ENSG00000166128


Homo sapiens

Features
Gene ID: ENSG00000166128
  
Biological name :RAB8B
  
Synonyms : Q92930 / RAB8B / RAB8B, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q22.2
Gene start: 63189469
Gene end: 63267782
  
Corresponding Affymetrix probe sets: 219210_s_at (Human Genome U133 Plus 2.0 Array)   222846_at (Human Genome U133 Plus 2.0 Array)   226633_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453111
Ensembl peptide - ENSP00000453679
Ensembl peptide - ENSP00000453982
Ensembl peptide - ENSP00000312734
Ensembl peptide - ENSP00000453236
NCBI entrez gene - 51762     See in Manteia.
OMIM - 613532
RefSeq - XM_017022312
RefSeq - NM_016530
RefSeq Peptide - NP_057614
swissprot - H0YMN7
swissprot - H0YNE9
swissprot - H0YL94
swissprot - Q92930
swissprot - H0YLJ8
Ensembl - ENSG00000166128
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab8bENSDARG00000068628Danio rerio
 RAB8BENSGALG00000003487Gallus gallus
 Rab8bENSMUSG00000036943Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB8A / P61006 / RAB8A, member RAS oncogene familyENSG0000016746184
RAB10 / P61026 / RAB10, member RAS oncogene familyENSG0000008473367
RAB13 / P51153 / RAB13, member RAS oncogene familyENSG0000014354565
RAB15 / P59190 / RAB15, member RAS oncogene familyENSG0000013999848
RAB3A / P20336 / RAB3A, member RAS oncogene familyENSG0000010564947
RAB3C / Q96E17 / RAB3C, member RAS oncogene familyENSG0000015293246
RAB3D / O95716 / RAB3D, member RAS oncogene familyENSG0000010551446
RAB3B / P20337 / RAB3B, member RAS oncogene familyENSG0000016921345
RAB12 / Q6IQ22 / RAB12, member RAS oncogene familyENSG0000020641843
P51159 / RAB27A / RAB27A, member RAS oncogene familyENSG0000006997441
O00194 / RAB27B / RAB27B, member RAS oncogene familyENSG0000004135340
RASEF / Q8IZ41 / RAS and EF-hand domain containingENSG0000016510538
RAB44 / RAB44, member RAS oncogene familyENSG0000025558736


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006904 vesicle docking involved in exocytosis IBA
 biological_processGO:0009306 protein secretion IBA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0017157 regulation of exocytosis IBA
 biological_processGO:0019882 antigen processing and presentation IMP
 biological_processGO:0031346 positive regulation of cell projection organization IEA
 biological_processGO:0034332 adherens junction organization IEA
 biological_processGO:0045046 protein import into peroxisome membrane IDA
 biological_processGO:0051461 positive regulation of corticotropin secretion IEA
 biological_processGO:0072659 protein localization to plasma membrane IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005778 peroxisomal membrane IDA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008021 synaptic vesicle IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0030667 secretory granule membrane IBA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0051286 cell tip IEA
 cellular_componentGO:0055038 recycling endosome membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IDA
 molecular_functionGO:0030911 TPR domain binding IEA


Pathways (from Reactome)
Pathway description
TBC/RABGAPs
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123240 OPTN / Q96CV9 / optineurin  / complex
 ENSG00000104946 Q9HA65 / TBC1D17 / TBC1 domain family member 17  / complex / reaction






 

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