ENSMUSG00000035901


Mus musculus

Features
Gene ID: ENSMUSG00000035901
  
Biological name :Dennd5a
  
Synonyms : Dennd5a / DENN domain-containing protein 5A / Q6PAL8
  
Possible biological names infered from orthology : DENN domain containing 5A / Q6IQ26
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E3
Gene start: 109893780
Gene end: 109960470
  
Corresponding Affymetrix probe sets: 10566846 (MoGene1.0st)   1424015_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079295
Ensembl peptide - ENSMUSP00000102333
NCBI entrez gene - 19347     See in Manteia.
MGI - MGI:1201681
RefSeq - NM_001311139
RefSeq - NM_021494
RefSeq Peptide - NP_001298068
RefSeq Peptide - NP_067469
swissprot - Q6PAL8
swissprot - A0A0R4J1B6
Ensembl - ENSMUSG00000035901
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dennd5aENSDARG00000017006Danio rerio
 DENND5AENSGALG00000005840Gallus gallus
 Q6IQ26ENSG00000184014Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2RSQ0 / Dennd5b / DENN domain-containing protein 5B / Q6ZUT9* / DENN domain containing 5B*ENSMUSG0000003031370
A6H8H2 / Dennd4c / DENN domain-containing protein 4C / Q5VZ89* / DENN domain containing 4C*ENSMUSG0000003802418
Q3U1Y4 / Dennd4b / Mus musculus DENN/MADD domain containing 4B (Dennd4b), transcript variant 2, mRNA. / O75064* / DENN domain containing 4B*ENSMUSG0000004240417
Dennd4a / DENN domain containing 4A / Q7Z401*ENSMUSG0000005364117
Madd / MAP-kinase activating death domain / Q8WXG6*ENSMUSG0000004068713
A2RT67 / Dennd3 / DENN domain-containing protein 3 / A2RUS2* / DENN domain containing 3*ENSMUSG0000003666112
Q8K382 / Dennd1a / DENN domain-containing protein 1A / Q8TEH3* / DENN domain containing 1A*ENSMUSG0000003539211
Q3U1T9 / Dennd1b / DENN domain-containing protein 1B / Q6P3S1* / DENN domain containing 1B*ENSMUSG0000005626810
St5 / Q924W7 / Suppression of tumorigenicity 5 protein / P78524* / suppression of tumorigenicity 5*ENSMUSG000000310249
Q8CFK6 / Dennd1c / DENN domain-containing protein 1C / Q8IV53* / DENN domain containing 1C*ENSMUSG000000026689
Q8C4S8 / Dennd2a / DENN domain-containing protein 2A / Q9ULE3* / DENN domain containing 2A*ENSMUSG000000384568
Dennd2c / DENN domain containing 2C / Q68D51*ENSMUSG000000073798
Q91VV4 / Dennd2d / DENN domain-containing protein 2D / Q9H6A0* / DENN domain containing 2D*ENSMUSG000000279017


Protein motifs (from Interpro)
Interpro ID Name
 IPR001024  PLAT/LH2 domain
 IPR001194  cDENN domain
 IPR004012  RUN domain
 IPR005112  dDENN domain
 IPR005113  uDENN domain
 IPR036392  PLAT/LH2 domain superfamily
 IPR037213  RUN domain superfamily
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0042147 retrograde transport, endosome to Golgi IEA
 biological_processGO:0050982 detection of mechanical stimulus IBA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0030904 retromer complex IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005262 calcium channel activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017137 Rab GTPase binding IDA


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / reaction
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / reaction
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / reaction
 ENSMUSG00000055069 Rab39 / Q8BHD0 / RAB39, member RAS oncogene family / Q14964* / RAB39A* / RAB39A, member RAS oncogene family*  / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / reaction






 

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