ENSMUSG00000020671


Mus musculus

Features
Gene ID: ENSMUSG00000020671
  
Biological name :Rab10
  
Synonyms : P61027 / Rab10 / RAB10, member RAS oncogene family
  
Possible biological names infered from orthology : P61026
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A1.1
Gene start: 3247428
Gene end: 3309969
  
Corresponding Affymetrix probe sets: 10399214 (MoGene1.0st)   1422664_at (Mouse Genome 430 2.0 Array)   1429296_at (Mouse Genome 430 2.0 Array)   1453095_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021001
NCBI entrez gene - 19325     See in Manteia.
MGI - MGI:105066
RefSeq - NM_016676
RefSeq Peptide - NP_057885
swissprot - P61027
swissprot - Q4FJL0
Ensembl - ENSMUSG00000020671
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab10ENSDARG00000046106Danio rerio
 RAB10ENSGALG00000016535Gallus gallus
 RAB10ENSG00000084733Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*ENSMUSG0000000303770
Rab8b / P61028 / RAB8B, member RAS oncogene family / Q92930*ENSMUSG0000003694370
Rab13 / Q9DD03 / Ras-related protein Rab-13 / P51153* / RAB13, member RAS oncogene family*ENSMUSG0000002793562
Rab15 / RAB15, member RAS oncogene family / P59190*ENSMUSG0000002106249
Rab3d / P35276 / RAB3D, member RAS oncogene family / O95716*ENSMUSG0000001906648
Rab3b / Q9CZT8 / RAB3B, member RAS oncogene family / P20337*ENSMUSG0000000341148
Rab12 / P35283 / Ras-related protein Rab-12 / Q6IQ22* / RAB12, member RAS oncogene family*ENSMUSG0000002346047
Rab3c / P62823 / RAB3C, member RAS oncogene family / Q96E17*ENSMUSG0000002170047
Rab3a / P63011 / RAB3A, member RAS oncogene family / P20336*ENSMUSG0000003184047
Q9ERI2 / Rab27a / RAB27A, member RAS oncogene family / P51159*ENSMUSG0000003220241
Q99P58 / Rab27b / RAB27B, member RAS oncogene family / O00194*ENSMUSG0000002451140
Rab44 / Q8CB87 / Ras-related protein Rab-44 / RAB44, member RAS oncogene family*ENSMUSG0000006414734
Rasef / Q5RI75 / Ras and EF-hand domain-containing protein homolog / Q8IZ41* / RAS and EF-hand domain containing*ENSMUSG0000004300333


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport TAS
 biological_processGO:0006893 Golgi to plasma membrane transport ISS
 biological_processGO:0006904 vesicle docking involved in exocytosis IBA
 biological_processGO:0007409 axonogenesis ISS
 biological_processGO:0009306 protein secretion IBA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IMP
 biological_processGO:0016197 endosomal transport IEA
 biological_processGO:0017157 regulation of exocytosis IBA
 biological_processGO:0019882 antigen processing and presentation IEA
 biological_processGO:0030859 polarized epithelial cell differentiation ISS
 biological_processGO:0032869 cellular response to insulin stimulus IMP
 biological_processGO:0043001 Golgi to plasma membrane protein transport ISS
 biological_processGO:0045200 establishment of neuroblast polarity ISS
 biological_processGO:0071786 endoplasmic reticulum tubular network organization IEA
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0090150 establishment of protein localization to membrane IEA
 biological_processGO:0097051 establishment of protein localization to endoplasmic reticulum membrane IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1903361 protein localization to basolateral plasma membrane ISS
 cellular_componentGO:0000145 exocyst ISS
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005802 trans-Golgi network ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0005929 cilium ISO
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032593 insulin-responsive compartment IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 cellular_componentGO:0070382 exocytic vesicle IEA
 cellular_componentGO:0071782 endoplasmic reticulum tubular network IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0019003 GDP binding IEA
 molecular_functionGO:0031489 myosin V binding IEA
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / complex
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / complex
 ENSMUSG00000053641 Dennd4a / DENN domain containing 4A / Q7Z401*  / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / complex
 ENSMUSG00000038024 A6H8H2 / Dennd4c / DENN domain-containing protein 4C / Q5VZ89* / DENN domain containing 4C*  / reaction
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / complex
 ENSMUSG00000042404 Q3U1Y4 / Dennd4b / Mus musculus DENN/MADD domain containing 4B (Dennd4b), transcript variant 2, mRNA. / O75064* / DENN domain containing 4B*  / reaction






 

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