ENSMUSG00000036943


Mus musculus

Features
Gene ID: ENSMUSG00000036943
  
Biological name :Rab8b
  
Synonyms : P61028 / Rab8b / RAB8B, member RAS oncogene family
  
Possible biological names infered from orthology : Q92930
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: C
Gene start: 66843664
Gene end: 66919687
  
Corresponding Affymetrix probe sets: 10594645 (MoGene1.0st)   1426799_at (Mouse Genome 430 2.0 Array)   1426800_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041857
NCBI entrez gene - 235442     See in Manteia.
MGI - MGI:2442982
RefSeq - NM_173413
RefSeq Peptide - NP_775589
swissprot - P61028
swissprot - Q0PD49
Ensembl - ENSMUSG00000036943
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab8bENSDARG00000068628Danio rerio
 RAB8BENSGALG00000003487Gallus gallus
 RAB8BENSG00000166128Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*ENSMUSG0000000303785
Rab10 / P61027 / RAB10, member RAS oncogene family / P61026*ENSMUSG0000002067167
Rab13 / Q9DD03 / Ras-related protein Rab-13 / P51153* / RAB13, member RAS oncogene family*ENSMUSG0000002793564
Rab3d / P35276 / RAB3D, member RAS oncogene family / O95716*ENSMUSG0000001906647
Rab3c / P62823 / RAB3C, member RAS oncogene family / Q96E17*ENSMUSG0000002170047
Rab15 / RAB15, member RAS oncogene family / P59190*ENSMUSG0000002106247
Rab3a / P63011 / RAB3A, member RAS oncogene family / P20336*ENSMUSG0000003184047
Rab3b / Q9CZT8 / RAB3B, member RAS oncogene family / P20337*ENSMUSG0000000341146
Rab12 / P35283 / Ras-related protein Rab-12 / Q6IQ22* / RAB12, member RAS oncogene family*ENSMUSG0000002346043
Q9ERI2 / Rab27a / RAB27A, member RAS oncogene family / P51159*ENSMUSG0000003220241
Q99P58 / Rab27b / RAB27B, member RAS oncogene family / O00194*ENSMUSG0000002451141
Rasef / Q5RI75 / Ras and EF-hand domain-containing protein homolog / Q8IZ41* / RAS and EF-hand domain containing*ENSMUSG0000004300336
Rab44 / Q8CB87 / Ras-related protein Rab-44 / RAB44, member RAS oncogene family*ENSMUSG0000006414733


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006904 vesicle docking involved in exocytosis IBA
 biological_processGO:0009306 protein secretion IBA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0017157 regulation of exocytosis IBA
 biological_processGO:0019882 antigen processing and presentation IEA
 biological_processGO:0031346 positive regulation of cell projection organization IEA
 biological_processGO:0034332 adherens junction organization IEA
 biological_processGO:0045046 protein import into peroxisome membrane IEA
 biological_processGO:0051461 positive regulation of corticotropin secretion IEA
 biological_processGO:0072659 protein localization to plasma membrane IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005778 peroxisomal membrane IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008021 synaptic vesicle IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0030667 secretory granule membrane IBA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0051286 cell tip IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IEA
 molecular_functionGO:0030911 TPR domain binding IEA


Pathways (from Reactome)
Pathway description
TBC/RABGAPs
RAB geranylgeranylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbc1d10ctm1.2Psou/Tbc1d10ctm1.2Psou
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008109 abnormal small intestinal microvillus morphology "any structural anomaly of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026672 Optn / Q8K3K8 / Mus musculus optineurin (Optn), transcript variant 1, mRNA. / Q96CV9* / optineurin*  / complex
 ENSMUSG00000038520 Q8BYH7 / Tbc1d17 / TBC1 domain family, member 17 / Q9HA65*  / complex / reaction






 

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