ENSMUSG00000032202


Mus musculus

Features
Gene ID: ENSMUSG00000032202
  
Biological name :Rab27a
  
Synonyms : Q9ERI2 / Rab27a / RAB27A, member RAS oncogene family
  
Possible biological names infered from orthology : P51159
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: D
Gene start: 73044854
Gene end: 73097629
  
Corresponding Affymetrix probe sets: 10587023 (MoGene1.0st)   1425284_a_at (Mouse Genome 430 2.0 Array)   1425285_a_at (Mouse Genome 430 2.0 Array)   1429123_at (Mouse Genome 430 2.0 Array)   1454438_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034722
Ensembl peptide - ENSMUSP00000139310
NCBI entrez gene - 11891     See in Manteia.
MGI - MGI:1861441
RefSeq - XM_006510780
RefSeq - NM_001301230
RefSeq - NM_001301232
RefSeq - NM_023635
RefSeq Peptide - NP_001288161
RefSeq Peptide - NP_076124
RefSeq Peptide - NP_001288159
swissprot - Q544U7
swissprot - Q9ERI2
Ensembl - ENSMUSG00000032202
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab27aENSDARG00000103935Danio rerio
 RAB27AENSGALG00000004435Gallus gallus
 P51159ENSG00000069974Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99P58 / Rab27b / RAB27B, member RAS oncogene family / O00194*ENSMUSG0000002451171
Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*ENSMUSG0000000303740
Rab3c / P62823 / RAB3C, member RAS oncogene family / Q96E17*ENSMUSG0000002170040
Rab3b / Q9CZT8 / RAB3B, member RAS oncogene family / P20337*ENSMUSG0000000341139
Rab3a / P63011 / RAB3A, member RAS oncogene family / P20336*ENSMUSG0000003184039
Rab3d / P35276 / RAB3D, member RAS oncogene family / O95716*ENSMUSG0000001906639
Rab8b / P61028 / RAB8B, member RAS oncogene family / Q92930*ENSMUSG0000003694338
Rab10 / P61027 / RAB10, member RAS oncogene family / P61026*ENSMUSG0000002067137
Rab44 / Q8CB87 / Ras-related protein Rab-44 / RAB44, member RAS oncogene family*ENSMUSG0000006414736
Rab13 / Q9DD03 / Ras-related protein Rab-13 / P51153* / RAB13, member RAS oncogene family*ENSMUSG0000002793536
Rasef / Q5RI75 / Ras and EF-hand domain-containing protein homolog / Q8IZ41* / RAS and EF-hand domain containing*ENSMUSG0000004300335
Rab15 / RAB15, member RAS oncogene family / P59190*ENSMUSG0000002106232
Rab12 / P35283 / Ras-related protein Rab-12 / Q6IQ22* / RAB12, member RAS oncogene family*ENSMUSG0000002346030


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IMP
 biological_processGO:0006887 exocytosis ISO
 biological_processGO:0007596 blood coagulation IMP
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0016192 vesicle-mediated transport IMP
 biological_processGO:0019882 antigen processing and presentation ISO
 biological_processGO:0030318 melanocyte differentiation IMP
 biological_processGO:0032400 melanosome localization ISO
 biological_processGO:0032402 melanosome transport IMP
 biological_processGO:0036257 multivesicular body organization ISO
 biological_processGO:0043316 cytotoxic T cell degranulation IMP
 biological_processGO:0043320 natural killer cell degranulation IMP
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0045921 positive regulation of exocytosis IBA
 biological_processGO:0050766 positive regulation of phagocytosis ISO
 biological_processGO:0051875 pigment granule localization IMP
 biological_processGO:0051904 pigment granule transport IMP
 biological_processGO:0071985 multivesicular body sorting pathway ISO
 biological_processGO:0097278 complement-dependent cytotoxicity ISO
 biological_processGO:1903307 positive regulation of regulated secretory pathway ISO
 biological_processGO:1903428 positive regulation of reactive oxygen species biosynthetic process ISO
 biological_processGO:1903435 positive regulation of constitutive secretory pathway ISO
 biological_processGO:1990182 exosomal secretion ISO
 cellular_componentGO:0001750 photoreceptor outer segment IDA
 cellular_componentGO:0005622 intracellular ISS
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030141 secretory granule IMP
 cellular_componentGO:0030425 dendrite ISO
 cellular_componentGO:0030667 secretory granule membrane IEA
 cellular_componentGO:0032585 multivesicular body membrane ISO
 cellular_componentGO:0033093 Weibel-Palade body IEA
 cellular_componentGO:0042470 melanosome ISO
 cellular_componentGO:0070382 exocytic vesicle ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0019003 GDP binding ISO
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031489 myosin V binding IPI


