ENSMUSG00000023460


Mus musculus

Features
Gene ID: ENSMUSG00000023460
  
Biological name :Rab12
  
Synonyms : P35283 / Rab12 / Ras-related protein Rab-12
  
Possible biological names infered from orthology : Q6IQ22 / RAB12, member RAS oncogene family
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E1.1
Gene start: 66494512
Gene end: 66519717
  
Corresponding Affymetrix probe sets: 10452556 (MoGene1.0st)   1427992_a_at (Mouse Genome 430 2.0 Array)   1457783_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128645
Ensembl peptide - ENSMUSP00000070134
NCBI entrez gene - 19328     See in Manteia.
MGI - MGI:894284
RefSeq - NM_024448
RefSeq Peptide - NP_077768
swissprot - A2CG35
swissprot - P35283
Ensembl - ENSMUSG00000023460
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab12ENSDARG00000089428Danio rerio
 RAB12ENSGALG00000033608Gallus gallus
 RAB12ENSG00000206418Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab10 / P61027 / RAB10, member RAS oncogene family / P61026*ENSMUSG0000002067139
Rab13 / Q9DD03 / Ras-related protein Rab-13 / P51153* / RAB13, member RAS oncogene family*ENSMUSG0000002793539
Rab3a / P63011 / RAB3A, member RAS oncogene family / P20336*ENSMUSG0000003184038
Rab3c / P62823 / RAB3C, member RAS oncogene family / Q96E17*ENSMUSG0000002170038
Rab3b / Q9CZT8 / RAB3B, member RAS oncogene family / P20337*ENSMUSG0000000341138
Rab3d / P35276 / RAB3D, member RAS oncogene family / O95716*ENSMUSG0000001906637
Rab8b / P61028 / RAB8B, member RAS oncogene family / Q92930*ENSMUSG0000003694337
Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*ENSMUSG0000000303737
Rab15 / RAB15, member RAS oncogene family / P59190*ENSMUSG0000002106236
Rasef / Q5RI75 / Ras and EF-hand domain-containing protein homolog / Q8IZ41* / RAS and EF-hand domain containing*ENSMUSG0000004300333
Q99P58 / Rab27b / RAB27B, member RAS oncogene family / O00194*ENSMUSG0000002451129
Rab44 / Q8CB87 / Ras-related protein Rab-44 / RAB44, member RAS oncogene family*ENSMUSG0000006414728
Q9ERI2 / Rab27a / RAB27A, member RAS oncogene family / P51159*ENSMUSG0000003220228


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0008333 endosome to lysosome transport IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016239 positive regulation of macroautophagy IMP
 biological_processGO:0044257 cellular protein catabolic process IMP
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IEA


Pathways (from Reactome)
Pathway description
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / complex
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / complex
 ENSMUSG00000036661 A2RT67 / Dennd3 / DENN domain-containing protein 3 / A2RUS2* / DENN domain containing 3*  / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / complex
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / complex






 

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