ENSMUSG00000042404


Mus musculus

Features
Gene ID: ENSMUSG00000042404
  
Biological name :Dennd4b
  
Synonyms : Dennd4b / Mus musculus DENN/MADD domain containing 4B (Dennd4b), transcript variant 2, mRNA. / Q3U1Y4
  
Possible biological names infered from orthology : DENN domain containing 4B / O75064
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 90265185
Gene end: 90280669
  
Corresponding Affymetrix probe sets: 10493726 (MoGene1.0st)   1427014_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121350
Ensembl peptide - ENSMUSP00000096514
Ensembl peptide - ENSMUSP00000116003
Ensembl peptide - ENSMUSP00000117354
Ensembl peptide - ENSMUSP00000118483
NCBI entrez gene - 229541     See in Manteia.
MGI - MGI:2446201
RefSeq - XM_006501355
RefSeq - XM_017319543
RefSeq - XM_006501357
RefSeq - XM_006501356
RefSeq - NM_001356483
RefSeq - NM_201407
RefSeq Peptide - NP_001343412
RefSeq Peptide - NP_958809
swissprot - Q3U1Y4
swissprot - F6RPS8
swissprot - A0A0R4J172
swissprot - F6W646
swissprot - F6RXE7
Ensembl - ENSMUSG00000042404
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dennd4bENSDARG00000102914Danio rerio
 O75064ENSG00000198837Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dennd4a / DENN domain containing 4A / Q7Z401*ENSMUSG0000005364146
A6H8H2 / Dennd4c / DENN domain-containing protein 4C / Q5VZ89* / DENN domain containing 4C*ENSMUSG0000003802445
Madd / MAP-kinase activating death domain / Q8WXG6*ENSMUSG0000004068716
Q6PAL8 / Dennd5a / DENN domain-containing protein 5A / Q6IQ26* / DENN domain containing 5A*ENSMUSG0000003590114
A2RSQ0 / Dennd5b / DENN domain-containing protein 5B / Q6ZUT9* / DENN domain containing 5B*ENSMUSG0000003031313
Q8K382 / Dennd1a / DENN domain-containing protein 1A / Q8TEH3* / DENN domain containing 1A*ENSMUSG0000003539212
A2RT67 / Dennd3 / DENN domain-containing protein 3 / A2RUS2* / DENN domain containing 3*ENSMUSG0000003666111
Q8C4S8 / Dennd2a / DENN domain-containing protein 2A / Q9ULE3* / DENN domain containing 2A*ENSMUSG0000003845610
St5 / Q924W7 / Suppression of tumorigenicity 5 protein / P78524* / suppression of tumorigenicity 5*ENSMUSG0000003102410
Q3U1T9 / Dennd1b / DENN domain-containing protein 1B / Q6P3S1* / DENN domain containing 1B*ENSMUSG000000562689
Dennd2c / DENN domain containing 2C / Q68D51*ENSMUSG000000073799
Q8CFK6 / Dennd1c / DENN domain-containing protein 1C / Q8IV53* / DENN domain containing 1C*ENSMUSG000000026689
Q91VV4 / Dennd2d / DENN domain-containing protein 2D / Q9H6A0* / DENN domain containing 2D*ENSMUSG000000279017


Protein motifs (from Interpro)
Interpro ID Name
 IPR001194  cDENN domain
 IPR002885  Pentatricopeptide repeat
 IPR005112  dDENN domain
 IPR005113  uDENN domain
 IPR011989  Armadillo-like helical
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR023341  MABP domain
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032483 regulation of Rab protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / reaction
 ENSMUSG00000020671 Rab10 / P61027 / RAB10, member RAS oncogene family / P61026*  / reaction
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / reaction
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / reaction






 

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