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: B6.FVB-1700016L21RikTg(Itgax-DTR/EGFP)57Lan

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: B6.FVB-1700016L21RikTg(Itgax-DTR/EGFP)57Lan

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Rab27aash-N/Rab27aash-N
Genetic Background: B10.F

Allelic Composition: Mregdsu/Mregdsu,Rab27aash/Rab27aash
Genetic Background: involves: C3H/HeSn

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1Tiz/Rab27btm1Tiz
Genetic Background: involves: 129P2/OlaHsd * C3H/He * C3H/HeSn

Allelic Composition: Rab27am2Btlr/Rab27am2Btlr
Genetic Background: C57BL/6J-Rab27am2Btlr

Allelic Composition: Rab27am3Btlr/Rab27am3Btlr
Genetic Background: C57BL/6J-Rab27am3Btlr

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: B6.FVB-1700016L21RikTg(Itgax-DTR/EGFP)57Lan

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: B6.FVB-1700016L21RikTg(Itgax-DTR/EGFP)57Lan

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Blnw/Gli2tm1Blnw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Rab27aash-N/Rab27aash-N
Genetic Background: B10.F

Allelic Composition: Rab27am1Anu/Rab27am1Anu
Genetic Background: C57BL/6JAnu-Rab27am1Anu

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: B6.FVB-1700016L21RikTg(Itgax-DTR/EGFP)57Lan

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL * C57BL/10 * C57BR

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: B4gat1tm1Mifu/B4gat1tm1Mifu,Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rab27aash/Rab27aash
Genetic Background: B6.C3Sn-Rab27aash

 MP:0002877 abnormal melanocyte morphology "malformation of the cells that produce pigment " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Rab27aash/Rab27aash
Genetic Background: B6.C3Sn-Rab27aash

 MP:0003798 abnormal Harderian gland pigmentation "anomalous coloring of the sebaceous gland located behind the eyeball in the orbit that excretes fluid that facilitates movement of the third eyelid" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

 MP:0004721 abnormal platelet dense granule morphology "any structural anomaly of the electron-dense bodies occurring in blood platelets that store and secrete adenosine nucleotides and serotonin" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/J

 MP:0004725 decreased platelet serotonin level "reduced concentration of serotonin in the platelets; this biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1.2Seab/Rab27btm1.2Seab
Genetic Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: a/a,Rab27aash/Rab27aash
Genetic Background: involves: C3H/HeSnJ * C57BL/6J

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: B6.FVB-1700016L21RikTg(Itgax-DTR/EGFP)57Lan

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: B6.C3Sn-Rab27aash

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Rab27aash/Rab27aash
Genetic Background: B6.C3Sn-Rab27aash

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rab27aash/Rab27aash
Genetic Background: B6.C3Sn-Rab27aash

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Rab27aash/Rab27aash
Genetic Background: B6.C3Sn-Rab27aash

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL * C57BL/10 * C57BR

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rab27aash/Rab27aash
Genetic Background: B6.C3Sn-Rab27aash

