structural anomaly of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

 MP:0008141 decreased small intestinal microvillus size "reduced size of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Rab8atm1Aha/Rab8atm1Aha
Genetic Background: Not Specified

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc42tm1Brak/Cdc42+,Rab8atm1.1Aha/Rab8a+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022377 Asap1 / Q9QWY8 / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 / Q9ULH1* / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1*  / complex
 ENSMUSG00000005864 Cnga2 / Q62398 / Cyclic nucleotide-gated olfactory channel / Q16280* / cyclic nucleotide gated channel alpha 2*  / complex
 ENSMUSG00000030897 Cnga4 / Q3UW12 / Cyclic nucleotide-gated cation channel alpha-4 / Q8IV77* / cyclic nucleotide gated channel alpha 4*  / complex
 ENSMUSG00000030324 Rho / P15409 / Rhodopsin / P08100*  / complex
 ENSMUSG00000037098 Q8CHD8 / Rab11fip3 / Rab11 family-interacting protein 3 / O75154*  / complex
 ENSMUSG00000004771 P62492 / Rab11a / RAB11A, member RAS oncogene family / P62491*  / complex / reaction
 ENSMUSG00000032855 Pkd1 / O08852 / Polycystin-1 / P98161* / polycystin 1, transient receptor potential channel interacting*  / complex
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / complex
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / complex
 ENSMUSG00000026672 Optn / Q8K3K8 / Mus musculus optineurin (Optn), transcript variant 1, mRNA. / Q96CV9* / optineurin*  / complex
 ENSMUSG00000030867 Plk1 / Q07832 / polo like kinase 1 / P53350*  / reaction
 ENSMUSG00000027378 Nphp1 / nephronophthisis 1 (juvenile) homolog (human) / O15259* / nephrocystin 1*  / reaction
 ENSMUSG00000039577 Nphp4 / P59240 / Mus musculus nephronophthisis 4 (juvenile) homolog (human) (Nphp4), transcript variant 2, mRNA. / O75161* / nephrocystin 4*  / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / complex
 ENSMUSG00000038520 Q8BYH7 / Tbc1d17 / TBC1 domain family, member 17 / Q9HA65*  / complex / reaction
 ENSMUSG00000033282 Q8CG73 / Rpgrip1l / Rpgrip1-like / Q68CZ1*  / reaction
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / complex






 

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