ENSG00000205744


Homo sapiens

Features
Gene ID: ENSG00000205744
  
Biological name :DENND1C
  
Synonyms : DENND1C / DENN domain containing 1C / Q8IV53
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 6467207
Gene end: 6482557
  
Corresponding Affymetrix probe sets: 221080_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467008
Ensembl peptide - ENSP00000466394
Ensembl peptide - ENSP00000466583
Ensembl peptide - ENSP00000370889
Ensembl peptide - ENSP00000437805
Ensembl peptide - ENSP00000465675
Ensembl peptide - ENSP00000466334
NCBI entrez gene - 79958     See in Manteia.
OMIM - 613634
RefSeq - XM_011528318
RefSeq - NM_001290331
RefSeq - NM_024898
RefSeq - XM_006722905
RefSeq - XM_006722906
RefSeq Peptide - NP_001277260
RefSeq Peptide - NP_079174
swissprot - K7EM30
swissprot - K7EM80
swissprot - K7EMN9
swissprot - Q8IV53
swissprot - K7ENM0
swissprot - K7EKL5
Ensembl - ENSG00000205744
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-76b14.2ENSDARG00000078503Danio rerio
 Q8CFK6ENSMUSG00000002668Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8TEH3 / DENND1A / DENN domain containing 1AENSG0000011952239
Q6P3S1 / DENND1B / DENN domain containing 1BENSG0000021304736
Q5VZ89 / DENND4C / DENN domain containing 4CENSG0000013714522
Q7Z401 / DENND4A / DENN domain containing 4AENSG0000017448521
O75064 / DENND4B / DENN domain containing 4BENSG0000019883719
Q6IQ26 / DENND5A / DENN domain containing 5AENSG0000018401415
Q6ZUT9 / DENND5B / DENN domain containing 5BENSG0000017045615
ST5 / P78524 / suppression of tumorigenicity 5ENSG0000016644414
MADD / Q8WXG6 / MAP kinase activating death domainENSG0000011051414
Q68D51 / DENND2C / DENN domain containing 2CENSG0000017598414
Q9ULE3 / DENND2A / DENN domain containing 2AENSG0000014696614
Q9H6A0 / DENND2D / DENN domain containing 2DENSG0000016277713
A2RUS2 / DENND3 / DENN domain containing 3ENSG0000010533913


Protein motifs (from Interpro)
Interpro ID Name
 IPR001194  cDENN domain
 IPR005112  dDENN domain
 IPR005113  uDENN domain
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity TAS


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / reaction
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / reaction
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / reaction
 ENSG00000111737 RAB35 / Q15286 / RAB35, member RAS oncogene family  / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / reaction






 

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