ENSMUSG00000040687


Mus musculus

Features
Gene ID: ENSMUSG00000040687
  
Biological name :Madd
  
Synonyms : Madd / MAP-kinase activating death domain
  
Possible biological names infered from orthology : Q8WXG6
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E1
Gene start: 91137360
Gene end: 91183837
  
Corresponding Affymetrix probe sets: 10484941 (MoGene1.0st)   1425735_at (Mouse Genome 430 2.0 Array)   1455502_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069350
Ensembl peptide - ENSMUSP00000067210
Ensembl peptide - ENSMUSP00000074746
Ensembl peptide - ENSMUSP00000117657
Ensembl peptide - ENSMUSP00000107012
Ensembl peptide - ENSMUSP00000107007
Ensembl peptide - ENSMUSP00000107006
Ensembl peptide - ENSMUSP00000107004
Ensembl peptide - ENSMUSP00000107003
Ensembl peptide - ENSMUSP00000107002
Ensembl peptide - ENSMUSP00000107001
Ensembl peptide - ENSMUSP00000107000
Ensembl peptide - ENSMUSP00000097313
Ensembl peptide - ENSMUSP00000097311
Ensembl peptide - ENSMUSP00000077094
NCBI entrez gene - 228355     See in Manteia.
MGI - MGI:2444672
RefSeq - XM_017317634
RefSeq - NM_001177719
RefSeq - NM_001177720
RefSeq - NM_145527
RefSeq - XM_017317619
RefSeq - XM_017317620
RefSeq - XM_017317621
RefSeq - XM_017317623
RefSeq - XM_017317624
RefSeq - XM_017317625
RefSeq - XM_017317626
RefSeq - XM_017317627
RefSeq - XM_017317628
RefSeq - XM_017317629
RefSeq - XM_017317630
RefSeq - XM_017317632
RefSeq Peptide - NP_001171190
RefSeq Peptide - NP_001171191
RefSeq Peptide - NP_663502
swissprot - A6PWP7
swissprot - A2AGR1
swissprot - A2AGR0
swissprot - A2AGQ9
swissprot - A0A0R4J1F4
swissprot - A2AGQ7
swissprot - A2AGQ6
swissprot - A2AGQ5
swissprot - A2AGQ4
swissprot - A2AGQ3
swissprot - A2AGQ2
swissprot - A2AGQ8
swissprot - E9QN47
swissprot - A6PWP8
Ensembl - ENSMUSG00000040687
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 maddENSDARG00000003495Danio rerio
 MADDENSGALG00000008181Gallus gallus
 MADDENSG00000110514Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dennd4a / DENN domain containing 4A / Q7Z401*ENSMUSG0000005364118
A6H8H2 / Dennd4c / DENN domain-containing protein 4C / Q5VZ89* / DENN domain containing 4C*ENSMUSG0000003802418
Q3U1Y4 / Dennd4b / Mus musculus DENN/MADD domain containing 4B (Dennd4b), transcript variant 2, mRNA. / O75064* / DENN domain containing 4B*ENSMUSG0000004240415
Q6PAL8 / Dennd5a / DENN domain-containing protein 5A / Q6IQ26* / DENN domain containing 5A*ENSMUSG0000003590110
A2RSQ0 / Dennd5b / DENN domain-containing protein 5B / Q6ZUT9* / DENN domain containing 5B*ENSMUSG0000003031310
Q8K382 / Dennd1a / DENN domain-containing protein 1A / Q8TEH3* / DENN domain containing 1A*ENSMUSG000000353928
A2RT67 / Dennd3 / DENN domain-containing protein 3 / A2RUS2* / DENN domain containing 3*ENSMUSG000000366618
Q3U1T9 / Dennd1b / DENN domain-containing protein 1B / Q6P3S1* / DENN domain containing 1B*ENSMUSG000000562687
St5 / Q924W7 / Suppression of tumorigenicity 5 protein / P78524* / suppression of tumorigenicity 5*ENSMUSG000000310246
Q8CFK6 / Dennd1c / DENN domain-containing protein 1C / Q8IV53* / DENN domain containing 1C*ENSMUSG000000026686
Q8C4S8 / Dennd2a / DENN domain-containing protein 2A / Q9ULE3* / DENN domain containing 2A*ENSMUSG000000384566
Dennd2c / DENN domain containing 2C / Q68D51*ENSMUSG000000073796
Q91VV4 / Dennd2d / DENN domain-containing protein 2D / Q9H6A0* / DENN domain containing 2D*ENSMUSG000000279015


Protein motifs (from Interpro)
Interpro ID Name
 IPR001194  cDENN domain
 IPR005112  dDENN domain
 IPR005113  uDENN domain
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0032483 regulation of Rab protein signal transduction IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0097194 execution phase of apoptosis IEA
 biological_processGO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:2001236 regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Aknatm2Mak/Aknatm2Mak
Genetic Background: B6.129-Aknatm2Mak

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aknatm2Mak/Aknatm2Mak
Genetic Background: B6.129-Aknatm2Mak

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0002578 impaired ability to fire action potentials "anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aknatm2Mak/Aknatm2Mak
Genetic Background: B6.129-Aknatm2Mak

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Aknatm2Mak/Aknatm2Mak
Genetic Background: B6.129-Aknatm2Mak

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aknatm2Mak/Aknatm2Mak
Genetic Background: B6.129-Aknatm2Mak

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0004769 abnormal synaptic vesicle morphology "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Maddtm1Ytk/Maddtm1Ytk
Genetic Background: involves: 129X1/SvJ

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Aknatm2Mak/Aknatm2Mak
Genetic Background: B6.129-Aknatm2Mak

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Aknatm2Mak/Aknatm2Mak
Genetic Background: B6.129-Aknatm2Mak

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Aknatm2Mak/Aknatm2Mak
Genetic Background: B6.129-Aknatm2Mak

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Aknatm2Mak/Aknatm2Mak
Genetic Background: B6.129-Aknatm2Mak

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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