ENSMUSG00000078185


Mus musculus

Features
Gene ID: ENSMUSG00000078185
  
Biological name :Chml
  
Synonyms : Chml / choroideremia-like
  
Possible biological names infered from orthology : CHM like, Rab escort protein 2 / P26374
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 175682237
Gene end: 175692901
  
Corresponding Affymetrix probe sets: 10360460 (MoGene1.0st)   1422322_at (Mouse Genome 430 2.0 Array)   1435926_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100600
Ensembl peptide - ENSMUSP00000148253
Ensembl peptide - ENSMUSP00000147889
Ensembl peptide - ENSMUSP00000147761
Ensembl peptide - ENSMUSP00000147362
NCBI entrez gene - 12663     See in Manteia.
MGI - MGI:101913
RefSeq - NM_021350
RefSeq Peptide - NP_067325
swissprot - A0A1B0GT93
swissprot - A0A0R4J1A1
swissprot - A0A1B0GS21
swissprot - A0A1B0GR39
Ensembl - ENSMUSG00000078185
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chmENSDARG00000003845Danio rerio
 CHMENSGALG00000006906Gallus gallus
 CHMLENSG00000203668Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*ENSMUSG0000002553165
Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*ENSMUSG0000001529118
Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*ENSMUSG0000002121818


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001738  Rab protein geranylgeranyltransferase component A
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR018203  GDP dissociation inhibitor
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0018344 protein geranylgeranylation IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005968 Rab-protein geranylgeranyltransferase complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005092 GDP-dissociation inhibitor activity IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA


