ENSG00000198837


Homo sapiens

Features
Gene ID: ENSG00000198837
  
Biological name :DENND4B
  
Synonyms : DENND4B / DENN domain containing 4B / O75064
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.3
Gene start: 153929501
Gene end: 153946696
  
Corresponding Affymetrix probe sets: 202860_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435709
Ensembl peptide - ENSP00000354597
Ensembl peptide - ENSP00000357635
NCBI entrez gene - 9909     See in Manteia.
RefSeq - XM_017002993
RefSeq - XM_011510219
RefSeq - XM_011510220
RefSeq - XM_011510221
RefSeq - XM_011510222
RefSeq - NM_014856
RefSeq - XM_005245678
RefSeq - XM_005245679
RefSeq Peptide - NP_055671
swissprot - H0YEF0
swissprot - E9PAK5
swissprot - O75064
Ensembl - ENSG00000198837
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dennd4bENSDARG00000102914Danio rerio
 Q3U1Y4ENSMUSG00000042404Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7Z401 / DENND4A / DENN domain containing 4AENSG0000017448547
Q5VZ89 / DENND4C / DENN domain containing 4CENSG0000013714545
MADD / Q8WXG6 / MAP kinase activating death domainENSG0000011051417
Q6IQ26 / DENND5A / DENN domain containing 5AENSG0000018401414
Q6ZUT9 / DENND5B / DENN domain containing 5BENSG0000017045613
Q8TEH3 / DENND1A / DENN domain containing 1AENSG0000011952211
A2RUS2 / DENND3 / DENN domain containing 3ENSG0000010533911
ST5 / P78524 / suppression of tumorigenicity 5ENSG0000016644410
Q8IV53 / DENND1C / DENN domain containing 1CENSG0000020574410
Q9ULE3 / DENND2A / DENN domain containing 2AENSG0000014696610
Q6P3S1 / DENND1B / DENN domain containing 1BENSG000002130479
Q68D51 / DENND2C / DENN domain containing 2CENSG000001759849
Q9H6A0 / DENND2D / DENN domain containing 2DENSG000001627777


Protein motifs (from Interpro)
Interpro ID Name
 IPR001194  cDENN domain
 IPR002885  Pentatricopeptide repeat
 IPR005112  dDENN domain
 IPR005113  uDENN domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR023341  MABP domain
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032483 regulation of Rab protein signal transduction IDA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity TAS


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / reaction
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / reaction
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / reaction
 ENSG00000084733 RAB10 / P61026 / RAB10, member RAS oncogene family  / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / reaction






 

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