ENSMUSG00000035392


Mus musculus

Features
Gene ID: ENSMUSG00000035392
  
Biological name :Dennd1a
  
Synonyms : Dennd1a / DENN domain-containing protein 1A / Q8K382
  
Possible biological names infered from orthology : DENN domain containing 1A / Q8TEH3
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 37798991
Gene end: 38287390
  
Corresponding Affymetrix probe sets: 10482200 (MoGene1.0st)   1424625_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099848
Ensembl peptide - ENSMUSP00000115527
Ensembl peptide - ENSMUSP00000120998
Ensembl peptide - ENSMUSP00000119892
Ensembl peptide - ENSMUSP00000116723
Ensembl peptide - ENSMUSP00000116396
Ensembl peptide - ENSMUSP00000116018
NCBI entrez gene - 227801     See in Manteia.
MGI - MGI:2442794
RefSeq - XM_017317481
RefSeq - XM_006498000
RefSeq - XM_006498001
RefSeq - XM_006498002
RefSeq - XM_006498003
RefSeq - XM_006498004
RefSeq - XM_006498005
RefSeq - XM_006498007
RefSeq - XM_011239087
RefSeq - NM_146122
RefSeq - XM_006497998
RefSeq - XM_006497999
RefSeq Peptide - NP_666234
swissprot - D6RHL0
swissprot - D6RH88
swissprot - A2AUP6
swissprot - A2ALU3
swissprot - D6RI65
swissprot - D6RHP6
swissprot - Q8K382
Ensembl - ENSMUSG00000035392
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dennd1aENSDARG00000014592Danio rerio
 DENND1AENSGALG00000001157Gallus gallus
 Q8TEH3ENSG00000119522Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3U1T9 / Dennd1b / DENN domain-containing protein 1B / Q6P3S1* / DENN domain containing 1B*ENSMUSG0000005626837
Q8CFK6 / Dennd1c / DENN domain-containing protein 1C / Q8IV53* / DENN domain containing 1C*ENSMUSG0000000266829
A6H8H2 / Dennd4c / DENN domain-containing protein 4C / Q5VZ89* / DENN domain containing 4C*ENSMUSG0000003802419
Dennd4a / DENN domain containing 4A / Q7Z401*ENSMUSG0000005364119
Q3U1Y4 / Dennd4b / Mus musculus DENN/MADD domain containing 4B (Dennd4b), transcript variant 2, mRNA. / O75064* / DENN domain containing 4B*ENSMUSG0000004240417
A2RT67 / Dennd3 / DENN domain-containing protein 3 / A2RUS2* / DENN domain containing 3*ENSMUSG0000003666114
A2RSQ0 / Dennd5b / DENN domain-containing protein 5B / Q6ZUT9* / DENN domain containing 5B*ENSMUSG0000003031313
Q6PAL8 / Dennd5a / DENN domain-containing protein 5A / Q6IQ26* / DENN domain containing 5A*ENSMUSG0000003590113
Madd / MAP-kinase activating death domain / Q8WXG6*ENSMUSG0000004068713
Q8C4S8 / Dennd2a / DENN domain-containing protein 2A / Q9ULE3* / DENN domain containing 2A*ENSMUSG0000003845613
St5 / Q924W7 / Suppression of tumorigenicity 5 protein / P78524* / suppression of tumorigenicity 5*ENSMUSG0000003102412
Dennd2c / DENN domain containing 2C / Q68D51*ENSMUSG0000000737912
Q91VV4 / Dennd2d / DENN domain-containing protein 2D / Q9H6A0* / DENN domain containing 2D*ENSMUSG0000002790110


Protein motifs (from Interpro)
Interpro ID Name
 IPR001194  cDENN domain
 IPR005112  dDENN domain
 IPR005113  uDENN domain
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0032456 endocytic recycling IDA
 biological_processGO:0032483 regulation of Rab protein signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IDA
 biological_processGO:0048488 synaptic vesicle endocytosis IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017124 SH3 domain binding IPI
 molecular_functionGO:0017137 Rab GTPase binding IPI
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding IDA
 molecular_functionGO:1901981 phosphatidylinositol phosphate binding IDA


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000020849 Ywhae / P62259 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation prote...  / reaction / complex
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / reaction
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / reaction
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / reaction
 ENSMUSG00000029518 Rab35 / Q6PHN9 / RAB35, member RAS oncogene family / Q15286*  / reaction






 

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