ENSMUSG00000029518


Mus musculus

Features
Gene ID: ENSMUSG00000029518
  
Biological name :Rab35
  
Synonyms : Q6PHN9 / Rab35 / RAB35, member RAS oncogene family
  
Possible biological names infered from orthology : Q15286
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 115631908
Gene end: 115647736
  
Corresponding Affymetrix probe sets: 10524781 (MoGene1.0st)   1433922_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031492
Ensembl peptide - ENSMUSP00000138402
NCBI entrez gene - 77407     See in Manteia.
MGI - MGI:1924657
RefSeq - XM_006530500
RefSeq - NM_198163
RefSeq Peptide - NP_937806
swissprot - Q3U0T9
swissprot - Q6PHN9
swissprot - S4R1W7
Ensembl - ENSMUSG00000029518
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01072548.1ENSDARG00000102078Danio rerio
 rab35bENSDARG00000058425Danio rerio
 RAB35ENSGALG00000007308Gallus gallus
 RAB35ENSG00000111737Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab1 / P62821 / Ras-related protein Rab-1A / RAB1A* / P62820* / RAB1A, member RAS oncogene family*ENSMUSG0000002014955
Rab1b / Q9D1G1 / RAB1B, member RAS oncogene family / Q9H0U4*ENSMUSG0000002487053
Rab30 / Q923S9 / RAB30, member RAS oncogene family / Q15771*ENSMUSG0000003064343
P97950 / Rab33a / RAB33A, member RAS oncogene family / Q14088*ENSMUSG0000003110442
O35963 / Rab33b / RAB33B, member RAS oncogene family / Q9H082*ENSMUSG0000002773941
Rab19 / P35294 / Ras-related protein Rab-19 / A4D1S5* / RAB19, member RAS oncogene family*ENSMUSG0000002992341
Rab26 / Q504M8 / RAB26, member RAS oncogene family / Q9ULW5*ENSMUSG0000007965741
Rab43 / Q8CG50 / RAB43, member RAS oncogene family / Q86YS6*ENSMUSG0000003005539
Rab37 / RAB37, member RAS oncogene family / Q96AX2*ENSMUSG0000002073238
Rab40b / Rab40B, member RAS oncogene family / Q12829* / RAB40A* / Q8WXH6* / P0C0E4* / RAB40AL* / RAB40A like* / RAB40A, member RAS oncogene family*ENSMUSG0000002517035
Q8VHQ4 / Rab40c / Rab40C, member RAS oncogene family / Q96S21*ENSMUSG0000002573034


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0008104 protein localization IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016197 endosomal transport IEA
 biological_processGO:0019882 antigen processing and presentation IEA
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0032456 endocytic recycling IBA
 biological_processGO:0036010 protein localization to endosome IEA
 biological_processGO:0048227 plasma membrane to endosome transport IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005905 clathrin-coated pit ISO
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0031253 cell projection membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0045171 intercellular bridge IEA
 cellular_componentGO:0045334 clathrin-coated endocytic vesicle IEA
 cellular_componentGO:0098993 anchored component of synaptic vesicle membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0019003 GDP binding IEA


Pathways (from Reactome)
Pathway description
TBC/RABGAPs
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / complex
 ENSMUSG00000002668 Q8CFK6 / Dennd1c / DENN domain-containing protein 1C / Q8IV53* / DENN domain containing 1C*  / reaction
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / complex
 ENSMUSG00000020849 Ywhae / P62259 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation prote...  / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / complex
 ENSMUSG00000056268 Q3U1T9 / Dennd1b / DENN domain-containing protein 1B / Q6P3S1* / DENN domain containing 1B*  / reaction
 ENSMUSG00000035392 Q8K382 / Dennd1a / DENN domain-containing protein 1A / Q8TEH3* / DENN domain containing 1A*  / reaction
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / complex






 

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