ENSG00000084733


Homo sapiens

Features
Gene ID: ENSG00000084733
  
Biological name :RAB10
  
Synonyms : P61026 / RAB10 / RAB10, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p23.3
Gene start: 26034107
Gene end: 26137454
  
Corresponding Affymetrix probe sets: 222980_at (Human Genome U133 Plus 2.0 Array)   222981_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264710
NCBI entrez gene - 10890     See in Manteia.
OMIM - 612672
RefSeq - NM_016131
RefSeq Peptide - NP_057215
swissprot - P61026
Ensembl - ENSG00000084733
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab10ENSDARG00000046106Danio rerio
 RAB10ENSGALG00000016535Gallus gallus
 Rab10ENSMUSG00000020671Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB8A / P61006 / RAB8A, member RAS oncogene familyENSG0000016746170
RAB8B / Q92930 / RAB8B, member RAS oncogene familyENSG0000016612870
RAB13 / P51153 / RAB13, member RAS oncogene familyENSG0000014354562
RAB3B / P20337 / RAB3B, member RAS oncogene familyENSG0000016921349
RAB15 / P59190 / RAB15, member RAS oncogene familyENSG0000013999849
RAB3D / O95716 / RAB3D, member RAS oncogene familyENSG0000010551448
RAB3C / Q96E17 / RAB3C, member RAS oncogene familyENSG0000015293247
RAB3A / P20336 / RAB3A, member RAS oncogene familyENSG0000010564947
RAB12 / Q6IQ22 / RAB12, member RAS oncogene familyENSG0000020641847
P51159 / RAB27A / RAB27A, member RAS oncogene familyENSG0000006997441
O00194 / RAB27B / RAB27B, member RAS oncogene familyENSG0000004135340
RASEF / Q8IZ41 / RAS and EF-hand domain containingENSG0000016510538
RAB44 / RAB44, member RAS oncogene familyENSG0000025558735


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006893 Golgi to plasma membrane transport ISS
 biological_processGO:0006904 vesicle docking involved in exocytosis IBA
 biological_processGO:0007409 axonogenesis ISS
 biological_processGO:0009306 protein secretion IBA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0016197 endosomal transport IMP
 biological_processGO:0017157 regulation of exocytosis IBA
 biological_processGO:0019882 antigen processing and presentation IMP
 biological_processGO:0030859 polarized epithelial cell differentiation ISS
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0043001 Golgi to plasma membrane protein transport ISS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045200 establishment of neuroblast polarity ISS
 biological_processGO:0071786 endoplasmic reticulum tubular network organization IMP
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0090150 establishment of protein localization to membrane IMP
 biological_processGO:0097051 establishment of protein localization to endoplasmic reticulum membrane IMP
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1903361 protein localization to basolateral plasma membrane ISS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0000145 exocyst ISS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032593 insulin-responsive compartment IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0055037 recycling endosome IDA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070382 exocytic vesicle IDA
 cellular_componentGO:0071782 endoplasmic reticulum tubular network IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IDA
 molecular_functionGO:0019003 GDP binding IDA
 molecular_functionGO:0031489 myosin V binding IPI
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion IDA


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Neutrophil degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / complex
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / complex
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / complex
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / complex
 ENSG00000137145 Q5VZ89 / DENND4C / DENN domain containing 4C  / reaction
 ENSG00000198837 O75064 / DENND4B / DENN domain containing 4B  / reaction
 ENSG00000174485 Q7Z401 / DENND4A / DENN domain containing 4A  / reaction






 

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