Pathways (from Reactome)
Pathway description
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019832 Rab32 / Q9CZE3 / RAB32, member RAS oncogene family / Q13637*  / complex
 ENSMUSG00000002668 Q8CFK6 / Dennd1c / DENN domain-containing protein 1C / Q8IV53* / DENN domain containing 1C*  / reaction
 ENSMUSG00000026867 Gapvd1 / Q6PAR5 / GTPase-activating protein and VPS9 domain-containing protein 1 / Q14C86* / GTPase activating protein and VPS9 domains 1*  / reaction
 ENSMUSG00000028468 Rgp1 / Q8BHT7 / RAB6A-GEF complex partner protein 2 / Q92546* / RGP1 homolog, RAB6A GEF complex partner 1*  / reaction
 ENSMUSG00000036104 Q80UJ7 / Rab3gap1 / Rab3 GTPase-activating protein catalytic subunit / Q15042* / RAB3 GTPase activating protein catalytic subunit 1*  / reaction
 ENSMUSG00000038456 Q8C4S8 / Dennd2a / DENN domain-containing protein 2A / Q9ULE3* / DENN domain containing 2A*  / reaction
 ENSMUSG00000036661 A2RT67 / Dennd3 / DENN domain-containing protein 3 / A2RUS2* / DENN domain containing 3*  / reaction
 ENSMUSG00000042328 Hps4 / Q99KG7 / Hermansky-Pudlak syndrome 4 protein homolog / Q9NQG7* / HPS4, biogenesis of lysosomal organelles complex 3 subunit 2*  / reaction
 ENSMUSG00000053641 Dennd4a / DENN domain containing 4A / Q7Z401*  / reaction
 ENSMUSG00000034867 Q3UMR0 / Ankrd27 / Ankyrin repeat domain-containing protein 27 / Q96NW4* / ankyrin repeat domain 27*  / reaction
 ENSMUSG00000029617 Ccz1 / Q8C1Y8 / Vacuolar fusion / CCZ1B* / P86790* / P86791* / CCZ1 homolog, vacuolar protein trafficking and biogenesis associated* / CCZ1 homolog B, vacuolar protein trafficking and bio...  / reaction
 ENSMUSG00000032583 Mon1a / MON1 homolog A, secretory trafficking associated / Q86VX9*  / reaction
 ENSMUSG00000040818 Q8BH65 / Dennd6a / Protein DENND6A / Q8IWF6* / DENN domain containing 6A*  / reaction
 ENSMUSG00000038658 Ric1 / Q69ZJ7 / RAB6A-GEF complex partner protein 1 / Q4ADV7* / RIC1 homolog, RAB6A GEF complex partner 1*  / reaction
 ENSMUSG00000079316 Rab9 / Q9R0M6 / RAB9, member RAS oncogene family / RAB9A* / P51151* / RAB9A, member RAS oncogene family*  / complex
 ENSMUSG00000020849 Ywhae / P62259 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation prote...  / reaction
 ENSMUSG00000044456 Rin3 / P59729 / Ras and Rab interactor 3 / Q8TB24*  / reaction
 ENSMUSG00000038024 A6H8H2 / Dennd4c / DENN domain-containing protein 4C / Q5VZ89* / DENN domain containing 4C*  / reaction
 ENSMUSG00000039318 Rab3gap2 / RAB3 GTPase activating non-catalytic protein subunit 2 / Q9H2M9*  / reaction
 ENSMUSG00000055069 Rab39 / Q8BHD0 / RAB39, member RAS oncogene family / Q14964* / RAB39A* / RAB39A, member RAS oncogene family*  / complex
 ENSMUSG00000035901 Q6PAL8 / Dennd5a / DENN domain-containing protein 5A / Q6IQ26* / DENN domain containing 5A*  / reaction
 ENSMUSG00000015377 Q9D9V7 / Dennd6b / Protein DENND6B / Q8NEG7* / DENN domain containing 6B*  / reaction
 ENSMUSG00000056268 Q3U1T9 / Dennd1b / DENN domain-containing protein 1B / Q6P3S1* / DENN domain containing 1B*  / reaction
 ENSMUSG00000035392 Q8K382 / Dennd1a / DENN domain-containing protein 1A / Q8TEH3* / DENN domain containing 1A*  / reaction
 ENSMUSG00000030559 Rab38 / Q8QZZ8 / RAB38, member RAS oncogene family / P57729*  / complex
 ENSMUSG00000056515 Rab31 / RAB31, member RAS oncogene family / Q13636*  / complex
 ENSMUSG00000032202 Q9ERI2 / Rab27a / RAB27A, member RAS oncogene family / P51159*  / complex
 ENSMUSG00000003037 Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*  / complex
 ENSMUSG00000038975 P53612 / Rabggtb / Rab geranylgeranyl transferase, b subunit / P53611* / Rab geranylgeranyltransferase beta subunit*  / reaction / complex
 ENSMUSG00000073639 Rab18 / P35293 / RAB18, member RAS oncogene family / Q9NP72*  / complex
 ENSMUSG00000020671 Rab10 / P61027 / RAB10, member RAS oncogene family / P61026*  / complex
 ENSMUSG00000017831 Rab5a / Q9CQD1 / Ras-related protein Rab-5A / P20339* / RAB5A, member RAS oncogene family*  / complex
 ENSMUSG00000023460 Rab12 / P35283 / Ras-related protein Rab-12 / Q6IQ22* / RAB12, member RAS oncogene family*  / complex
 ENSMUSG00000031840 Rab3a / P63011 / RAB3A, member RAS oncogene family / P20336*  / complex
 ENSMUSG00000026878 Rab14 / Q91V41 / RAB14, member RAS oncogene family / P61106*  / complex
 ENSMUSG00000040472 Q9JHK4 / Rabggta / Geranylgeranyl transferase type-2 subunit alpha / Q92696* / Rab geranylgeranyltransferase alpha subunit*  / complex / reaction
 ENSMUSG00000079477 Rab7 / P51150 / RAB7, member RAS oncogene family / RAB7A* / P51149* / RAB7A, member RAS oncogene family*  / complex
 ENSMUSG00000020132 Rab21 / P35282 / RAB21, member RAS oncogene family / Q9UL25*  / complex
 ENSMUSG00000029518 Rab35 / Q6PHN9 / RAB35, member RAS oncogene family / Q15286*  / complex
 ENSMUSG00000027935 Rab13 / Q9DD03 / Ras-related protein Rab-13 / P51153* / RAB13, member RAS oncogene family*  / complex
 ENSMUSG00000020149 Rab1 / P62821 / Ras-related protein Rab-1A / RAB1A* / P62820* / RAB1A, member RAS oncogene family*  / complex
 ENSMUSG00000030704 Rab6a / P35279 / RAB6A, member RAS oncogene family / RAB6C* / RAB6D* / Q9H0N0* / P20340* / RAB6C, member RAS oncogene family* / RAB6D, member RAS oncogene family*  / complex
 ENSMUSG00000042404 Q3U1Y4 / Dennd4b / Mus musculus DENN/MADD domain containing 4B (Dennd4b), transcript variant 2, mRNA. / O75064* / DENN domain containing 4B*  / reaction
 ENSMUSG00000024663 Q8VDV3 / Rab3il1 / Mus musculus RAB3A interacting protein (rabin3)-like 1 (Rab3il1), transcript variant 2, mRNA. / Q8TBN0* / RAB3A interacting protein like 1*  / reaction
 ENSMUSG00000030313 A2RSQ0 / Dennd5b / DENN domain-containing protein 5B / Q6ZUT9* / DENN domain containing 5B*  / reaction
 ENSMUSG00000036529 Sbf1 / Q6ZPE2 / SET binding factor 1 / O95248*  / reaction






 

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