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/J

Allelic Composition: a/a,Rab27aash/Rab27aash
Genetic Background: involves: C3H/HeSnJ * C57BL/6J

 MP:0008327 abnormal corticotroph morphology "any structural anomaly of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)" [CL:0000467, MESH:A06.407.747.608.500]
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Allelic Composition: Rab27aash/Rab27aash,Rab27btm1Tiz/Rab27btm1Tiz
Genetic Background: involves: 129P2/OlaHsd * C3H/He * C3H/HeSn

 MP:0008546 abnormal vesicle-mediated transport "anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell" [GO:0016192]
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Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Rab27aash/Rab27aash
Genetic Background: B6.C3Sn-Rab27aash

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Rab27aash/Rab27aash
Genetic Background: B6.C3Sn-Rab27aash

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Rab27aash/Rab27aash
Genetic Background: B6.C3Sn-Rab27aash

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Rab27aash/Rab27aash
Genetic Background: B6.C3Sn-Rab27aash

 MP:0008790 abnormal NK cell degranulation "anomalies in the exocytosis of secretory granules containing preformed mediators, such as perforin and granzyme, from NK cells" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

 MP:0008791 decreased NK cell degranulation "reduction in the exocytosis of secretory granules containing preformed mediators, such as perforin and granzyme, from NK cells" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rab27aash/Rab27aash
Genetic Background: B6.C3Sn-Rab27aash

 MP:0008834 abnormal melanosome transport "any anomaly in the directed movement of melanosomes into, out of, within or between cells" [GO:0032402]
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Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

 MP:0009446 abnormal platelet dense granule physiology "any functional anomaly of the specialized secretory organelles located in the small, irregularly shaped anuclear cells derived from fragmentation of precursor megakaryocytes that contain adenine nucleotides (ADP and ATP), ionized calcium, histamine, serotonin, and epinephrine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rab27aash/Rab27aash,Rab27btm1.2Seab/Rab27btm1.2Seab
Genetic Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/J

 MP:0009448 decreased platelet ATP level "reduced concentration of the major energy source adenosine triphosphate produced by dense bodies located in platelets" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/J

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Rab27aash/Rab27aash,Rab27btm1.2Seab/Rab27btm1.2Seab
Genetic Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/J

 MP:0009557 decreased platelet ADP level "reduced concentration of the major energy source adenosine diphosphate produced by dense bodies located in platelets" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/J

 MP:0010809 abnormal Clara cell morphology "any structural anomaly of the rounded, club-shaped, nonciliated cell protruding between ciliated cells in bronchiolar epithelium, believed to be secretory in function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rab27aash/Rab27aash,Rab27btm1.2Seab/Rab27btm1.2Seab
Genetic Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J

 MP:0010899 abnormal pulmonary alveolar system morphology 
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Allelic Composition: Rab27aash/Rab27aash,Rab27btm1.2Seab/Rab27btm1.2Seab
Genetic Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J

 MP:0010943 abnormal bronchus epithelium morphology "any structural anomaly of the epithelial layer of the bronchi" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rab27aash/Rab27aash,Rab27btm1.2Seab/Rab27btm1.2Seab
Genetic Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J

 MP:0011971 increased circulating lactate dehydrogenase level "elevated blood level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate; measurements of circulating levels are used clinically as a diagnostic indicator of tissue breakdown, some forms of cancer or particular infection types" [MeSH:D08.811.682.047.551.400, MGI:csmith]
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Allelic Composition: Rab27aash/Rab27aash
Genetic Background: B6.C3Sn-Rab27aash

 MP:0020432 decreased platelet dense granule number "decreased number of the electron-dense bodies occurring in blood platelets that store and secrete adenosine nucleotides and serotonin" [orcid.org/0000-0003-4606-0597]
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Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1.2Seab/Rab27btm1.2Seab
Genetic Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / complex
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / complex
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / complex
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / complex






 

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The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr