ENSG00000206418


Homo sapiens

Features
Gene ID: ENSG00000206418
  
Biological name :RAB12
  
Synonyms : Q6IQ22 / RAB12 / RAB12, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: p11.22
Gene start: 8609445
Gene end: 8639381
  
Corresponding Affymetrix probe sets: 235059_at (Human Genome U133 Plus 2.0 Array)   236019_at (Human Genome U133 Plus 2.0 Array)   239891_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000331748
NCBI entrez gene - 201475     See in Manteia.
OMIM - 616448
RefSeq - NM_001025300
RefSeq - XM_006722300
RefSeq Peptide - NP_001020471
swissprot - Q6IQ22
Ensembl - ENSG00000206418
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab12ENSDARG00000089428Danio rerio
 RAB12ENSGALG00000033608Gallus gallus
 Rab12ENSMUSG00000023460Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB3B / P20337 / RAB3B, member RAS oncogene familyENSG0000016921339
RAB13 / P51153 / RAB13, member RAS oncogene familyENSG0000014354539
RAB3C / Q96E17 / RAB3C, member RAS oncogene familyENSG0000015293239
RAB10 / P61026 / RAB10, member RAS oncogene familyENSG0000008473339
RAB3A / P20336 / RAB3A, member RAS oncogene familyENSG0000010564938
RAB8A / P61006 / RAB8A, member RAS oncogene familyENSG0000016746138
RAB3D / O95716 / RAB3D, member RAS oncogene familyENSG0000010551436
RAB8B / Q92930 / RAB8B, member RAS oncogene familyENSG0000016612836
RAB15 / P59190 / RAB15, member RAS oncogene familyENSG0000013999836
RASEF / Q8IZ41 / RAS and EF-hand domain containingENSG0000016510535
RAB44 / RAB44, member RAS oncogene familyENSG0000025558732
O00194 / RAB27B / RAB27B, member RAS oncogene familyENSG0000004135330
P51159 / RAB27A / RAB27A, member RAS oncogene familyENSG0000006997427


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0008333 endosome to lysosome transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016239 positive regulation of macroautophagy IEA
 biological_processGO:0044257 cellular protein catabolic process IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005764 lysosome ISS
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0055038 recycling endosome membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IDA


Pathways (from Reactome)
Pathway description
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105339 A2RUS2 / DENND3 / DENN domain containing 3  / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / complex
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / complex
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / complex
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / complex






 

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