ENSMUSG00000038456


Mus musculus

Features
Gene ID: ENSMUSG00000038456
  
Biological name :Dennd2a
  
Synonyms : Dennd2a / DENN domain-containing protein 2A / Q8C4S8
  
Possible biological names infered from orthology : DENN domain containing 2A / Q9ULE3
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B1
Gene start: 39462378
Gene end: 39557867
  
Corresponding Affymetrix probe sets: 10544199 (MoGene1.0st)   1433500_at (Mouse Genome 430 2.0 Array)   1454624_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045367
Ensembl peptide - ENSMUSP00000116907
NCBI entrez gene - 209773     See in Manteia.
MGI - MGI:2444961
RefSeq - XM_017321485
RefSeq - NM_172477
RefSeq - XM_011241272
RefSeq - XM_011241273
RefSeq - XM_017321484
RefSeq - XM_006505836
RefSeq - XM_006505840
RefSeq Peptide - NP_766065
swissprot - Q8C4S8
swissprot - D3Z1C6
Ensembl - ENSMUSG00000038456
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DENND2AENSGALG00000012857Gallus gallus
 Q9ULE3ENSG00000146966Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
St5 / Q924W7 / Suppression of tumorigenicity 5 protein / P78524* / suppression of tumorigenicity 5*ENSMUSG0000003102449
Dennd2c / DENN domain containing 2C / Q68D51*ENSMUSG0000000737942
Q91VV4 / Dennd2d / DENN domain-containing protein 2D / Q9H6A0* / DENN domain containing 2D*ENSMUSG0000002790123
Q3U1Y4 / Dennd4b / Mus musculus DENN/MADD domain containing 4B (Dennd4b), transcript variant 2, mRNA. / O75064* / DENN domain containing 4B*ENSMUSG0000004240415
A6H8H2 / Dennd4c / DENN domain-containing protein 4C / Q5VZ89* / DENN domain containing 4C*ENSMUSG0000003802414
Dennd4a / DENN domain containing 4A / Q7Z401*ENSMUSG0000005364114
Q3U1T9 / Dennd1b / DENN domain-containing protein 1B / Q6P3S1* / DENN domain containing 1B*ENSMUSG0000005626813
Q8K382 / Dennd1a / DENN domain-containing protein 1A / Q8TEH3* / DENN domain containing 1A*ENSMUSG0000003539213
Q8CFK6 / Dennd1c / DENN domain-containing protein 1C / Q8IV53* / DENN domain containing 1C*ENSMUSG0000000266812
Q6PAL8 / Dennd5a / DENN domain-containing protein 5A / Q6IQ26* / DENN domain containing 5A*ENSMUSG0000003590111
A2RSQ0 / Dennd5b / DENN domain-containing protein 5B / Q6ZUT9* / DENN domain containing 5B*ENSMUSG0000003031311
Madd / MAP-kinase activating death domain / Q8WXG6*ENSMUSG0000004068711
A2RT67 / Dennd3 / DENN domain-containing protein 3 / A2RUS2* / DENN domain containing 3*ENSMUSG0000003666111


Protein motifs (from Interpro)
Interpro ID Name
 IPR001194  cDENN domain
 IPR005112  dDENN domain
 IPR005113  uDENN domain
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0042147 retrograde transport, endosome to Golgi IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000079316 Rab9 / Q9R0M6 / RAB9, member RAS oncogene family / RAB9A* / P51151* / RAB9A, member RAS oncogene family*  / reaction
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / reaction
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / reaction
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / reaction






 

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