ENSG00000174485


Homo sapiens

Features
Gene ID: ENSG00000174485
  
Biological name :DENND4A
  
Synonyms : DENND4A / DENN domain containing 4A / Q7Z401
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q22.31
Gene start: 65658046
Gene end: 65792293
  
Corresponding Affymetrix probe sets: 1554352_s_at (Human Genome U133 Plus 2.0 Array)   214787_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000391167
Ensembl peptide - ENSP00000456605
Ensembl peptide - ENSP00000457358
Ensembl peptide - ENSP00000489304
Ensembl peptide - ENSP00000396830
NCBI entrez gene - 10260     See in Manteia.
OMIM - 600382
RefSeq - XM_017021865
RefSeq - XM_005254122
RefSeq - XM_006720371
RefSeq - XM_011521156
RefSeq - XM_011521157
RefSeq - XM_017021862
RefSeq - XM_017021863
RefSeq - XM_017021864
RefSeq - NM_001144823
RefSeq - NM_001320835
RefSeq - NM_005848
RefSeq - XM_005254120
RefSeq - XM_005254121
RefSeq Peptide - NP_005839
RefSeq Peptide - NP_001138295
RefSeq Peptide - NP_001307764
swissprot - A0A0U1RR27
swissprot - Q7Z401
swissprot - H3BTW5
swissprot - H3BSA0
Ensembl - ENSG00000174485
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dennd4aENSDARG00000062721Danio rerio
 DENND4AENSGALG00000041403Gallus gallus
 Dennd4aENSMUSG00000053641Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5VZ89 / DENND4C / DENN domain containing 4CENSG0000013714550
O75064 / DENND4B / DENN domain containing 4BENSG0000019883737
MADD / Q8WXG6 / MAP kinase activating death domainENSG0000011051415
Q6IQ26 / DENND5A / DENN domain containing 5AENSG0000018401412
Q6ZUT9 / DENND5B / DENN domain containing 5BENSG0000017045611
Q8TEH3 / DENND1A / DENN domain containing 1AENSG0000011952210
A2RUS2 / DENND3 / DENN domain containing 3ENSG0000010533910
Q8IV53 / DENND1C / DENN domain containing 1CENSG000002057449
Q6P3S1 / DENND1B / DENN domain containing 1BENSG000002130478
Q9ULE3 / DENND2A / DENN domain containing 2AENSG000001469668
ST5 / P78524 / suppression of tumorigenicity 5ENSG000001664448
Q68D51 / DENND2C / DENN domain containing 2CENSG000001759847
Q9H6A0 / DENND2D / DENN domain containing 2DENSG000001627776


Protein motifs (from Interpro)
Interpro ID Name
 IPR001194  cDENN domain
 IPR002885  Pentatricopeptide repeat
 IPR005112  dDENN domain
 IPR005113  uDENN domain
 IPR023341  MABP domain
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003677 DNA binding NAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity TAS


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / reaction
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / reaction
 ENSG00000084733 RAB10 / P61026 / RAB10, member RAS oncogene family  / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / reaction
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / reaction






 

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