ENSG00000111737


Homo sapiens

Features
Gene ID: ENSG00000111737
  
Biological name :RAB35
  
Synonyms : Q15286 / RAB35 / RAB35, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.23
Gene start: 120095095
Gene end: 120117502
  
Corresponding Affymetrix probe sets: 205461_at (Human Genome U133 Plus 2.0 Array)   221819_at (Human Genome U133 Plus 2.0 Array)   225620_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000229340
Ensembl peptide - ENSP00000441883
Ensembl peptide - ENSP00000442555
Ensembl peptide - ENSP00000443994
NCBI entrez gene - 11021     See in Manteia.
OMIM - 604199
RefSeq - XM_017018723
RefSeq - NM_001167606
RefSeq - NM_006861
RefSeq - XM_011537779
RefSeq Peptide - NP_001161078
RefSeq Peptide - NP_006852
swissprot - F5H7F8
swissprot - Q15286
swissprot - F5H157
Ensembl - ENSG00000111737
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01072548.1ENSDARG00000102078Danio rerio
 rab35bENSDARG00000058425Danio rerio
 RAB35ENSGALG00000007308Gallus gallus
 Rab35ENSMUSG00000029518Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB1A / P62820 / RAB1A, member RAS oncogene familyENSG0000013806955
RAB1B / Q9H0U4 / RAB1B, member RAS oncogene familyENSG0000017490353
RAB30 / Q15771 / RAB30, member RAS oncogene familyENSG0000013750243
RAB26 / Q9ULW5 / RAB26, member RAS oncogene familyENSG0000016796442
Q9H082 / RAB33B / RAB33B, member RAS oncogene familyENSG0000017200742
Q14088 / RAB33A / RAB33A, member RAS oncogene familyENSG0000013459442
RAB19 / A4D1S5 / RAB19, member RAS oncogene familyENSG0000014695541
RAB43 / Q86YS6 / RAB43, member RAS oncogene familyENSG0000017278040
RAB37 / Q96AX2 / RAB37, member RAS oncogene familyENSG0000017279437
Q12829 / RAB40B / RAB40B, member RAS oncogene familyENSG0000014154235
Q96S21 / RAB40C / RAB40C, member RAS oncogene familyENSG0000019756234
Q8WXH6 / RAB40A / RAB40A, member RAS oncogene familyENSG0000017247634
P0C0E4 / RAB40AL / RAB40A likeENSG0000010212834


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IMP
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016197 endosomal transport IMP
 biological_processGO:0019882 antigen processing and presentation IMP
 biological_processGO:0031175 neuron projection development ISS
 biological_processGO:0032456 endocytic recycling IBA
 biological_processGO:0036010 protein localization to endosome IMP
 biological_processGO:0048227 plasma membrane to endosome transport IMP
 biological_processGO:1990090 cellular response to nerve growth factor stimulus ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0010008 endosome membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane TAS
 cellular_componentGO:0031253 cell projection membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0045171 intercellular bridge IDA
 cellular_componentGO:0045334 clathrin-coated endocytic vesicle IDA
 cellular_componentGO:0055038 recycling endosome membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0098993 anchored component of synaptic vesicle membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA
 molecular_functionGO:0019003 GDP binding IDA


Pathways (from Reactome)
Pathway description
TBC/RABGAPs
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / complex
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / complex
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / complex
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / complex
 ENSG00000213047 Q6P3S1 / DENND1B / DENN domain containing 1B  / reaction
 ENSG00000108953 YWHAE / P62258 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon  / reaction
 ENSG00000119522 Q8TEH3 / DENND1A / DENN domain containing 1A  / reaction
 ENSG00000205744 Q8IV53 / DENND1C / DENN domain containing 1C  / reaction






 

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